相关论文: Validation of nuclear models in Geant4 using the d…

Objective: To develop and validate an independent Monet Carlo dose calculation engine to support for software verification of treatment planning systems and quality assurance workflow. Method: GATE Monte Carlo toolkit was employed to…

The dose distribution of a monoenergetic pencil beam in water consists of an electromagnetic "core", a "halo" from charged nuclear secondaries, and a much larger "aura" from neutral secondaries. These regions overlap, but each has distinct…

Accurate proton dose calculation using Monte Carlo (MC) is computationally demanding in workflows like robust optimisation, adaptive replanning, and probabilistic inference, which require repeated evaluations. To address this, we develop a…

A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It…

We study the propagation of nucleons and nuclei in tissue-like media within a Monte Carlo Model for Heavy-ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.2). The model takes into account fragmentation of projectile nuclei and…

Purpose: To introduce and evaluate the use of stable distributions as a means of describing the behavior of charged particle pencil beams in a medium, with specific emphasis on proton beam scanning (PBS). Methods: The proton pencil beams of…

Purpose: The presence of respiratory motion during radiation treatment leads to degradation of the expected dose distribution, both for target coverage and healthy-tissue sparing, particularly for techniques like pencil-beam scanning proton…

The Monte Carlo (MC) simulation method is a powerful tool for radiation physicists, and several general-purpose software packages are commonly applied in a myriad of different radiation physics fields today. In medical physics, charged…

A radiographic setup for an investigation of fast dynamic processes with areal density of targets up to 5 g/cm$^2$ is under development on the basis of high-current proton linear accelerator at the Institute for Nuclear Research (Troitsk,…

Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…

Objective: To assess the accuracy and computational performance of a stochastic differential equation (SDE)--based model for proton beam dose calculation by benchmarking against Geant4 in simplified phantom geometries. Approach: Building on…

The dose distribution of a pencil beam in water consists of a core, a halo, an aura and (possibly) spray. The core is due to primary protons which suffer multiple Coulomb scattering (MCS) and slow down by multiple collisions with atomic…

In this paper we investigate, with a detailed Monte-Carlo simulation based on Geant4, the novel approach [Nucl. Instrum. Methods A588 (2008) 457] to 3D imaging with photon scattering. A monochromatic and well collimated gamma beam is used…

Purpose: Very fast Monte Carlo (MC) simulations of proton transport have been implemented recently on GPUs. However, these usually use simplified models for non-elastic (NE) proton-nucleus interactions. Our primary goal is to build a…

Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the…

We have developed a model for proton depth dose and lateral distributions based on Monte Carlo calculations (GEANT4) and an integration procedure of the Bethe-Bloch equation (BBE). The model accounts for the transport of primary and…

For the in vivo range verification in proton therapy, it has been tried to measure the spatial distribution of the prompt gammas generated by the proton-induced interactions with the close relationship with the proton dose distribution.…

A version of Geant4 has been developed to treat high-energy proton radiography. This article presents the results of calculations simulating the effects of nuclear elastic scattering for various test step wedges. Comparisons with…

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection system consists of eight LaBr3 scintillators and a tungsten collimator,…

We model the responses of Tissue-Equivalent Proportional Counters (TEPC) to radiation fields of therapeutic C-12 beams in a water phantom and to quasi-monoenergetic neutrons in a PMMA phantom. Simulations are performed with the Monte Carlo…