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Background: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment.…

神经元与认知 · 定量生物学 2024-03-29 Sébastien Dam , Jean-Marie Batail , Gabriel H Robert , Dominique Drapier , Pierre Maurel , Julie Coloigner

Structural connectomes are detailed graphs that map how different brain regions are physically connected, offering critical insight into aging, cognition, and neurodegenerative diseases. However, these connectomes are high-dimensional and…

In this paper, we introduce the Protocol Genome, a self-supervised learning system that learns correlations from DICOM headers and achieves AUROC 0.901 (vs 0.847 baseline) and ECE 0.036 (vs 0.058) on fully held-out external validation. Our…

计算机视觉与模式识别 · 计算机科学 2025-09-10 Jimmy Joseph

The human brain is organized as a complex network, where connections between regions are characterized by both functional connectivity (FC) and structural connectivity (SC). While previous studies have primarily focused on network-level…

Multiple-subject network data are fast emerging in recent years, where a separate connectivity matrix is measured over a common set of nodes for each individual subject, along with subject covariates information. In this article, we propose…

统计方法学 · 统计学 2021-03-23 Jingfei Zhang , Will Wei Sun , Lexin Li

In neuroimaging data analysis, Gaussian graphical models are often used to model statistical dependencies across spatially remote brain regions known as functional connectivity. Typically, data is collected across a cohort of subjects and…

机器学习 · 统计学 2015-12-08 Ricardo Pio Monti , Christoforos Anagnostopoulos , Giovanni Montana

Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

神经元与认知 · 定量生物学 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

Population analyses of functional connectivity have provided a rich understanding of how brain function differs across time, individual, and cognitive task. An important but challenging task in such population analyses is the identification…

社会与信息网络 · 计算机科学 2020-08-19 James D. Wilson , Melanie Baybay , Rishi Sankar , Paul Stillman , Abbie M. Popa

Cortical folding exhibits substantial inter-individual variability while preserving stable anatomical landmarks that enable fine-scale characterization of cortical organization. Among these, the three-hinge gyrus (3HG) serves as a key…

神经元与认知 · 定量生物学 2026-02-03 Minheng Chen , Tong Chen , Yan Zhuang , Chao Cao , Jing Zhang , Tianming Liu , Lu Zhang , Dajiang Zhu

Human brain networks can be characterized at different temporal or spatial scales given by the age of the subject or the spatial resolution of the neuroimaging method. Integration of data across scales can only be successful if the combined…

Network analysis has been a powerful tool to unveil relationships and interactions among a large number of objects. Yet its effectiveness in accurately identifying important node-node interactions is challenged by the rapidly growing…

机器学习 · 统计学 2024-10-07 Tianxi Cai , Dong Xia , Luwan Zhang , Doudou Zhou

In recent years, new and important perspectives were introduced in the field of neuroimaging with the emergence of the connectionist approach. In this new context, it is important to know not only which brain areas are activated by a…

神经元与认知 · 定量生物学 2019-04-17 Jean Faber , Priscila C. Antoneli , Guillem Via , Noemi S. Araújo , Daniel J. L. L. Pinheiro , Esper Cavalheiro

Mapping the connectome of the human brain using structural or functional connectivity has become one of the most pervasive paradigms for neuroimaging analysis. Recently, Graph Neural Networks (GNNs) motivated from geometric deep learning…

神经元与认知 · 定量生物学 2022-11-30 Hejie Cui , Wei Dai , Yanqiao Zhu , Xuan Kan , Antonio Aodong Chen Gu , Joshua Lukemire , Liang Zhan , Lifang He , Ying Guo , Carl Yang

Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human…

神经元与认知 · 定量生物学 2020-06-19 Miroslav Andjelkovic , Bosiljka Tadic , Roderick Melnik

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

机器学习 · 计算机科学 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos

In the face of the stupefying complexity of the human brain, network analysis is a most useful tool that allows one to greatly simplify the problem, typically by approximating the billions of neurons comprising the brain by means of a…

神经元与认知 · 定量生物学 2023-10-03 Youssef Kora , Christoph Simon

Graph embedding is a powerful method to represent graph neurological data (e.g., brain connectomes) in a low dimensional space for brain connectivity mapping, prediction and classification. However, existing embedding algorithms have two…

计算机视觉与模式识别 · 计算机科学 2020-09-25 Alin Banka , Inis Buzi , Islem Rekik

Learning how to estimate a connectional brain template(CBT) from a population of brain multigraphs, where each graph (e.g., functional) quantifies a particular relationship between pairs of brain regions of interest (ROIs), allows to pin…

机器学习 · 计算机科学 2021-10-08 Oytun Demirbilek , Islem Rekik

Resting-state brain functional connectivity quantifies the synchrony between activity patterns of different brain regions. In functional magnetic resonance imaging (fMRI), each region comprises a set of spatially contiguous voxels at which…

统计方法学 · 统计学 2025-11-07 Ruobin Liu , Chao Zhang , Chau Tran , Sophie Achard , Wendy Meiring , Alexander Petersen

Studying the cellular architecture of the human cerebral cortex is critical for understanding brain organization and function. It requires investigating complex texture patterns in histological images, yet automatic methods that scale…