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This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined…

统计计算 · 统计学 2022-07-19 William Consagra , Martin Cole , Zhengwu Zhang

The human brain is a complex network comprised of functionally and anatomically interconnected brain regions. A growing number of studies have suggested that empirical estimates of brain networks may be useful for discovery of biomarkers of…

神经元与认知 · 定量生物学 2022-11-15 Andrew Hannum , Mario A. Lopez , Saúl A. Blanco , Richard F. Betzel

Brain networks characterize complex connectivities among brain regions as graph structures, which provide a powerful means to study brain connectomes. In recent years, graph neural networks have emerged as a prevalent paradigm of learning…

机器学习 · 计算机科学 2022-06-10 Yi Yang , Yanqiao Zhu , Hejie Cui , Xuan Kan , Lifang He , Ying Guo , Carl Yang

This paper considers the problem of brain disease classification based on connectome data. A connectome is a network representation of a human brain. The typical connectome classification problem is very challenging because of the small…

This manuscript presents a novel, tightly integrated pipeline for estimating a connectome, which is a comprehensive description of the neural circuits in the brain. The pipeline utilizes magnetic resonance imaging (MRI) data to produce a…

Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

神经元与认知 · 定量生物学 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Investigations of the human connectome have elucidated core features of adult structural networks, particularly the crucial role of hub-regions. However, little is known regarding network organisation of the healthy elderly connectome, a…

神经元与认知 · 定量生物学 2015-12-15 Alistair Perry , Wei Wen , Anton Lord , Anbupalam Thalamuthu , Perminder Sachdev , Michael Breakspear

Determining important vertices in large graphs (e.g., Google's PageRank in the case of the graph of the World Wide Web) facilitated the construction of excellent web search engines, returning the most important hits corresponding to the…

神经元与认知 · 定量生物学 2021-07-06 Laszlo Keresztes , Evelin Szogi , Balint Varga , Vince Grolmusz

Individual differences in human intelligence can be modeled and predicted from in vivo neurobiological connectivity. Many established modeling frameworks for predicting intelligence, however, discard higher-order information about…

Brain function and connectivity is a pressing mystery in medicine related to many diseases. Neural connectomes have been studied as graphs with graph theory methods including topological methods. Work has started on hypergraph models and…

统计方法学 · 统计学 2022-05-09 Michael G. Rawson

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

神经元与认知 · 定量生物学 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

The assessment of brain fingerprints has emerged in the recent years as an important tool to study individual differences and to infer quality of neuroimaging datasets. Studies so far have mainly focused on connectivity fingerprints between…

神经元与认知 · 定量生物学 2021-01-13 Uttara Tipnis , Kausar Abbas , Elizabeth Tran , Enrico Amico , Li Shen , Alan D. Kaplan , Joaquín Goñi

In this thesis, we present robust and fully-automated methods for the subdivision of the entire human cerebral cortex based on connectivity information. Our contributions are four-fold: First, we propose a clustering approach to delineate a…

神经元与认知 · 定量生物学 2018-02-21 Salim Arslan

The dynamic characteristics of functional network connectivity have been widely acknowledged and studied. Both shared and unique information has been shown to be present in the connectomes. However, very little has been known about whether…

神经元与认知 · 定量生物学 2020-06-18 Biao Cai , Gemeng Zhang , Aiying Zhang , Li Xiao , Wenxing Hu , Julia M. Stephen , Tony W. Wilson , Vince D. Calhoun , Yu-Ping Wang

Understanding how cortex, subcortex and cerebellum integrate is a major challenge for neuroscience, however, studies of the brain's structural connectivity have mostly focused on cortico-cortical links. Here, we used diffusion imaging to…

神经元与认知 · 定量生物学 2025-10-21 Julian Schulte , Mario Senden , Gustavo Deco , Xenia Kobeleva , Gorka Zamora-López

Visually comparing brain networks, or connectomes, is an essential task in the field of neuroscience. Especially relevant to the field of clinical neuroscience, group studies that examine differences between populations or changes over time…

神经元与认知 · 定量生物学 2017-07-03 Johnson J. G. Keiriz , Liang Zhan , Morris Chukhman , Olu Ajilore , Alex D. Leow , Angus G. Forbes

The architecture of the human connectome supports efficient communication protocols relying either on distances between brain regions or on the intensities of connections. However, none of these protocols combines information about the two…

神经元与认知 · 定量生物学 2024-10-07 Laia Barjuan , Jordi Soriano , M. Ángeles Serrano

We describe a scalable database cluster for the spatial analysis and annotation of high-throughput brain imaging data, initially for 3-d electron microscopy image stacks, but for time-series and multi-channel data as well. The system was…

Recent work in mathematical neuroscience has calculated the directed graph homology of the directed simplicial complex given by the brains sparse adjacency graph, the so called connectome. These biological connectomes show an abundance of…

组合数学 · 数学 2023-01-30 Florian Unger , Jonathan Krebs , Michael G. Müller

Graph theoretical analyses have become standard tools in modeling functional and anatomical connectivity in the brain. With the advent of connectomics, the primary graphs or networks of interest are structural connectome (derived from DTI…

神经元与认知 · 定量生物学 2022-07-07 Carlo Amodeo , Igor Fortel , Olusola Ajilore , Liang Zhan , Alex Leow , Theja Tulabandhula