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Molecular motors transport various cargos along cytoskeletal filaments, analogous to trucks on roads. In contrast to vehicles, however, molecular motors do not work alone but in small teams. We describe a simple model for the transport of a…

统计力学 · 物理学 2008-07-08 Melanie J. I. Müller , Janina Beeg , Rumiana Dimova , Stefan Klumpp , Reinhard Lipowsky

As engineering advances toward the nanoscale, understanding design principles for molecular motors becomes increasingly valuable. Many molecular motors consist of coupled components transducing one free-energy source into another. Here, we…

统计力学 · 物理学 2026-02-09 Sara Iranbakhsh , David A. Sivak

Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-force' approximation for the effect of cargo on motor…

统计力学 · 物理学 2023-04-11 Aidan I Brown , David A Sivak

The motion of an artificial micro-scale swimmer that uses a chemical reaction catalyzed on its own surface to achieve autonomous propulsion is fully characterized experimentally. It is shown that at short times, it has a substantial…

Biological motors are marvels of nature that inspire creation of their synthetic counterparts with comparable nanoscale dimensions, high efficiency and diverse functions. Molecular motors have been synthesized, but obtaining nanomotors…

软凝聚态物质 · 物理学 2020-04-09 Ye Yuan , Ghaneema N. Abuhaimed , Qingkun Liu , Ivan I. Smalyukh

A current-carrying resonant nanoscale device, simulated by non-adiabatic molecular dynamics, exhibits sharp activation of non-conservative current-induced forces with bias. The result, above the critical bias, is generalized rotational…

介观与纳米尺度物理 · 物理学 2012-09-21 Daniel Dundas , Brian Cunningham , Claire Buchanan , Asako Terasawa , Anthony T. Paxton , Tchavdar N. Todorov

Synthetic nanomotors powered by chemical reactions have been designed to act as vehicles for active cargo transport, drug delivery as well as a variety of other uses. Collections of such motors, acting in consort, can self-assemble to form…

软凝聚态物质 · 物理学 2024-03-05 Narender Khatri , Raymond Kapral

The fabrication of synthetic self-propelled particles and the experimental investigations of their dynamics have stimulated interest in self-generated phoretic effects that propel nano- and micron-scale objects. Theoretical modeling of…

软凝聚态物质 · 物理学 2014-10-10 Pierre de Buyl , Raymond Kapral

Simulations can help unravel the complicated ways in which molecular structure determines function. Here, we use molecular simulations to show how slight alterations of a molecular motor's structure can cause the motor's typical dynamical…

统计力学 · 物理学 2023-08-21 Alex Albaugh , Geyao Gu , Todd R. Gingrich

The movement of motor particles consisting of one or several molecular motors bound to a cargo particle is studied theoretically. The particles move on patterns of immobilized filaments. Several patterns are described for which the motor…

统计力学 · 物理学 2009-11-11 Stefan Klumpp , Reinhard Lipowsky

We study a model of synthetic molecular motor - a [3]-catenane consisting of two small macrocycles mechanically interlocked with a bigger one - subjected to a time-dependent driving using stochastic thermodynamics. The model presents…

统计力学 · 物理学 2023-06-28 Massimo Bilancioni , Massimiliano Esposito , Emanuele Penocchio

Micron-sized self-propelled (active) particles can be considered as model systems for characterizing more complex biological organisms like swimming bacteria or motile cells. We produce asymmetric microswimmers by soft lithography and study…

Processive molecular motors which drive the traffic of organelles in cells move in a directed way along cytoskeletal filaments. On large time scales, they perform motor walks, i.e., peculiar random walks which arise from the repeated…

统计力学 · 物理学 2007-05-23 Stefan Klumpp , Theo M. Nieuwenhuizen , Reinhard Lipowsky

A molecular motor is made of either a single macromolecule or a macromolecular complex. Just like their macroscopic counterparts, molecular motors "transduce" input energy into mechanical work. All the nano-motors considered here operate…

生物物理 · 物理学 2013-07-18 Debashish Chowdhury

Several designs for micro-devices for chemotaxis based on nano-motors are proposed. The nano- or micro-motors are the conventional Janus rods or spheres that are powered by the catalytic reaction of fuels such as hydrogen peroxide. It is…

软凝聚态物质 · 物理学 2012-09-10 Phil Attard

In addition to self-propulsion by phoretic mechanisms that arises from an asymmetric distribution of reactive species around a catalytic motor, spherical particles with a uniform distribution of catalytic activity may also propel themselves…

统计力学 · 物理学 2014-01-08 Pierre de Buyl , Alexander S. Mikhailov , Raymond Kapral

Very small synthetic motors that make use of chemical reactions to propel themselves in solution hold promise for new applications in the development of new materials, science and medicine. The prospect of such potential applications, along…

软凝聚态物质 · 物理学 2016-05-17 Mu-Jie Huang , Jeremy Schofield , Raymond Kapral

Motor enzymes catalyze chemical reactions, like the hydrolysis of ATP, and in the process they also perform work. Recent studies indicate that motor enzymes perform work with specific intermediate steps in their catalyzed reactions,…

生物物理 · 物理学 2007-05-23 Josh E. Baker

Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state ``burnt-bridge'' models.…

软凝聚态物质 · 物理学 2009-11-13 Max N. Artyomov , Alexander Yu. Morozov , Anatoly B. Kolomeisky

We analyze a simple stochastic model to describe motor molecules which cooperate in large groups and present a physical mechanism which can lead to oscillatory motion if the motors are elastically coupled to their environment. Beyond a…

软凝聚态物质 · 物理学 2009-10-28 Frank Julicher , Jacques Prost