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The surge in availability of genomic data holds promise for enabling determination of genetic causes of observed individual traits, with applications to problems such as discovery of the genetic roots of phenotypes, be they molecular…

分布式、并行与集群计算 · 计算机科学 2018-04-23 Wayne Joubert , James Nance , Deborah Weighill , Daniel Jacobson

Discovering causal relationships from observational data is a crucial problem and it has applications in many research areas. The PC algorithm is the state-of-the-art constraint based method for causal discovery. However, runtime of the PC…

人工智能 · 计算机科学 2016-11-11 Thuc Duy Le , Tao Hoang , Jiuyong Li , Lin Liu , Huawen Liu

In this paper we solve on GPUs massive problems with large amount of data, which are not appropriate for solution with the SIMD technology. For the given problem we consider a three-level parallelization. The multithreading of CPU is used…

分布式、并行与集群计算 · 计算机科学 2014-02-18 Natalya Litvinenko

Many modern sequence alignment tools implement fast string matching using the space efficient data structure called FM-index. The succinct nature of this data structure presents unique challenges for the algorithm designers. In this paper,…

数据结构与算法 · 计算机科学 2019-09-04 Roman Snytsar

The PC algorithm is the state-of-the-art algorithm for causal structure discovery on observational data. It can be computationally expensive in the worst case due to the conditional independence tests are performed in an…

机器学习 · 计算机科学 2021-09-13 Kai Zhang , Chao Tian , Kun Zhang , Todd Johnson , Xiaoqian Jiang

Correlation Plenoptic Imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of…

Computational Pangenomics is an emerging field that studies genetic variation using a graph structure encompassing multiple genomes. Visualizing pangenome graphs is vital for understanding genome diversity. Yet, handling large graphs can be…

分布式、并行与集群计算 · 计算机科学 2026-05-29 Jiajie Li , Jan-Niklas Schmelzle , Yixiao Du , Simon Heumos , Andrea Guarracino , Giulia Guidi , Pjotr Prins , Erik Garrison , Zhiru Zhang

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

硬件体系结构 · 计算机科学 2021-11-04 Damla Senol Cali

Large-scale genomic workflows used in precision medicine can process datasets spanning tens to hundreds of gigabytes per sample, leading to high memory spikes, intensive disk I/O, and task failures due to out-of-memory errors. Simple static…

分布式、并行与集群计算 · 计算机科学 2025-11-21 Daniel Mas Montserrat , Ray Verma , Míriam Barrabés , Francisco M. de la Vega , Carlos D. Bustamante , Alexander G. Ioannidis

Correlation Clustering (CC) is a foundational problem in unsupervised learning that models binary similarity relations using labeled graphs. While classical CC has been widely studied, many real-world applications involve more nuanced…

数据结构与算法 · 计算机科学 2025-09-23 Chenglin Fan , Dahoon Lee , Euiwoong Lee

Pairwise association measure is an important operation in data analytics. Kendall's tau coefficient is one widely used correlation coefficient identifying non-linear relationships between ordinal variables. In this paper, we investigated a…

分布式、并行与集群计算 · 计算机科学 2017-04-13 Yongchao Liu , Tony Pan , Oded Green , Srinivas Aluru

As parallelism becomes critically important in the semiconductor technology, high-performance computing, and cloud applications, parallel network systems will increasingly follow suit. Today, parallelism is an essential architectural…

性能 · 计算机科学 2017-07-11 Anna Engelmann , Wolfgang Bziuk , Admela Jukan , Muriel Medard

Co-expression network is a critical technique for the identification of inter-gene interactions, which usually relies on all-pairs correlation (or similar measure) computation between gene expression profiles across multiple samples.…

分布式、并行与集群计算 · 计算机科学 2016-09-28 Yongchao Liu , Tony Pan , Srinivas Aluru

Heterogeneity in the cell population of cancer tissues poses many challenges in cancer diagnosis and treatment. Studying the heterogeneity in cell populations from gene expression measurement data in the context of cancer research is a…

分布式、并行与集群计算 · 计算机科学 2024-01-31 Anik Chaudhuri , Anwoy Mohanty , Manoranjan Satpathy

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these…

The study of approximate matching in the Massively Parallel Computations (MPC) model has recently seen a burst of breakthroughs. Despite this progress, however, we still have a far more limited understanding of maximal matching which is one…

数据结构与算法 · 计算机科学 2023-10-17 Soheil Behnezhad , MohammadTaghi Hajiaghayi , David G. Harris

Fully Connected Neural Network (FCNN) is a class of Artificial Neural Networks widely used in computer science and engineering, whereas the training process can take a long time with large datasets in existing many-core systems. Optical…

分布式、并行与集群计算 · 计算机科学 2022-11-29 Fei Dai , Yawen Chen , Haibo Zhang , Zhiyi Huang

The objective of our research is to demonstrate the practical usage and orders of magnitude speedup of real-world applications by using alternative technologies to support high performance computing. Currently, the main barrier to the…

天体物理学 · 物理学 2007-11-22 Robert J. Brunner , Volodymyr V. Kindratenko , Adam D. Myers

The problem of solving a system of polynomial equations is one of the most fundamental problems in applied mathematics. Among them, the problem of solving a system of binomial equations form a important subclass for which specialized…

代数几何 · 数学 2015-03-03 Tianran Chen , Dhagash Mehta

Molecular sequence analysis is crucial for comprehending several biological processes, including protein-protein interactions, functional annotation, and disease classification. The large number of sequences and the inherently complicated…

基因组学 · 定量生物学 2025-10-10 Sarwan Ali , Prakash Chourasia , Bipin Koirala , Murray Patterson
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