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Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

神经元与认知 · 定量生物学 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

计算工程、金融与科学 · 计算机科学 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

In this paper, we describe our method for classification of brain magnetic resonance (MR) images into different abnormalities and healthy classes based on the deep neural network. We propose our method to detect high and low-grade glioma,…

计算机视觉与模式识别 · 计算机科学 2017-08-18 Mina Rezaei , Haojin Yang , Christoph Meinel

Structural connectivity in the brain is typically studied by reducing its observation to a single spatial resolution. However, the brain possesses a rich architecture organized over multiple scales linked to one another. We explored the…

物理与社会 · 物理学 2020-09-07 Muhua Zheng , Antoine Allard , Patric Hagmann , Yasser Alemán-Gómez , M. Ángeles Serrano

Synaptic connectivity detection is a critical task for neural reconstruction from Electron Microscopy (EM) data. Most of the existing algorithms for synapse detection do not identify the cleft location and direction of connectivity…

计算机视觉与模式识别 · 计算机科学 2018-10-26 Toufiq Parag , Daniel Berger , Lee Kamentsky , Benedikt Staffler , Donglai Wei , Moritz Helmstaedter , Jeff W. Lichtman , Hanspeter Pfister

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

神经元与认知 · 定量生物学 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

Human brain atlases provide spatial reference systems for data characterizing brain organization at different levels, coming from different brains. Cytoarchitecture is a basic principle of the microstructural organization of the brain, as…

图像与视频处理 · 电气工程与系统科学 2021-07-07 Christian Schiffer , Hannah Spitzer , Kai Kiwitz , Nina Unger , Konrad Wagstyl , Alan C. Evans , Stefan Harmeling , Katrin Amunts , Timo Dickscheid

Matrices are two-dimensional data structures allowing one to conceptually organize information. For example, adjacency matrices are useful to store the links of a network; correlation matrices are simple ways to arrange gene co-expression…

无序系统与神经网络 · 物理学 2022-09-29 Flaviano Morone

Neuropsychiatric disorders impact functional connectivity of the brain at the network level. The identification and statistical testing of disorder-related networks remains challenging. We propose novel methods to streamline the detection…

应用统计 · 统计学 2017-01-16 Shuo Chen , Yishi Xing , Jian Kang , Dinesh Shukla , Peter Kochunov , L. Elliot Hong

Connectomes are spatially embedded networks whose architecture has been shaped by physical constraints and communication needs throughout evolution. Using a decentralized navigation protocol, we investigate the relationship between the…

神经元与认知 · 定量生物学 2020-02-07 Antoine Allard , M. Ángeles Serrano

The segmentation module which precisely outlines the nodules is a crucial step in a computer-aided diagnosis(CAD) system. The most challenging part of such a module is how to achieve high accuracy of the segmentation, especially for the…

图像与视频处理 · 电气工程与系统科学 2022-02-09 Xinliang Fu , Jiayin Zheng , Juanyun Mai , Yanbo Shao , Minghao Wang , Linyu Li , Zhaoqi Diao , Yulong Chen , Jianyu Xiao , Jian You , Airu Yin , Yang Yang , Xiangcheng Qiu , Jinsheng Tao , Bo Wang , Hua Ji

Identify the cells' nuclei is the important point for most medical analyses. To assist doctors finding the accurate cell' nuclei location automatically is highly demanded in the clinical practice. Recently, fully convolutional neural…

计算机视觉与模式识别 · 计算机科学 2019-11-25 Tianyang Zhang , Rui Ma

Producing connectomes from electron microscopy (EM) images has historically required a great deal of human proofreading effort. This manual annotation cost is the current bottleneck in scaling EM connectomics, for example, in making larger…

计算机视觉与模式识别 · 计算机科学 2025-10-01 Gary B Huang , William M Katz , Stuart Berg , Louis Scheffer

Training segmentation models from scratch has been the standard approach for new electron microscopy connectomics datasets. However, leveraging pretrained models from existing datasets could improve efficiency and performance in constrained…

计算机视觉与模式识别 · 计算机科学 2025-03-11 Shashata Sawmya , Thomas L. Athey , Gwyneth Liu , Nir Shavit

Classification of biological neuron types and networks poses challenges to the full understanding of the brain's organisation and functioning. In this paper, we develop a novel objective classification model of biological neuronal types and…

神经元与认知 · 定量生物学 2020-03-31 Michael Taynnan Barros , Harun Siljak , Peter Mullen , Constantinos Papadias , Jari Hyttinen , Nicola Marchetti

Cerebral Microbleeds (CMBs) are chronic deposits of small blood products in the brain tissues, which have explicit relation to various cerebrovascular diseases depending on their anatomical location, including cognitive decline,…

图像与视频处理 · 电气工程与系统科学 2023-06-27 Jun-Ho Kim , Young Noh , Haejoon Lee , Seul Lee , Woo-Ram Kim , Koung Mi Kang , Eung Yeop Kim , Mohammed A. Al-masni , Dong-Hyun Kim

Cerebellar-like networks, in which input activity patterns are separated by projection to a much higher-dimensional space before classification, are a recurring neurobiological motif, present in the cerebellum, dentate gyrus, insect…

神经元与认知 · 定量生物学 2026-03-23 William Dorrell , Peter E. Latham

We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently…

机器学习 · 计算机科学 2020-04-27 Chun-Ren Phang , Chee-Ming Ting , Fuad Noman , Hernando Ombao

Identifying cell types and understanding their functional properties is crucial for unraveling the mechanisms underlying perception and cognition. In the retina, functional types can be identified by carefully selected stimuli, but this…

We present two related methods for deriving connectivity-based brain atlases from individual connectomes. The proposed methods exploit a previously proposed dense connectivity representation, termed continuous connectivity, by first…

神经元与认知 · 定量生物学 2018-08-14 Anvar Kurmukov , Ayagoz Mussabayeva , Yulia Denisova , Daniel Moyer , Boris Gutman