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Performing causal inference in observational studies requires we assume confounding variables are correctly adjusted for. G-computation methods are often used in these scenarios, with several recent proposals using Bayesian versions of…

统计方法学 · 统计学 2021-10-25 Daniel Daly-Grafstein , Paul Gustafson

Treatment effect estimation from observational data has attracted significant attention across various research fields. However, many widely used methods rely on the unconfoundedness assumption, which is often unrealistic due to the…

机器学习 · 计算机科学 2025-02-21 Di Fan , Renlei Jiang , Yunhao Wen , Chuanhou Gao

Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and treatment-by-subgroup interactions, but inconsistencies arise…

统计方法学 · 统计学 2025-08-22 Renato Panaro , Christian Röver , Tim Friede

In interventional health studies, causal mediation analysis can be employed to investigate mechanisms through which the intervention affects the targeted health outcome. Identifying direct and indirect (i.e. mediated) effects from empirical…

In most nonrandomized observational studies, differences between treatment groups may arise not only due to the treatment but also because of the effect of confounders. Therefore, causal inference regarding the treatment effect is not as…

统计方法学 · 统计学 2018-07-04 Debashis Ghosh

Propensity score plays a central role in causal inference, but its use is not limited to causal comparisons. As a covariate balancing tool, propensity score can be used for controlled descriptive comparisons between groups whose memberships…

统计方法学 · 统计学 2022-09-09 Fan Li , Fan Li

Clinical machine learning applications are often plagued with confounders that can impact the generalizability and predictive performance of the learners. Confounding is especially problematic in remote digital health studies where the…

Machine learning practice is often impacted by confounders. Confounding can be particularly severe in remote digital health studies where the participants self-select to enter the study. While many different confounding adjustment…

应用统计 · 统计学 2019-11-14 Elias Chaibub Neto , Meghasyam Tummalacherla , Lara Mangravite , Larsson Omberg

While deep learning holds great promise for disease diagnosis and prognosis in cardiac magnetic resonance imaging, its progress is often constrained by highly imbalanced and biased training datasets. To address this issue, we propose a…

图像与视频处理 · 电气工程与系统科学 2025-09-09 Grzegorz Skorupko , Richard Osuala , Zuzanna Szafranowska , Kaisar Kushibar , Vien Ngoc Dang , Nay Aung , Steffen E Petersen , Karim Lekadir , Polyxeni Gkontra

We introduce a novel framework for decomposing interventional causal effects into synergistic, redundant, and unique components, building on the intuition of Partial Information Decomposition (PID) and the principle of M\"obius inversion.…

人工智能 · 计算机科学 2025-09-22 Abel Jansma

Causal mediation analysis has been extended to estimate path-specific effects with multiple intermediate variables, isolating treatment effects through a mediator of interest while excluding pathways through its ancestors. Such analyses…

统计方法学 · 统计学 2026-05-12 Yang Bai , Sihan Wu , Baoluo Sun , Yifan Cui

In mediation analysis, the effect of an exposure (or treatment) on an outcome variable is decomposed into two components: a direct effect, which pertains to an immediate influence of the exposure on the outcome, and an indirect effect,…

统计方法学 · 统计学 2017-10-04 Marco Geraci , Alessandra Mattei

Causal mediation analysis examines causal pathways linking exposures to disease. The estimation of interventional effects, which are mediation estimands that overcome certain identifiability problems of natural effects, has been advanced…

统计方法学 · 统计学 2025-04-23 Tong Chen , Stijn Vansteelandt , David Burgner , Toby Mansell , Margarita Moreno-Betancur

Inferring the causal effect of a treatment on an outcome in an observational study requires adjusting for observed baseline confounders to avoid bias. However, adjusting for all observed baseline covariates, when only a subset are…

统计方法学 · 统计学 2021-02-04 Wen Wei Loh , Stijn Vansteelandt

The vast majority of existing studies that estimate the average unexplained gender pay gap use unnecessarily restrictive linear versions of the Blinder-Oaxaca decomposition. Using a notably rich and large data set of 1.7 million employees…

综合经济学 · 经济学 2021-02-22 Anthony Strittmatter , Conny Wunsch

In the linear mixed model (LMM), the simultaneous assessment and comparison of dispersion relevance of explanatory variables associated with fixed and random effects remains an important open practical problem. Based on the restricted…

统计方法学 · 统计学 2023-05-31 Nicholas Schreck , Manuel Wiesenfarth

The adoption of diagnosis and prognostic algorithms in healthcare has led to concerns about the perpetuation of bias against disadvantaged groups of individuals. Deep learning methods to detect and mitigate bias have revolved around…

In causal mediation studies that decompose an average treatment effect into a natural indirect effect (NIE) and a natural direct effect (NDE), examples of post-treatment confounding are abundant. Past research has generally considered it…

统计方法学 · 统计学 2021-07-26 Guanglei Hong , Fan Yang , Xu Qin

A significant body of research in the data sciences considers unfair discrimination against social categories such as race or gender that could occur or be amplified as a result of algorithmic decisions. Simultaneously, real-world…

机器学习 · 计算机科学 2022-12-09 Lucius E. J. Bynum , Joshua R. Loftus , Julia Stoyanovich

Causal or unconfounded descriptive comparisons between multiple groups are common in observational studies. Motivated from a racial disparity study in health services research, we propose a unified propensity score weighting framework, the…

统计方法学 · 统计学 2019-07-10 Fan Li , Fan Li