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OBJECTIVE: This study evaluated the accuracy in localisation and distribution of real-time three-dimensional (4-D) ultrasound-guided biopsies on a prostate phantom. METHODS: A prostate phantom was created. A three-dimensional real-time…

The main treatment modality for oropharyngeal cancer (OPC) is radiotherapy, where accurate segmentation of the primary gross tumor volume (GTVp) is essential. However, accurate GTVp segmentation is challenging due to significant…

The problem of chemotherapy treatment optimization can be defined in order to minimize the size of the tumor without endangering the patient's health; therefore, chemotherapy requires to achieve a number of objectives, simultaneously. For…

神经与进化计算 · 计算机科学 2023-03-21 Mina Jafari , Behnam Ghavami , Vahid Sattari Naeini

Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by improving normal tissue sparing while maintaining the same…

Contrast-enhanced (CE) T1-weighted MRI is central to neuro-oncologic diagnosis but requires gadolinium-based agents, which add cost and scan time, raise environmental concerns, and may pose risks to patients. In this work, we propose a…

计算机视觉与模式识别 · 计算机科学 2025-08-19 Bastian Brandstötter , Erich Kobler

Topological materials (TMs) are well-known for their topological protected properties. Phononic system has the advantage of direct observation and engineering of topological phenomena on the macroscopic scale. For the inverse design of 3D…

应用物理 · 物理学 2023-06-14 Jiachen Luo , Zongliang Du , Hui Chen , Xianggui Ding , Chang Liu , Weisheng Zhang , Xu Guo

$\textbf{Purpose:}$ To assess the viability of a physics-based, deterministic and adjoint-capable algorithm for performing treatment planning system independent dose calculations and for computing dosimetric differences caused by anatomical…

医学物理 · 物理学 2024-04-02 Tiberiu Burlacu , Danny Lathouwers , Zoltán Perkó

Objective: Mapping of transrectal ultrasonographic (TRUS) prostate biopsies is of fundamental importance for either diagnostic purposes or the management and treatment of prostate cancer, but the localization of the cores seems inaccurate.…

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

医学物理 · 物理学 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

Although optimal control theory has been used for the theoretical study of anti-cancerous drugs scheduling optimization, with the aim of reducing the primary tumor volume, the effect on metastases is often ignored. Here, we use a previously…

组织与器官 · 定量生物学 2013-06-21 Sebastien Benzekry , Philip Hahnfeldt

In this study, we present pituitary adenoma volumetry using the free and open source medical image computing platform for biomedical research: (3D) Slicer. Volumetric changes in cerebral pathologies like pituitary adenomas are a critical…

计算机视觉与模式识别 · 计算机科学 2012-12-13 Jan Egger , Tina Kapur , Christopher Nimsky , Ron Kikinis

Precise patient positioning and thus precise positioning of the planning target volume (PTV) is a prerequisite for effective treatment in percutaneous radiation therapy. Conventional imaging modalities used to ensure exact positioning for…

医学物理 · 物理学 2016-02-12 Manfred Wiencierz , Kathrin Kruppa , Lutz Lüdemann

Malignant pleural mesothelioma (MPM) is the most common form of mesothelioma. To assess response to treatment, tumor measurements are acquired and evaluated based on a patient's longitudinal computed tomography (CT) scans. Tumor volume,…

Head and neck tumors and metastatic lymph nodes are crucial for treatment planning and prognostic analysis. Accurate segmentation and quantitative analysis of these structures require pixel-level annotation, making automated segmentation…

图像与视频处理 · 电气工程与系统科学 2025-04-01 Litingyu Wang , Wenjun Liao , Shichuan Zhang , Guotai Wang

Panoramic radiograph (PR) is fundamentally used in routine dental care, but it inherently provides only a two-dimensional (2D) projection of complex three-dimensional (3D) craniofacial anatomy. Most existing learning-based methods attempt…

计算机视觉与模式识别 · 计算机科学 2026-05-21 Yaoyao Yue , Jérôme Schmid , Xiaoshuang Li , Eduardo Delamare , Jinman Kim

We propose to develop deep learning models that can predict Pareto optimal dose distributions by using any given set of beam angles, along with patient anatomy, as input to train the deep neural networks. We implement and compare two deep…

医学物理 · 物理学 2021-01-27 Gyanendra Bohara , Azar Sadeghnejad Barkousaraie , Steve Jiang , Dan Nguyen

In radiotherapy, 2D orthogonally projected kV images are used for patient alignment when 3D-on-board imaging(OBI) unavailable. But tumor visibility is constrained due to the projection of patient's anatomy onto a 2D plane, potentially…

Fluence map optimization for intensity-modulated radiation therapy planning can be formulated as a large-scale inverse problem with competing objectives and constraints associated with the tumors and organs-at-risk. Unfortunately,…

最优化与控制 · 数学 2022-02-17 Kelsey Maass , Minsun Kim , Aleksandr Aravkin

Radiotherapy is the main treatment modality for nasopharynx cancer. Delineation of Gross Target Volume (GTV) from medical images such as CT and MRI images is a prerequisite for radiotherapy. As manual delineation is time-consuming and…

图像与视频处理 · 电气工程与系统科学 2021-01-28 Haochen Mei , Wenhui Lei , Ran Gu , Shan Ye , Zhengwentai Sun , Shichuan Zhang , Guotai Wang

Background and Objective: To assess the feasibility and accuracy of reconstructing time-resolved, three-dimensional, subject-specific aortic geometries from a limited number of standard cine 2D magnetic resonance imaging (MRI) acquisitions.…

图像与视频处理 · 电气工程与系统科学 2026-04-01 Gloria Wolkerstorfer , Stefano Buoso , Rabea Schlenker , Jochen von Spiczak , Robert Manka , Sebastian Kozerke