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We report on a novel flow-based method for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. We deploy nanodiamond particles hosting fluorescent nitrogen vacancy defects as quantum sensors in…

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

定量方法 · 定量生物学 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Plastic nanoparticles present technological opportunities and environmental concerns, but measurement challenges impede product development and hazard assessment. To meet these challenges, we advance a lateral nanoflow assay that integrates…

We reveal an unreported physical mechanism that enables the pre-concentration, sorting and characterization of charged polystyrene nanobeads and liposomes dispersed in a continuous flow within a straight micron-sized channel. Initially, a…

Single-molecule motions in the nanofluidic domain are extremely difficult to characterise because of various complex physical and physicochemical interactions. We present a method for quasi-one-dimensional sub-diffraction-limited…

原子与分子团簇 · 物理学 2022-06-14 Siddharth Ghosh

High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We…

光学 · 物理学 2016-10-03 Jeewon Suh , Kewen Han , Christopher W Peterson , Gaurav Bahl

High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, we…

We present a versatile setup for investigating the nanofluidic behavior of nanoparticles as a function of the gap distance between two confining surfaces. The setup is designed as an open system which operates with small amounts of…

软凝聚态物质 · 物理学 2017-01-17 Stefan Fringes , Felix Holzner , Armin W. Knoll

Recent advance in nanotechnology has led to rapid advances in nanofluidics, which has been established as a reliable means for a wide variety of applications, including molecular separation, detection, crystallization and biosynthesis.…

定量方法 · 定量生物学 2015-03-03 Jin Kyoung Park , Kelin Xia , Guo-Wei We

The size- and fluorescence-based sorting of micro- and nano-scale particles suspended in fluid presents a significant and important challenge for both sample analysis and for manufacturing of nanoparticle-based products. Here we demonstrate…

软凝聚态物质 · 物理学 2015-02-16 Sukumar Rajauria , Christopher Axline , Claudia Gottstein , Andrew N. Cleland

Integrated micro-nanochannel networks in fluidic devices are desirable in a number of applications ranging from self-healing/cooling materials to bioengineering. The conventional micro-manufacturing techniques are capable of either…

材料科学 · 物理学 2017-04-10 Prasoon Kumar , Prasanna S Gandhi , Mainak Majumder

Biological systems have been theoretically predicted to support phononic topological wave-modes, similar to the ones existing in meta-materials. The existing methods to measure these modes, however cannot be applied to biological systems;…

生物物理 · 物理学 2023-03-03 Ssu-Ying Chen , Arooj Aslam , David J. Apigo , Sagnik Basuray , Camelia Prodan

Solid-state nanopores are emerging platforms for single-molecule protein sequencing due to their tolerance to hash physiology environment and compatibility with different electrical and optical detection methods. However, they suffer from…

应用物理 · 物理学 2024-01-05 Yingqi Zhao , Aliaksandr Hubarevich , Jian-An Huang , Francesco De Angelis

Micro/nanoporous membranes have been used extensively in biological and medical applications associated with filtration, particle sorting, cell separation, and real-time sensing. Expanding its applications to microfluidics offers several…

流体动力学 · 物理学 2025-10-28 Arijit Mohanta , Zakia Farhat , Yeshudan Bora , Saurabh Dubey , Nafisa Arfa , Dipankar Bandyopadhyay

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Nanofabrication techniques for achieving dimensional control at the nanometer scale are generally equipment-intensive and time-consuming. The use of energetic beams of electrons or ions has placed the fabrication of nanopores in thin…

介观与纳米尺度物理 · 物理学 2014-03-25 Harold Kwok , Kyle Briggs , Vincent Tabard-Cossa

Single-molecule detection at a nanometric interface in a femtomolar solution, can take weeks as the encounter rate between the diffusing molecule to be detected and the transducing nano-device is negligibly small. On the other hand, several…

Microfluidic technology provides a solution to the challenge of continuous CaCO$_3$ particle synthesis. In this study, we utilized a 3D-printed microfluidic chip to synthesize CaCO$_3$ micro and nanoparticles in vaterite form. Our primary…

Droplet-based microfluidic systems are a promising platform forlab-on-a-chip (LoC) applications. These systems can also be used toenhance LoC applications with integrated droplet control information or for data transmission scenarios in the…

新兴技术 · 计算机科学 2021-01-12 Max Bartunik , Marco Fleischer , Werner Haselmayr , Jens Kirchner

High quality metal thin films and nanostructures are critical building blocks for next generation nanotechnologies. They comprise low-loss circuit elements in nanodevices, provide new catalytic pathways for water splitting and $CO_2$…

应用物理 · 物理学 2019-06-20 Sasan V. Grayli , Xin Zhang , Finlay C. MacNab , Saeid Kamal , Gary W. Leach
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