相关论文: Practical biological spread-out Bragg peak design …
Carbon-ion radiotherapy (CIRT) is generally evaluated with the dose weighted by relative biological effectiveness (RBE), while the radiation quality varying in the body of each patient is ignored for lack of such distribution. In this…
Relative biological effectiveness (RBE) plays an important role in designing a uniform dose response for ion beam therapy. In this study the biological effectiveness of a carbon ion beam delivery system was investigated using Monte Carlo…
Beams of $^{4}$He and $^{16}$O nuclei are considered for ion-beam cancer therapy as alternative options to protons and $^{12}$C nuclei. Spread-out Bragg peak (SOBP) distributions of physical dose and relative biological effectiveness for…
Proton beam radiotherapy stands at the forefront of precision cancer treatment, leveraging the unique physical interactions of proton beams with human tissue to deliver minimal dose upon entry and deposit the therapeutic dose precisely at…
We introduce an approach for global fitting of the recently published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned proton beams. Our fitting procedure accounts for the correlation between the…
We used the GEANT4 Monte Carlo MC Toolkit to simulate carbon ion beams incident on water, tissue, and bone, taking into account nuclear fragmentation reactions. Upon increasing the energy of the primary beam, the position of the Bragg-Peak…
The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics…
Methods: A phase space file in a plane at 202 mm downstream of the beam exit window is generated through tuning parameters to match FDC results with measured or MCNPX Monte Carlo-simulated integrated depth-dose distribution (IDD) and…
Heavy ions have varying effects on the target. The most important factor in comparing this effect is Linear Energy Transfer (LET). Protons and carbons are heavy ions with high LET. Since these ions lose energy through collisions as they…
Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical…
We investigated the parameter optimization of ridge filter thickness using a Monte Carlo simulation for carbon ion therapy. For this study, a ridge filter was designed for the Spread-Out Bragg Peak (SOBP) by considering the relative…
Improving effective treatment plans in carbon ion therapy, especially for targeting radioresistant tumors located in deep seated regions while sparing normal tissues, depends on a precise and computationally efficient dose calculation…
The radiation effects induced by Co60 serve as a reference system for the consideration of LET and RBE in normal and tumor tissue dose-effect relations are usually handled by the linear-quadratic model (LQ). This approximation excellently…
230 MeV proton beam out of a cyclotron was delivered into a Zebra multi layered IC detector (IBA) calibrated in terms of penetration range in water. The analysis of the measured Bragg peak determines penetration range in water which can be…
Arrays of minibeams of protons and $^{12}$C in tissue-like media were modeled with Geant4 toolkit. A set of beam energies was used in simulations to provide a Spead-out Bragg peak (SOBP) extended by 6 cm in depth for protons as well as for…
Carbon ion therapy is one of the most advanced forms of radiotherapy, promising improved efficacy against resistant cancers. However, the high precision offered by the carbon ion Bragg peak requires precise knowledge of the beam range…
The paper discusses some 3D simulations to compute the ionizing radiation dose during laser-plasma experiments leading to the generation of accelerated protons and electrons. Also, we suggest a new method to increase the measurement…
Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues. However, the clinical implementation is…
A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the…
Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of FLASH dose rate have been demonstrated feasible for proton FLASH…