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We develop a theory of aggregation using statistical mechanical methods. An example of a complicated aggregation system with several levels of structures is peptide/protein self-assembly. The problem of protein aggregation is important for…

生物大分子 · 定量生物学 2023-07-19 John S. Schreck , Jian-Min Yuan

We show that the correlated stochastic fluctuation of the friction coefficient can give rise to long-range directional motion of a particle undergoing Brownian random walk in a constant periodic energy potential landscape. The occurrence of…

软凝聚态物质 · 物理学 2009-11-07 Lorenzo Marrucci , Domenico Paparo , Markus Kreuzer

Optical tracking in vivo experiments reveal that diffusion of particles in biological cells is strongly enhanced in the presence of ATP and the experimental data for animal cells could previously be reproduced within a phenomenological…

软凝聚态物质 · 物理学 2017-03-22 Kento Yasuda , Ryuichi Okamoto , Shigeyuki Komura , Alexander S. Mikhailov

Micron-sized self-propelled (active) particles can be considered as model systems for characterizing more complex biological organisms like swimming bacteria or motile cells. We produce asymmetric microswimmers by soft lithography and study…

The movement of intracellular cargo transported by molecular motors is commonly marked by switches between directed motion and stationary pauses. The predominant measure for assessing movement is effective diffusivity, which predicts the…

定量方法 · 定量生物学 2024-12-31 Keisha J. Cook , Nathan Rayens , Linh Do , Christine K. Payne , Scott A. McKinley

We study the interplay of activity, order and flow through a set of coarse-grained equations governing the hydrodynamic velocity, concentration and stress fields in a suspension of active, energy-dissipating particles. We make several…

软凝聚态物质 · 物理学 2009-11-10 Yashodhan Hatwalne , Sriram Ramaswamy , Madan Rao , R. Aditi Simha

In order to inquire the microscopic origin of observed multiple time scales in solvation dynamics we carry out several computer experiments. We perform atomistic molecular dynamics simulations on three protein-water systems namely,…

软凝聚态物质 · 物理学 2017-10-18 Sayantan Mondal , Saumyak Mukherjee , Biman Bagchi

Adding a non-adsorbing polymer to passive colloids induces an attraction between the particles via the `depletion' mechanism. High enough polymer concentrations lead to phase separation. We combine experiments, theory and simulations to…

软凝聚态物质 · 物理学 2016-07-13 J. Schwarz-Linek , C. Valeriani , A. Cacciuto , M. E. Cates , D. Marenduzzo , A. N. Morozov , W. C. K. Poon

Behavior of the mixture of particles and dimers moving with different jump rates at reconstructed surfaces is described. Collective diffusion coefficient is calculated by the variational approach. Anisotropy of the collective particle…

统计力学 · 物理学 2014-05-12 Marcin Mińkowski , Magdalena A. Załuska Kotur

Bacterial swarming is a rapid mass-migration, in which thousands of cells spread collectively to colonize a surface. Physically, swarming is a natural example of active particles that use energy to generate motion. Accordingly,…

This short review covers a wide selection of topics from a multidisciplinary area of dynamics of nonequilibrium systems in physics, chemistry, biology. Theoretical models of colloid particle and protein deposition and adhesion at surfaces,…

凝聚态物理 · 物理学 2007-05-23 Vladimir Privman

The diffusion of active microscopic organisms in complex environments plays an important role in a wide range of biological phenomena from cell colony growth to single organism transport. Here, we investigate theoretically and…

流体动力学 · 物理学 2018-01-16 Juan L. Aragones , Shahrzad Yazdi , Alfredo Alexander-Katz

Much work has been devoted to analysing thermodynamic models for solid dispersions with a view to identifying regions in the phase diagram where amorphous phase separation or drug recrystallization can occur. However, detailed partial…

软凝聚态物质 · 物理学 2020-06-26 Martin Meere , Giuseppe Pontrelli , Sean McGinty

We propose a new method for electrophoretic separation of DNA in which adsorbed polymers are driven over a disordered two-dimensional substrate which contains attractive sites for the polymers. Using simulations of a model for long polymer…

软凝聚态物质 · 物理学 2008-03-31 C. J. Olson Reichhardt , C. Reichhardt

Phase separation plays an role in determining the self-assembly of biological and soft-matter systems. In biological systems, liquid-liquid phase separation inside a cell leads to the formation of various macromolecular aggregates. The…

软凝聚态物质 · 物理学 2024-03-26 Tanmay Biswas , Gerhard Kahl , Gaurav P. Shrivastav

Swimming bacteria create long-range velocity fields that stir a large volume of fluid and move around passive particles dispersed in the fluid. Recent experiments and simulations have shown that long-time mean-squared displacement of…

软凝聚态物质 · 物理学 2013-08-20 Alexander Morozov , Davide Marenduzzo

A simple model for simulating flows of active suspensions is investigated. The approach is based on dissipative particle dynamics. While the model is potentially applicable to a wide range of self-propelled particle systems, the specific…

流体动力学 · 物理学 2015-10-08 Denis F. Hinz , Alexander Panchenko , Tae-Yeon Kim , Eliot Fried

Microphase separation of membrane components is thought to play an important role in many physiological processes, from cell signaling to endocytosis and cellular trafficking. Here, we study how variations in the membrane composition can be…

亚细胞过程 · 定量生物学 2015-05-20 Pierre Sens , Matthew S. Turner

Bacterial chromosome replication occurs in the absence of a canonical spindle apparatus; yet it reliably produces organised and segregated genomes. While both passive and active mechanisms have been investigated, DNA replication itself is a…

生物物理 · 物理学 2026-04-02 Giada Forte , Enzo Orlandini , Davide Marenduzzo

Dielectrophoresis (DEP), the motion of polarizable particles in non-uniform electric fields, has become an important tool for the transport, separation, and characterization of microparticles in biomedical and nanoelectronics research. In…

软凝聚态物质 · 物理学 2009-11-11 E. Salonen , E. Terama , I. Vattulainen , M. Karttunen