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Density-based cluster mining is known to serve a broad range of applications ranging from stock trade analysis to moving object monitoring. Although methods for efficient extraction of density-based clusters have been studied in the…

数据库 · 计算机科学 2011-11-01 Di Yang , Elke A. Rundensteiner , Matthew O. Ward

Dataset distillation (DD) promises compact yet faithful synthetic data, but existing approaches often inherit the inductive bias of a single teacher model. As dataset size increases, this bias drives generation toward overly smooth,…

Mass spectrometry (MS) based single-cell proteomics (SCP) explores cellular heterogeneity by focusing on the functional effectors of the cells - proteins. However, extracting meaningful biological information from MS data is far from…

While diffusion distillation has enabled one-step generation through methods like Variational Score Distillation, adapting distilled models to emerging new controls -- such as novel structural constraints or latest user preferences --…

计算机视觉与模式识别 · 计算机科学 2025-03-13 Yihong Luo , Tianyang Hu , Yifan Song , Jiacheng Sun , Zhenguo Li , Jing Tang

In recent years, the rapid expansion of dataset sizes and the increasing complexity of deep learning models have significantly escalated the demand for computational resources, both for data storage and model training. Dataset distillation…

计算机视觉与模式识别 · 计算机科学 2025-12-10 Zhe Li , Hadrien Reynaud , Mischa Dombrowski , Sarah Cechnicka , Franciskus Xaverius Erick , Bernhard Kainz

Significant advances have been made in the sampling efficiency of diffusion models and flow matching models, driven by Consistency Distillation (CD), which trains a student model to mimic the output of a teacher model at a later timestep.…

计算机视觉与模式识别 · 计算机科学 2024-12-10 Yunpeng Liu , Boxiao Liu , Yi Zhang , Xingzhong Hou , Guanglu Song , Yu Liu , Haihang You

Single-cell multi-omics data contain huge information of cellular states, and analyzing these data can reveal valuable insights into cellular heterogeneity, diseases, and biological processes. However, as cell differentiation \& development…

基因组学 · 定量生物学 2025-08-27 Wuchao Liu , Han Peng , Wengen Li , Yichao Zhang , Jihong Guan , Shuigeng Zhou

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

基因组学 · 定量生物学 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

Semi-supervised clustering is the task of clustering data points into clusters where only a fraction of the points are labelled. The true number of clusters in the data is often unknown and most models require this parameter as an input.…

机器学习 · 计算机科学 2013-09-27 Amar Shah , Zoubin Ghahramani

Background: Since the invention of next-generation RNA sequencing (RNA-seq) technologies, they have become a powerful tool to study the presence and quantity of RNA molecules in biological samples and have revolutionized transcriptomic…

基因组学 · 定量生物学 2021-12-01 Wei Vivian Li , Jingyi Jessica Li

Clustering has been a major research topic in the field of machine learning, one to which Deep Learning has recently been applied with significant success. However, an aspect of clustering that is not addressed by existing deep clustering…

计算机视觉与模式识别 · 计算机科学 2023-04-04 Ioannis Maniadis Metaxas , Georgios Tzimiropoulos , Ioannis Patras

Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system whose molecular mechanisms remain incompletely understood. In this study, we developed an end-to-end machine learning pipeline to analyze transcriptomic…

We consider the problem of video snapshot compressive imaging (SCI), where sequential high-speed frames are modulated by different masks and captured by a single measurement. The underlying principle of reconstructing multi-frame images…

计算机视觉与模式识别 · 计算机科学 2023-06-21 Siming Zheng , Xin Yuan

Directional data require specialized probability models because of the non-Euclidean and periodic nature of their domain. When a directional variable is observed jointly with linear variables, modeling their dependence adds an additional…

统计方法学 · 统计学 2022-12-22 Tong Zou , Hal S. Stern

Structured data offers a sophisticated mechanism for the organization of information. Existing methodologies for the text-serialization of structured data in the context of large language models fail to adequately address the heterogeneity…

计算与语言 · 计算机科学 2024-02-20 YiQiu Guo , Yuchen Yang , Ya Zhang , Yu Wang , Yanfeng Wang

Self-supervised pretraining (SSP) has been recognized as a method to enhance prediction accuracy in various downstream tasks. However, its efficacy for DNA sequences remains somewhat constrained. This limitation stems primarily from the…

机器学习 · 计算机科学 2024-05-15 Tong Yu , Lei Cheng , Ruslan Khalitov , Erland Brandser Olsson , Zhirong Yang

Advances in single-cell omics allow for unprecedented insights into the transcription profiles of individual cells. When combined with large-scale perturbation screens, through which specific biological mechanisms can be targeted, these…

机器学习 · 计算机科学 2023-10-24 Alejandro Tejada-Lapuerta , Paul Bertin , Stefan Bauer , Hananeh Aliee , Yoshua Bengio , Fabian J. Theis

While diffusion models effectively generate remarkable synthetic images, a key limitation is the inference inefficiency, requiring numerous sampling steps. To accelerate inference and maintain high-quality synthesis, teacher-student…

计算机视觉与模式识别 · 计算机科学 2024-05-27 Chi Hong , Jiyue Huang , Robert Birke , Dick Epema , Stefanie Roos , Lydia Y. Chen

Dysfluent speech modeling requires time-accurate and silence-aware transcription at both the word-level and phonetic-level. However, current research in dysfluency modeling primarily focuses on either transcription or detection, and the…

音频与语音处理 · 电气工程与系统科学 2023-12-21 Jiachen Lian , Carly Feng , Naasir Farooqi , Steve Li , Anshul Kashyap , Cheol Jun Cho , Peter Wu , Robbie Netzorg , Tingle Li , Gopala Krishna Anumanchipalli

Computational microscopy, in which hardware and algorithms of an imaging system are jointly designed, shows promise for making imaging systems that cost less, perform more robustly, and collect new types of information. Often, the…

计算机视觉与模式识别 · 计算机科学 2024-02-12 Henry Pinkard , Cherry Liu , Fanice Nyatigo , Daniel A. Fletcher , Laura Waller
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