相关论文: Time-resolved and spectral-resolved optical imagin…

In nature, animals encounter high dimensional sensory stimuli that have complex statistical and dynamical structure. Attempts to study the neural coding of these natural signals face challenges both in the selection of the signal ensemble…

Multispectral photoacoustic (PA) imaging is a prime modality to monitor hemodynamics and changes in blood oxygenation (sO2). Although sO2 changes can be an indicator of brain activity both in normal and in pathological conditions, PA…

Behavioral sequences of animals are often structured and can be described by probabilistic rules (or "action syntax"). The patterns of vocal elements in birdsong are a prime example. The encoding of such rules in neural circuits is poorly…

Objective: The surgical resection of brain areas with high rates of visually identified high frequency oscillations (HFOs) on EEG has been correlated with improved seizure control. However, it can be difficult to distinguish normal from…

Non-invasive observation of spatiotemporal neural activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience. We developed a real-time volumetric and multispectral optoacoustic tomography…

Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is associated with the onset of tachycardia upon postural change. The current diagnosis involves the measurement of heart rate (HR) and blood pressure (BP) during head-up tilt…

Advances in passive acoustic monitoring and machine learning have led to the procurement of vast datasets for computational bioacoustic research. Nevertheless, data scarcity is still an issue for rare and underrepresented species. This…

Studies of motor control have almost universally examined firing rates to investigate how the brain shapes behavior. In principle, however, neurons could encode information through the precise temporal patterning of their spike trains as…

Many current paradigms for acoustic event detection (AED) are not adapted to the organic variability of natural sounds, and/or they assume a limit on the number of simultaneous sources: often only one source, or one source of each type, may…

The problem of deciphering how low-level patterns (action potentials in the brain, amino acids in a protein, etc.) drive high-level biological features (sensorimotor behavior, enzymatic function) represents the central challenge of…

Spectroscopic photoacoustic (sPA) imaging can potentially estimate blood oxygenation saturation (sO2) in vivo noninvasively. However, quantitatively accurate results require accurate optical fluence estimates. Robust modeling in…

Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While…

Anemia is a global health concern, prompting the need for rapid and accurate diagnostic tools, especially for vulnerable populations. Estimating the blood lysis level (LL) and oxygen saturation (SO2) are essential not only for anemia but…

Practice of a complex motor gesture involves exploration of motor space to attain a better match to target output, but little is known about the neural code for such exploration. Here, we examine spiking in an area of the songbird brain…

Central CO2chemosensitivity is crucial for all air-breathing vertebrates and raises the question of itsrole in ventilatory rhythmogenesis. In this study, neurograms of ventilatory motor outputs recorded infacial nerve of premetamorphic and…

Photoplethysmography (PPG) is a common tool for monitoring cardiopulmonary health. Relying on absorption or reflectance of light by hemoglobin in the blood, the measured PPG waveform can be analyzed per heart beat using physiological…

Multispectral Optoacoustic Tomography (MSOT) uniquely enables spatial mapping in high resolution of oxygen saturation (SO$_2$), with potential applications in studying pathological complications and therapy efficacy. MSOT offers seamless…

Zebra finch are a model animal used in the study of audition. They are adept at recognizing zebra finch songs and the neural pathway involved in song recognition is well studied. Here, this example is used to illustrate the estimation of…

In many clinical conditions, such as head trauma, stroke, and low cardiac output states, the brain is at risk for hypoxic-ischemic injury. The metabolic rate and oxygen consumption of the brain are reflected in internal jugular venous…

Evolution has shaped animal bodies, yet to what extent biomechanical systems impose constraints and provide opportunities across different behaviors remains unclear. In birds, quiet breathing operates at a resonance of the respiratory…