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Drug discovery remains time-consuming, labor-intensive, and expensive, often requiring years and substantial investment per drug candidate. Predicting compound-protein interactions (CPIs) is a critical component in this process, enabling…

人工智能 · 计算机科学 2026-02-06 Zhe Wang , Zijing Liu , Chencheng Xu , Yuan Yao

Encoding and decoding models are widely used in systems, cognitive, and computational neuroscience to make sense of brain-activity data. However, the interpretation of their results requires care. Decoding models can help reveal whether…

神经元与认知 · 定量生物学 2019-04-29 Nikolaus Kriegeskorte , Pamela K. Douglas

Brains can process sensory information from different modalities at astonishing speed; this is surprising as the integration of inputs through the membrane of each individual neuron already causes a delayed response. Neuronal recordings…

神经元与认知 · 定量生物学 2024-08-20 Simon Brandt , Mihai Alexandru Petrovici , Walter Senn , Katharina Anna Wilmes , Federico Benitez

Many visual phenomena suggest that humans use top-down generative or reconstructive processes to create visual percepts (e.g., imagery, object completion, pareidolia), but little is known about the role reconstruction plays in robust object…

计算机视觉与模式识别 · 计算机科学 2023-02-09 Seoyoung Ahn , Hossein Adeli , Gregory J. Zelinsky

Variational autoencoders (VAEs) employ Bayesian inference to interpret sensory inputs, mirroring processes that occur in primate vision across both ventral (Higgins et al., 2021) and dorsal (Vafaii et al., 2023) pathways. Despite their…

机器学习 · 计算机科学 2024-12-10 Hadi Vafaii , Dekel Galor , Jacob L. Yates

Descending predictive feedback (DPF) is an ubiquitous yet unexplained phenomenon in the central nervous system. Motivated by recent observations on motor-related signals in the visual system, we approach this problem from a sensorimotor…

最优化与控制 · 数学 2021-04-01 Jing Shuang Li , Anish A. Sarma , John C. Doyle

The human brain is adept at solving difficult high-level visual processing problems such as image interpretation and object recognition in natural scenes. Over the past few years neuroscientists have made remarkable progress in…

神经元与认知 · 定量生物学 2014-07-22 Pulkit Agrawal , Dustin Stansbury , Jitendra Malik , Jack L. Gallant

Understanding what individual neurons encode is a core question in neuroscience. In primary visual cortex (V1), mathematical models (e.g., Gabor functions) capture neural selectivity, but no comparable framework exists for higher areas. We…

神经元与认知 · 定量生物学 2026-05-19 Vedang Lad , Katrin Franke , Tamar Rott Shaham , Surya Ganguli , Andreas S. Tolias , Sophia Sanborn , Nikos Karantzas

We present a new deep learning approach for matching deformable shapes by introducing {\it Shape Deformation Networks} which jointly encode 3D shapes and correspondences. This is achieved by factoring the surface representation into (i) a…

计算机视觉与模式识别 · 计算机科学 2018-07-30 Thibault Groueix , Matthew Fisher , Vladimir G. Kim , Bryan C. Russell , Mathieu Aubry

Occlusion remains a significant challenge for current vision models to robustly interpret complex and dense real-world images and scenes. To address this limitation and to enable accurate prediction of the occlusion order relationship…

计算机视觉与模式识别 · 计算机科学 2025-09-29 Kaziwa Saleh , Zhyar Rzgar K Rostam , Sándor Szénási , Zoltán Vámossy

A major goal of computational neuroscience has been to explain how the primate ventral visual stream (VVS) transforms visual input into temporally evolving neural representations that support robust visual perception. Historically, most…

神经元与认知 · 定量生物学 2026-01-21 Matteo Dunnhofer , Maren Wehrheim , Hamidreza Ramezanpour , Sabine Muzellec , Kohitij Kar

High-dimensional observations and unknown dynamics are major challenges when applying optimal control to many real-world decision making tasks. The Learning Controllable Embedding (LCE) framework addresses these challenges by embedding the…

机器学习 · 计算机科学 2020-03-03 Rui Shu , Tung Nguyen , Yinlam Chow , Tuan Pham , Khoat Than , Mohammad Ghavamzadeh , Stefano Ermon , Hung H. Bui

In this paper, we present a novel information processing architecture for safe deep learning-based visual navigation of autonomous systems. The proposed information processing architecture is used to support a perceptual attention-based…

机器人学 · 计算机科学 2019-10-17 Keuntaek Lee , Gabriel Nakajima An , Viacheslav Zakharov , Evangelos A. Theodorou

Recently, probabilistic predictive coding that directly models the conditional distribution of latent features across successive frames for temporal redundancy removal has yielded promising results. Existing methods using a single-scale…

图像与视频处理 · 电气工程与系统科学 2023-12-13 Ming Lu , Zhihao Duan , Fengqing Zhu , Zhan Ma

Current theories of perception suggest that the brain represents features of the world as probability distributions, but can such uncertain foundations provide the basis for everyday vision? Perceiving objects and scenes requires knowing…

神经元与认知 · 定量生物学 2022-11-30 Andrey Chetverikov , Árni Kristjánsson

Humans learn not only how their bodies move, but also how the surrounding world responds to their actions. In contrast, while recent Vision-Language-Action (VLA) models exhibit impressive semantic understanding, they often fail to capture…

计算机视觉与模式识别 · 计算机科学 2026-03-11 Jisoo Kim , Jungbin Cho , Sanghyeok Chu , Ananya Bal , Jinhyung Kim , Gunhee Lee , Sihaeng Lee , Seung Hwan Kim , Bohyung Han , Hyunmin Lee , Laszlo A. Jeni , Seungryong Kim

Foreground segmentation is an essential task in the field of image understanding. Under unsupervised conditions, different images and instances always have variable expressions, which make it difficult to achieve stable segmentation…

计算机视觉与模式识别 · 计算机科学 2020-05-22 Xi Li , Huimin Ma , Hongbing Ma , Yidong Wang

A common view on the brain learning processes proposes that the three classic learning paradigms -- unsupervised, reinforcement, and supervised -- take place in respectively the cortex, the basal-ganglia, and the cerebellum. However,…

神经元与认知 · 定量生物学 2021-06-08 Giovanni Granato , Emilio Cartoni , Federico Da Rold , Andrea Mattera , Gianluca Baldassarre

This paper presents results of combining (i) theoretical analysis regarding connections between the orientation selectivity and the elongation of receptive fields for the affine Gaussian derivative model with (ii) biological measurements of…

神经元与认知 · 定量生物学 2025-06-24 Tony Lindeberg

Sparse coding algorithms trained on natural images can accurately predict the features that excite visual cortical neurons, but it is not known whether such codes can be learned using biologically realistic plasticity rules. We have…

神经元与认知 · 定量生物学 2011-11-01 Joel Zylberberg , Jason Timothy Murphy , Michael Robert DeWeese
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