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Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

硬件体系结构 · 计算机科学 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Deep learning training at scale is resource-intensive and time-consuming, often running across hundreds or thousands of GPUs for weeks or months. Efficient checkpointing is crucial for running these workloads, especially in multi-tenant…

分布式、并行与集群计算 · 计算机科学 2025-02-25 Radostin Stoyanov , Viktória Spišaková , Jesus Ramos , Steven Gurfinkel , Andrei Vagin , Adrian Reber , Wesley Armour , Rodrigo Bruno

As GPUs scale their low precision matrix math throughput to boost deep learning (DL) performance, they upset the balance between math throughput and memory system capabilities. We demonstrate that converged GPU design trying to address…

硬件体系结构 · 计算机科学 2021-04-07 Yaosheng Fu , Evgeny Bolotin , Niladrish Chatterjee , David Nellans , Stephen W. Keckler

Genome assembly using high throughput data with short reads, arguably, remains an unresolvable task in repetitive genomes, since when the length of a repeat exceeds the read length, it becomes difficult to unambiguously connect the flanking…

定量方法 · 定量生物学 2013-07-31 Viraj Deshpande , Eric DK Fung , Son Pham , Vineet Bafna

Multiple Sequences Alignment (MSA) of biological sequences is a fundamental problem in computational biology due to its critical significance in wide ranging applications including haplotype reconstruction, sequence homology, phylogenetic…

分布式、并行与集群计算 · 计算机科学 2009-05-13 Fahad Saeed , Ashfaq Khokhar

Range minimum queries are frequently used in string processing and database applications including biological sequence analysis, document retrieval, and web search. Hence, various data structures have been proposed for improving their…

数据库 · 计算机科学 2026-04-03 Lara Kreis , Justus Henneberg , Valentin Henkys , Felix Schuhknecht , Bertil Schmidt

Tokenization sits at the boundary between high-throughput genomic input and GPU compute, posing challenges in both algorithm design and system throughput. Overlapping k-mer tokenization can introduce information leakage under masked…

基因组学 · 定量生物学 2026-01-12 Eliatan Niktab , Hardip Patel

We propose a CPU-GPU heterogeneous computing method for solving time-evolution partial differential equation problems many times with guaranteed accuracy, in short time-to-solution and low energy-to-solution. On a single-GH200 node, the…

计算工程、金融与科学 · 计算机科学 2024-10-01 Tsuyoshi Ichimura , Kohei Fujita , Muneo Hori , Lalith Maddegedara , Jack Wells , Alan Gray , Ian Karlin , John Linford

The attention layer, a core component of Transformer-based LLMs, brings out inefficiencies in current GPU systems due to its low operational intensity and the substantial memory requirements of KV caches. We propose a High-bandwidth…

硬件体系结构 · 计算机科学 2025-12-19 Myunghyun Rhee , Joonseop Sim , Taeyoung Ahn , Seungyong Lee , Daegun Yoon , Euiseok Kim , Kyoung Park , Youngpyo Joo , Hoshik Kim

We present a massively parallel Lagrange decomposition method for solving 0--1 integer linear programs occurring in structured prediction. We propose a new iterative update scheme for solving the Lagrangean dual and a perturbation technique…

最优化与控制 · 数学 2022-04-20 Ahmed Abbas , Paul Swoboda

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

定量方法 · 定量生物学 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

GPUs have been widely used to accelerate computations exhibiting simple patterns of parallelism - such as flat or two-level parallelism - and a degree of parallelism that can be statically determined based on the size of the input dataset.…

分布式、并行与集群计算 · 计算机科学 2016-11-18 Hancheng Wu , Da Li , Michela Becchi

To tackle the exponentially increasing throughput of Next-Generation Sequencing (NGS), most of the existing short-read aligners can be configured to favor speed in trade of accuracy and sensitivity. SOAP3-dp, through leveraging the…

Current AI code generation systems suffer from significant latency bottlenecks due to CPU-GPU data transfers during compilation, execution, and testing phases. We establish theoretical foundations for three complementary approaches to…

分布式、并行与集群计算 · 计算机科学 2025-12-15 Adilet Metinov , Gulida M. Kudakeeva , Gulnara D. Kabaeva

Massive off-chip accesses in GPUs are the main performance bottleneck, and we divided these accesses into three types: (1) Write, (2) Data-Read, and (3) Read-Only. Besides, We find that many writes are duplicate, and the duplication can be…

硬件体系结构 · 计算机科学 2024-08-20 Wei Zhao , Dan Feng , Wei Tong , Xueliang Wei , Bing Wu

This paper introduces cuHALLaR, a GPU-accelerated implementation of the HALLaR method proposed in Monteiro et al. 2024 for solving large-scale semidefinite programming (SDP) problems. We demonstrate how our Julia-based implementation…

Accelerating the deep learning inference is very important for real-time applications. In this paper, we propose a novel method to fuse the layers of convolutional neural networks (CNNs) on Graphics Processing Units (GPUs), which applies…

分布式、并行与集群计算 · 计算机科学 2020-07-30 Xueying Wang , Guangli Li , Xiao Dong , Jiansong Li , Lei Liu , Xiaobing Feng

General Purpose computing on Graphical Processing Units (GPGPU) has resulted in unprecedented levels of speedup over its CPU counterparts, allowing programmers to harness the computational power of GPU shader cores to accelerate other…

分布式、并行与集群计算 · 计算机科学 2023-03-20 Vani Nagarajan , Milind Kulkarni

This paper proposes a GPU-accelerated optimization framework for collision avoidance problems where the controlled objects and the obstacles can be modeled as the finite union of convex polyhedra. A novel collision avoidance constraint is…

机器人学 · 计算机科学 2024-06-12 Zeming Wu , Zhuping Wang , Hao Zhang

We present a multi-purpose genetic algorithm, designed and implemented with GPGPU / CUDA parallel computing technology. The model was derived from a multi-core CPU serial implementation, named GAME, already scientifically successfully…

天体物理仪器与方法 · 物理学 2015-01-30 Stefano Cavuoti , Mauro Garofalo , Massimo Brescia , Antonio Pescapé , Giuseppe Longo , Giorgio Ventre