相关论文: Extraction of Protein Sequence Motif Information u…

Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing…

Data clustering is a recognized data analysis method in data mining whereas K-Means is the well known partitional clustering method, possessing pleasant features. We observed that, K-Means and other partitional clustering techniques suffer…

The main objective of the Multiple Kernel k-Means (MKKM) algorithm is to extract non-linear information and achieve optimal clustering by optimizing base kernel matrices. Current methods enhance information diversity and reduce redundancy…

Feature selection is an important and challenging task in high dimensional clustering. For example, in genomics, there may only be a small number of genes that are differentially expressed, which are informative to the overall clustering…

Given a point set S and an unknown metric d on S, we study the problem of efficiently partitioning S into k clusters while querying few distances between the points. In our model we assume that we have access to one versus all queries that…

Background: Exonic splice enhancers are sequences embedded within exons which promote and regulate the splicing of the transcript in which they are located. A class of exonic splice enhancers are the SR proteins, which are thought to…

Clustering data is a popular feature in the field of unsupervised machine learning. Most algorithms aim to find the best method to extract consistent clusters of data, but very few of them intend to cluster data that share the same…

This paper proposes the use of an optimization algorithm, namely PSO to decide the initial centroids in K-means, to eventually get better accuracy. The vectorized notation of the optimal centroids can be thought of as entities in an…

The learning of mixture models can be viewed as a clustering problem. Indeed, given data samples independently generated from a mixture of distributions, we often would like to find the {\it correct target clustering} of the samples…

Clustering, a fundamental activity in unsupervised learning, is notoriously difficult when the feature space is high-dimensional. Fortunately, in many realistic scenarios, only a handful of features are relevant in distinguishing clusters.…

Detecting PE malware files is now commonly approached using statistical and machine learning models. While these models commonly use features extracted from the structure of PE files, we propose that icons from these files can also help…

Given a point set S and an unknown metric d on S, we study the problem of efficiently partitioning S into k clusters while querying few distances between the points. In our model we assume that we have access to one versus all queries that…

Kernel $k$-means clustering is a powerful tool for unsupervised learning of non-linearly separable data. Since the earliest attempts, researchers have noted that such algorithms often become trapped by local minima arising from…

Protein-protein interaction (PPI) extraction from published scientific literature provides additional support for precision medicine efforts. Meanwhile, knowledge bases (KBs) contain huge amounts of structured information of protein…

Genome sequencing projects are rapidly increasing the number of high-dimensional protein sequence datasets. Clustering a high-dimensional protein sequence dataset using traditional machine learning approaches poses many challenges. Many…

Knowledge discovery is one of the main goals of Artificial Intelligence. This Knowledge is usually stored in databases spread in different environments, being a tedious (or impossible) task to access and extract data from them. To this…

The discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from existing approaches are not necessarily…

In this paper, we address the problem of identifying protein functionality using the information contained in its aminoacid sequence. We propose a method to define sequence similarity relationships that can be used as input for…

Protein language models have emerged as powerful tools for sequence generation, offering substantial advantages in functional optimization and denovo design. However, these models also present significant risks of generating harmful protein…

Text extraction is a highly subjective problem which depends on the dataset that one is working on and the kind of summarization details that needs to be extracted out. All the steps ranging from preprocessing of the data, to the choice of…