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The Metropolis-Hastings (MH) algorithm is the prototype for a class of Markov chain Monte Carlo methods that propose transitions between states and then accept or reject the proposal. These methods generate a correlated sequence of random…

计算物理 · 物理学 2011-05-12 Albert H. Mao , Rohit V. Pappu

We consider continuous-time, finite-horizon, optimal quadratic control of semi-Markov jump linear systems (S-MJLS), and develop principled approximations through Markov-like representations for the holding-time distributions. We adopt a…

系统与控制 · 计算机科学 2017-11-07 Saeid Jafari , Ketan Savla

In most sampling algorithms, including Hamiltonian Monte Carlo, transition rates between states correspond to the probability of making a transition in a single time step, and are constrained to be less than or equal to 1. We derive a…

机器学习 · 统计学 2015-10-13 Andrew B. Berger , Mayur Mudigonda , Michael R. DeWeese , Jascha Sohl-Dickstein

We introduce a novel and efficient simulation scheme for Hawkes processes on a fixed time grid, leveraging their affine Volterra structure. The key idea is to first simulate the integrated intensity and the counting process using Inverse…

概率论 · 数学 2025-11-18 Eduardo Abi Jaber , Elie Attal , Dimitri Sotnikov

Hidden Markov models (HMMs) are probabilistic functions of finite Markov chains, or, put in other words, state space models with finite state space. In this paper, we examine subspace estimation methods for HMMs whose output lies a finite…

统计理论 · 数学 2009-11-20 Sofia Andersson , Tobias Rydén

We consider the problem of efficiently simulating stochastic models of chemical kinetics. The Gillespie Stochastic Simulation algorithm (SSA) is often used to simulate these models, however, in many scenarios of interest, the computational…

分子网络 · 定量生物学 2024-07-10 Thomas Trigo Trindade , Konstantinos C. Zygalakis

In biochemically reactive systems with small copy numbers of one or more reactant molecules, the dynamics is dominated by stochastic effects. To approximate those systems, discrete state-space and stochastic simulation approaches have been…

数值分析 · 数学 2020-07-13 Chiheb Ben Hammouda , Alvaro Moraes , Raul Tempone

There is much interest in the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM) as a natural Bayesian nonparametric extension of the ubiquitous Hidden Markov Model for learning from sequential and time-series data. However, in…

统计方法学 · 统计学 2012-09-11 Matthew J. Johnson , Alan S. Willsky

Jump Markov linear systems (JMLS) are a useful class which can be used to model processes which exhibit random changes in behavior during operation. This paper presents a numerically stable method for learning the parameters of jump Markov…

应用统计 · 统计学 2020-04-21 Mark P. Balenzuela , Adrian G. Wills , Christopher Renton , Brett Ninness

The Harrow-Hassidim-Lloyd (HHL) algorithm is a quantum algorithm for solving systems of linear equations that, in principle, offers an exponential improvement in scaling with the system size compared to classical approaches. In this work,…

量子物理 · 物理学 2026-03-18 Dhruv Sood , Nilmani Mathur , Vikram Tripathi

This paper is concerned with the computational complexity of learning the Hidden Markov Model (HMM). Although HMMs are some of the most widely used tools in sequential and time series modeling, they are cryptographically hard to learn in…

机器学习 · 计算机科学 2024-02-27 Sham M. Kakade , Akshay Krishnamurthy , Gaurav Mahajan , Cyril Zhang

Single-cell data reveal the presence of biological stochasticity between cells of identical genome and environment, in particular highlighting the transcriptional bursting phenomenon. To account for this property, gene expression may be…

分子网络 · 定量生物学 2026-05-19 Mathilde Gaillard , Ulysse Herbach

This paper studies a non-random-walk Markov Chain Monte Carlo method, namely the Hamiltonian Monte Carlo (HMC) method in the context of Subset Simulation used for structural reliability analysis. The HMC method relies on a deterministic…

统计计算 · 统计学 2018-04-20 Ziqi Wang , Marco Broccardo , Junho Song

Models of reaction chemistry based on the stochastic simulation algorithm (SSA) have become a crucial tool for simulating complicated biological reaction networks due to their ability to handle extremely complicated reaction networks and to…

定量方法 · 定量生物学 2009-11-13 Navodit Misra , Russell Schwartz

Hamiltonian Monte Carlo (HMC) sampling methods provide a mechanism for defining distant proposals with high acceptance probabilities in a Metropolis-Hastings framework, enabling more efficient exploration of the state space than standard…

统计方法学 · 统计学 2014-05-13 Tianqi Chen , Emily B. Fox , Carlos Guestrin

The Half-Space Matching (HSM) method has recently been developed as a new method for the solution of 2D scattering problems with complex backgrounds, providing an alternative to Perfectly Matched Layers (PML) or other artificial boundary…

The hidden Markov model (HMM) provides a powerful framework for inference in time-varying environments, where the underlying state evolves according to a Markov chain. To address the optimal filtering problem in general dynamic settings, we…

系统与控制 · 电气工程与系统科学 2025-06-10 Dongyan Sui , Haotian Pu , Siyang Leng , Stefan Vlaski

The stochastic simulation algorithm (SSA) is widely used to perform exact forward simulation of discrete stochastic processes in biology. However, the computational cost, driven by sequential event-by-event sampling across large ensembles,…

定量方法 · 定量生物学 2026-05-04 Tom Kimpson , Mark B. Flegg , Jennifer A. Flegg

We aim at the construction of a Hidden Markov Model (HMM) of assigned complexity (number of states of the underlying Markov chain) which best approximates, in Kullback-Leibler divergence rate, a given stationary process. We establish, under…

最优化与控制 · 数学 2014-07-03 Lorenzo Finesso , Angela Grassi , Peter Spreij

This is a method for discrete event simulation specified by survival analysis. It presents a sequence of steps. First, hazard rates from survival analysis specify the rates of a set of counting processes. Second, those counting processes…

统计计算 · 统计学 2016-10-14 Andrew J. Dolgert