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Accurate computational identification of DNA methylation is essential for understanding epigenetic regulation. Although deep learning excels in this binary classification task, its "black-box" nature impedes biological insight. We address…

机器学习 · 计算机科学 2026-02-27 Yi He , Yina Cao , Jixiu Zhai , Di Wang , Junxiao Kong , Tianchi Lu

The human microbiome is the ensemble of genes in the microbes that live inside and on the surface of humans. Because microbial sequencing information is now much easier to come by than phenotypic information, there has been an explosion of…

种群与进化 · 定量生物学 2014-07-08 Frederick A Matsen

Phenotyping consists in applying algorithms to identify individuals associated with a specific, potentially complex, trait or condition, typically out of a collection of Electronic Health Records (EHRs). Because a lot of the clinical…

Quality control of assembly processes is essential in manufacturing to ensure not only the quality of individual components but also their proper integration into the final product. To assist in this matter, automated assembly control using…

计算机视觉与模式识别 · 计算机科学 2025-09-17 Jonas Werheid , Shengjie He , Aymen Gannouni , Anas Abdelrazeq , Robert H. Schmitt

Recent work has made significant progress in helping users to automate single data preparation steps, such as string-transformations and table-manipulation operators (e.g., Join, GroupBy, Pivot, etc.). We in this work propose to automate…

数据库 · 计算机科学 2021-08-05 Junwen Yang , Yeye He , Surajit Chaudhuri

The Cancer Genome Atlas (TCGA) provides researchers with clinicopathological data and genomic characterizations of various carcinomas. These data sets include expression microarrays for genes and microRNAs -- short, non-coding strands of…

定量方法 · 定量生物学 2013-07-05 Siddharth G. Reddy , Weimin Xiao , Preethi H. Gunaratne

DNA methylation (DNAme) is a critical component of the epigenetic regulatory machinery and aberrations in DNAme patterns occur in many diseases, such as cancer. Mapping and understanding DNAme profiles offers considerable promise for…

We present a new pipeline utilizing machine learning for classifying short-duration features in raw time-ordered data (TOD) of cosmic microwave background survey observations. The pipeline, specifically designed for the Atacama Cosmology…

Exponential increases in scientific experimental data are outstripping the rate of progress in silicon technology. As a result, heterogeneous combinations of architectures and process or device technologies are increasingly important to…

分布式、并行与集群计算 · 计算机科学 2024-07-02 Wilkie Olin-Ammentorp , Xingfu Wu , Andrew A. Chien

With the growing interest in deep learning algorithms and computational design in the architectural field, the need for large, accessible and diverse architectural datasets increases. We decided to tackle this problem by constructing a…

计算机视觉与模式识别 · 计算机科学 2021-07-08 Stanislava Fedorova , Alberto Tono , Meher Shashwat Nigam , Jiayao Zhang , Amirhossein Ahmadnia , Cecilia Bolognesi , Dominik L. Michels

Automated Machine Learning (AutoML) is an important industrial solution for automatic discovery and deployment of the machine learning models. However, designing an integrated AutoML system faces four great challenges of configurability,…

Neuroimaging open-data initiatives have led to increased availability of large scientific datasets. While these datasets are shifting the processing bottleneck from compute-intensive to data-intensive, current standardized analysis tools…

分布式、并行与集群计算 · 计算机科学 2024-04-18 Valérie Hayot-Sasson , Tristan Glatard

Data pipelines are an integral part of various modern data-driven systems. However, despite their importance, they are often unreliable and deliver poor-quality data. A critical step toward improving this situation is a solid understanding…

软件工程 · 计算机科学 2023-09-14 Harald Foidl , Valentina Golendukhina , Rudolf Ramler , Michael Felderer

Cancer survival prediction is an active area of research that can help prevent unnecessary therapies and improve patient's quality of life. Gene expression profiling is being widely used in cancer studies to discover informative biomarkers…

机器学习 · 计算机科学 2016-11-18 Hamid Reza Hassanzadeh , John H. Phan , May D. Wang

Camera traps have long been used by wildlife researchers to monitor and study animal behavior, population dynamics, habitat use, and species diversity in a non-invasive and efficient manner. While data collection from the field has…

计算机视觉与模式识别 · 计算机科学 2025-07-22 Bernie Boscoe , Shawn Johnson , Andrea Osbon , Chandler Campbell , Karen Mager

Currently, a variety of pipeline tools are available for use in data engineering. Data scientists can use these tools to resolve data wrangling issues associated with data and accomplish some data engineering tasks from data ingestion…

机器学习 · 计算机科学 2024-06-21 Anthony Mbata , Yaji Sripada , Mingjun Zhong

Microbiome studies have recently transitioned from experimental designs with a few hundred samples to designs spanning tens of thousands of samples. Modern studies such as the Earth Microbiome Project (EMP) afford the statistics crucial for…

基因组学 · 定量生物学 2021-11-02 Igor Sfiligoi , Daniel McDonald , Rob Knight

The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-trained models have achieved great success in analyzing these…

机器学习 · 计算机科学 2025-12-02 Zicheng Liu , Siyuan Li , Zhiyuan Chen , Chang Yu , Qirong Yang , Yucheng Guo , Yujie Yang , Xiaoming Zhang , Stan Z. Li

DNA sequence analysis is fundamental to life science research. The rapid development of next generation sequencing (NGS) technologies, and the richness and diversity of applications it makes feasible, have created an enormous gulf between…

计算工程、金融与科学 · 计算机科学 2013-10-29 Shel Swenson , Yogesh Simmhan , Viktor Prasanna , Manish Parashar , Jason Riedy , David Bader , Richard Vuduc

As scientific data repositories and filesystems grow in size and complexity, they become increasingly disorganized. The coupling of massive quantities of data with poor organization makes it challenging for scientists to locate and utilize…

信息检索 · 计算机科学 2018-10-16 Luann Jung , Brendan Whitaker , Kyle Chard , Aaron Elmore
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