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We present Defocusing Microscopy (DM), a bright-field optical microscopy technique able to perform total 3D imaging of transparent objects. By total 3D imaging we mean the determination of the actual shapes of the upper and lower surfaces…

生物物理 · 物理学 2015-06-19 P. M. S. Roma , L. Siman , F. T. Amaral , U. Agero , O. N. Mesquita

Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…

医学物理 · 物理学 2023-09-28 Yu-Hsiang Chang , Yang-Hsien Lin , Kung-Bin Sung

We investigate the problem of 3D complex field reconstruction corresponding to unstained red blood cells (RBCs) with a single defocused off-axis digital hologram. We employ recently introduced mean gradient descent (MGD) optimization…

图像与视频处理 · 电气工程与系统科学 2023-03-22 Sunaina Rajora , Mansi Butola , Kedar Khare

Modeling of the red blood cell (RBC) shape is an integral part of the experimental and computer simulation investigations of light scattering by these cells for fundamental studies as well as diagnostic applications in techniques like…

生物物理 · 物理学 2024-06-18 Gaurav D. Bhabhor , Chetna Patel , Nishant Chhillar , Arun Anand , Kirit N. Lad

Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…

软凝聚态物质 · 物理学 2023-02-22 Qi Chen , Naval Singh , Kerstin Schirrmann , Qi Zhou , Igor Chernyavsky , Anne Juel

We propose a modified suspension balance model (SBM) for the flow of red blood cells (RBCs) and other deformable particle suspensions in confined geometries. Specifically, the method includes the hydrodynamic lift force generated by…

Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions for fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a…

We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC…

细胞行为 · 定量生物学 2009-05-04 Dmitry A. Fedosov , Bruce Caswell , George E. Karniadakis

We show, via three-dimensional immersed-boundary-finite-element-lattice-Boltzmann simulations, that deformability-based red blood cell (RBC) separation in deterministic lateral displacement (DLD) devices is possible. This is due to the…

软凝聚态物质 · 物理学 2016-03-15 Timm Krüger , David Holmes , Peter V. Coveney

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

医学物理 · 物理学 2011-07-26 Simone Melchionna

Reconstruction of 3D erythrocyte or red blood cell (RBC) morphology from partial observations, such as microscope images, is essential for understanding the physiology of RBC aging and the pathology of various RBC disorders. In this study,…

计算物理 · 物理学 2025-11-20 Haizhou Wen , He Li , Zhen Li

The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusion. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were…

医学物理 · 物理学 2015-06-30 HyunJoo Park , Misook Ji , SangYun Lee , Kyoohyun Kim , Yong-Hak Sohn , Seongsoo Jang , YongKeun Park

We investigate the potential of second generation measurements of redshifted 21 cm radiation from before and during the epoch of reionization (EOR) to reconstruct the matter density fluctuations along the line of sight. To do so we…

天体物理学 · 物理学 2008-11-26 Oliver Zahn , Matias Zaldarriaga

In medical imaging, the diffusion models have shown great potential for synthetic image generation tasks. However, these approaches often lack the interpretable connections between the generated and real images and can create anatomically…

图像与视频处理 · 电气工程与系统科学 2026-02-12 Jian-Qing Zheng , Yuanhan Mo , Yang Sun , Jiahua Li , Fuping Wu , Ziyang Wang , Tonia Vincent , Bartłomiej W. Papież

We investigate the dynamics of the Red Blood Cell (RBC) in microfluidic channels under oscillatory flows. The simulations employ a hybrid continuum-particle approach, in which the cell membrane and cytosol fluid are modeled using…

流体动力学 · 物理学 2023-07-18 Lahcen Akerkouch , Trung Bao Le

It is important to understand the dynamics of red blood cells (RBCs) in blood flow. This requires the formulation of coarse-grained RBC models that reproduce the hydrodynamic properties of blood accurately. One of the models that…

软凝聚态物质 · 物理学 2024-10-15 Tetsuya Yamamoto , Hiroshi Watanabe

The deformability of human red blood cells (RBCs), which comprise almost 99% of the cells in whole blood, is largely related not only to pathophysiological blood flow but also to the levels of intracellular compounds. Therefore, statistical…

流体动力学 · 物理学 2024-10-08 Naoki Takeishi , Tomohiro Nishiyama , Kodai Nagaishi , Takeshi Nashima , Masako Sugihara-Seki

Detail features of magnetic resonance images play a cru-cial role in accurate medical diagnosis and treatment, as they capture subtle changes that pose challenges for doc-tors when performing precise judgments. However, the widely utilized…

计算机视觉与模式识别 · 计算机科学 2024-05-10 Mengxiao Geng , Jiahao Zhu , Xiaolin Zhu , Qiqing Liu , Dong Liang , Qiegen Liu

In this work, we review previously developed coarse-grained (CG) particle models for biological membrane and red blood cells (RBCs) and discuss the advantages of the CG particle method over the continuum and atomic simulations on modeling…

软凝聚态物质 · 物理学 2017-07-18 He Li , Hung-yu Chang , Jun Yang , Lu Lu , George Lykotrafitis

We present a computational framework for the simulation of blood flow with fully resolved red blood cells (RBCs) using a modular approach that consists of a lattice Boltzmann solver for the blood plasma, a novel finite element based solver…

计算物理 · 物理学 2019-08-28 Christos Kotsalos , Jonas Latt , Bastien Chopard
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