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Calibrating mathematical models of biological processes is essential for achieving predictive accuracy and gaining mechanistic insight. However, this task remains challenging due to limited and noisy data, significant biological…

定量方法 · 定量生物学 2025-12-04 Piotr Gwiazda , Alexey Kazarnikov , Anna Marciniak-Czochra , Zuzanna Szymańska

Systems biology seeks to create math models of biological systems to reduce inherent biological complexity and provide predictions for applications such as therapeutic development. However, it remains a challenge to determine which math…

定量方法 · 定量生物学 2022-08-05 Vincent D. Zaballa , Elliot E. Hui

The scattered field formalism is combined to the particle-in-cell method to model relativistic laser-plasma dynamics in complex field configurations. Despite the strong nonlinearity of the interactions, we demonstrate the validity of this…

光学 · 物理学 2023-10-18 M. Lytova , F. Fillion-Gourdeau , S. Vallières , F. Légaré , S. MacLean

Scanning transmission electron microscopy (STEM) is an extremely versatile method for studying materials on the atomic scale. Many STEM experiments are supported or validated with electron scattering simulations. However, using the…

Reinforcement learning suffers from limitations in real practices primarily due to the number of required interactions with virtual environments. It results in a challenging problem because we are implausible to obtain a local optimal…

机器学习 · 计算机科学 2024-10-28 Qizhen Wu , Kexin Liu , Lei Chen

Machine learning (ML) has emerged as a powerful tool for tackling complex regression and classification tasks, yet its success often hinges on the quality of training data. This study introduces an ML paradigm inspired by domain knowledge…

机器学习 · 计算机科学 2025-01-10 Mohsen Rashki

The framework of reinforcement learning or optimal control provides a mathematical formalization of intelligent decision making that is powerful and broadly applicable. While the general form of the reinforcement learning problem enables…

机器学习 · 计算机科学 2018-05-22 Sergey Levine

Reinforcement learning has shown a wide usage in robotics tasks, such as insertion and grasping. However, without a practical sim2real strategy, the policy trained in simulation could fail on the real task. There are also wide researches in…

机器人学 · 计算机科学 2022-06-07 Yiwen Chen , Xue Li , Sheng Guo , Xian Yao Ng , Marcelo Ang

Rapid progress in imitation learning, foundation models, and large-scale datasets has led to robot manipulation policies that generalize to a wide-range of tasks and environments. However, rigorous evaluation of these policies remains a…

Modern distributed systems include a class of applications in which non-functional requirements are important. In particular, these applications include multimedia facilities where real time constraints are crucial to their correct…

多媒体 · 计算机科学 2007-05-23 Jeremy Bryans , Howard Bowman , John Derrick

The industrial insertion of flexible flat cables (FFCs) into receptacles presents a significant challenge owing to the need for submillimeter precision when handling the deformable cables. In manufacturing processes, FFC insertion with…

机器人学 · 计算机科学 2025-09-18 Jeongwoo Park , Seabin Lee , Changmin Park , Wonjong Lee , Changjoo Nam

A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…

定量方法 · 定量生物学 2007-05-23 Hakho Lee , Yong Liu , Donhee Ham , Robert M. Westervelt

Recently, there has been a growing interest in rescue robots due to their vital role in addressing emergency scenarios and providing crucial support in challenging or hazardous situations where human intervention is difficult. However, very…

机器人学 · 计算机科学 2025-05-19 Qianwen Zhao , Rajarshi Roy , Chad Spurlock , Kevin Lister , Long Wang

Validation is often defined as the process of determining the degree to which a model is an accurate representation of the real world from the perspective of its intended uses. Validation is crucial as industries and governments depend…

数据分析、统计与概率 · 物理学 2015-06-26 D. Sornette , A. B. Davis , K. Ide , K. R. Vixie , V. Pisarenko , J. R. Kamm

Hydrogen fuel cells are a key technology in the transition toward carbon-neutral energy systems, offering clean power with water as the only byproduct. Microfluidic fuel cells, which operate at the microliter scale, are an emerging variant…

计算工程、金融与科学 · 计算机科学 2026-03-31 Michel Takken , Robert Wille

The Finite Element Method (FEM) is a powerful modeling tool for predicting soft robots' behavior, but its computation time can limit practical applications. In this paper, a learning-based approach based on condensation of the FEM model is…

机器人学 · 计算机科学 2025-03-20 Etienne Ménager , Tanguy Navez , Paul Chaillou , Olivier Goury , Alexandre Kruszewski , Christian Duriez

Microscopy imaging plays a vital role in understanding many biological processes in development and disease. The recent advances in automation of microscopes and development of methods and markers for live cell imaging has led to rapid…

计算机视觉与模式识别 · 计算机科学 2017-05-10 Saad Ullah Akram , Juho Kannala , Lauri Eklund , Janne Heikkilä

Experiments of cell migration and chemotaxis assays have been classically performed in the so-called Boyden Chambers. A recent technology, xCELLigence Real Time Cell Analysis, is now allowing to monitor the cell migration in real time. This…

Probabilistic model checking is a widely used formal verification technique to automatically verify qualitative and quantitative properties for probabilistic models. However, capturing such systems, writing corresponding properties, and…

计算机科学中的逻辑 · 计算机科学 2024-03-04 Kangfeng Ye , Fang Yan , Simos Gerasimou

The objective of this work is to quantify the uncertainty in probability of failure estimates resulting from incomplete knowledge of the probability distributions for the input random variables. We propose a framework that couples the…

统计方法学 · 统计学 2021-10-26 Dimitris G. Giovanis , Michael Shields