相关论文: Map-Reduce Parallelization of Motif Discovery

Genomics is the critical key to enabling precision medicine, ensuring global food security and enforcing wildlife conservation. The massive genomic data produced by various genome sequencing technologies presents a significant challenge for…

De novo discovery of over-represented DNA motifs is one of the major challenges in computational biology. Although numerous tools have been available for de novo motif discovery, many of these tools are subject to local optima phenomena,…

Background: Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual's susceptibility to hereditary and complex diseases and affect how our…

Learning the unique directed acyclic graph corresponding to an unknown causal model is a challenging task. Methods based on functional causal models can identify a unique graph, but either suffer from the curse of dimensionality or impose…

Graph embeddings play a critical role in graph representation learning, allowing machine learning models to explore and interpret graph-structured data. However, existing methods often rely on opaque, high-dimensional embeddings, limiting…

Designing biological sequences that satisfy multiple, often conflicting, functional and biophysical criteria remains a central challenge in biomolecule engineering. While discrete flow matching models have recently shown promise for…

The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

Subsequence matching has appeared to be an ideal approach for solving many problems related to the fields of data mining and similarity retrieval. It has been shown that almost any data class (audio, image, biometrics, signals) is or can be…

Dense regions in networks are an indicator of interesting and unusual information. However, most existing methods only consider simple, undirected, unweighted networks. Complex networks in the real-world often have rich information though:…

Higher-order graph clustering aims to partition the graph using frequently occurring subgraphs. Motif conductance is one of the most promising higher-order graph clustering models due to its strong interpretability. However, existing motif…

Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing…

In this paper, we propose a new framework for designing fast parallel algorithms for fundamental statistical subset selection tasks that include feature selection and experimental design. Such tasks are known to be weakly submodular and are…

RNA design aims to find a sequence that folds with highest probability into a designated target structure. However, certain structures are undesignable, meaning no sequence can fold into the target structure under the default (Turner) RNA…

We show that utilizing attribution maps for training neural networks can improve regularization of models and thus increase performance. Regularization is key in deep learning, especially when training complex models on relatively small…

A critical step of genome sequence analysis is the mapping of sequenced DNA fragments (i.e., reads) collected from an individual to a known linear reference genome sequence (i.e., sequence-to-sequence mapping). Recent works replace the…

As an increasing number of genome-wide association studies reveal the limitations of attempting to explain phenotypic heritability by single genetic loci, there is growing interest for associating complex phenotypes with sets of genetic…

Cross-Domain Recommendation (CDR) stands as a pivotal technology addressing issues of data sparsity and cold start by transferring general knowledge from the source to the target domain. However, existing CDR models suffer limitations in…

As networks continue to increase in size, current methods must be capable of handling large numbers of nodes and edges in order to be practically relevant. Instead of working directly with the entire (large) network, analyzing sub-networks…

The identification and counting of small graph patterns, called network motifs, is a fundamental primitive in the analysis of networks, with application in various domains, from social networks to neuroscience. Several techniques have been…

Autonomous technology, which has become widespread today, appears in many different configurations such as mobile robots, manipulators, and drones. One of the most important tasks of these vehicles during autonomous operations is path…