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Robins (1998) introduced marginal structural models (MSMs), a general class of counterfactual models for the joint effects of time-varying treatment regimes in complex longitudinal studies subject to time-varying confounding. He established…

统计方法学 · 统计学 2018-09-17 Eric J Tchetgen Tchetgen , Haben Michael , Yifan Cui

Structured Latent Attribute Models (SLAMs) are a family of discrete latent variable models widely used in education, psychology, and epidemiology to model multivariate categorical data. A SLAM assumes that multiple discrete latent…

统计方法学 · 统计学 2021-07-12 Yuqi Gu , Gongjun Xu

In the standard difference-in-differences research design, the parallel trends assumption may be violated when the relationship between the exposure trend and the outcome trend is confounded by unmeasured confounders. Progress can be made…

Instrumental variable methods are fundamental to causal inference when treatment assignment is confounded by unobserved variables. In this article, we develop a general nonparametric causal framework for identification and learning with…

统计方法学 · 统计学 2026-02-10 Shuyuan Chen , Peng Zhang , Yifan Cui

Marginal structural models (MSMs) are often used to estimate causal effects of treatments on survival time outcomes from observational data when time-dependent confounding may be present. They can be fitted using, e.g., inverse probability…

统计方法学 · 统计学 2023-12-27 Shaun R Seaman , Ruth H Keogh

The conditional moment problem is a powerful formulation for describing structural causal parameters in terms of observables, a prominent example being instrumental variable regression. A standard approach reduces the problem to a finite…

机器学习 · 计算机科学 2023-03-24 Andrew Bennett , Nathan Kallus

With recent advances in sequencing technologies, large amounts of epigenomic data have become available and computational methods are contributing significantly to the progress of epigenetic research. As an orthogonal approach to methods…

基因组学 · 定量生物学 2019-11-05 Alexander Lück , Verena Wolf

Instrumental variables are a popular tool to infer causal effects under unobserved confounding, but choosing suitable instruments is challenging in practice. We propose gIVBMA, a Bayesian model averaging procedure that addresses this…

统计方法学 · 统计学 2026-03-02 Gregor Steiner , Mark Steel

Many applications in mechanical, acoustic, and electronic engineering require estimating complex dynamical models, often represented as additive multi-input multi-output (MIMO) transfer functions with structural constraints. This paper…

系统与控制 · 电气工程与系统科学 2025-05-21 Rodrigo A. González , Maarten van der Hulst , Koen Classens , Tom Oomen

Structural causal models (SCMs) are widely used in various disciplines to represent causal relationships among variables in complex systems. Unfortunately, the underlying causal structure is often unknown, and estimating it from data…

机器学习 · 计算机科学 2024-01-17 Tianyu Chen , Kevin Bello , Bryon Aragam , Pradeep Ravikumar

In longitudinal studies, time-varying covariates are often endogenous, meaning their values depend on both their own history and that of the outcome variable. This violates key assumptions of Generalized Linear Mixed Effects Models (GLMMs),…

Structural Nested Mean Models (SNMMs) are useful for causal inference of treatment effects in longitudinal observational studies. Most existing works assume that the data are collected at pre-fixed time points for all subjects, which,…

统计方法学 · 统计学 2020-01-13 Shu Yang

Measurement error is ubiquitous in many variables - from blood pressure recordings in physiology to intelligence measures in psychology. Structural equation models (SEMs) account for the process of measurement by explicitly distinguishing…

统计方法学 · 统计学 2023-02-28 Ankur Ankan , Inge Wortel , Kenneth A. Bollen , Johannes Textor

We consider mediated effects of an exposure, X on an outcome, Y, via a mediator, M, under no unmeasured confounding assumptions in the setting where models for the conditional expectation of the mediator and outcome are partially linear. We…

统计方法学 · 统计学 2025-01-08 Oliver Hines , Stijn Vansteelandt , Karla Diaz-Ordaz

Methods utilizing instrumental variables have been a fundamental statistical approach to estimation in the presence of unmeasured confounding, usually occurring in non-randomized observational data common to fields such as economics and…

统计方法学 · 统计学 2022-10-06 Charles Spanbauer , Wei Pan

Mendelian randomization (MR) is a widely-used method to estimate the causal relationship between a risk factor and disease. A fundamental part of any MR analysis is to choose appropriate genetic variants as instrumental variables.…

统计方法学 · 统计学 2023-04-26 Ashish Patel , Francis J. DiTraglia , Verena Zuber , Stephen Burgess

In finite samples, the use of a slightly endogenous but highly relevant instrument can reduce mean-squared error (MSE). Building on this observation, I propose a novel moment selection procedure for GMM -- the Focused Moment Selection…

统计方法学 · 统计学 2026-02-24 Francis J. DiTraglia

Mendelian randomization is the use of genetic variants to make causal inferences from observational data. The field is currently undergoing a revolution fuelled by increasing numbers of genetic variants demonstrated to be associated with…

统计方法学 · 统计学 2018-08-31 Stephen Burgess , Jack Bowden , Frank Dudbridge , Simon G Thompson

In industrial experiments, controlling variability is of paramount importance to ensure product quality. Classical regression models for mixture experiments are widely used in industry, however, when the assumption of constant variance is…

统计方法学 · 统计学 2022-06-07 Edmilson Rodrigues Pinto , Leandro Alves Pereira

Instrumental variables are a popular study design for the estimation of treatment effects in the presence of unobserved confounders. In the canonical instrumental variables design, the instrument is a binary variable. In many settings,…

统计方法学 · 统计学 2024-10-10 Prabrisha Rakshit , Alexander Levis , Luke Keele