相关论文: Bayesian data augmentation dose finding with conti…

An important objective in biomedical risk assessment is estimation of minimum exposure levels that induce a pre-specified adverse response in a target population. The exposure/dose points in such settings are known as Benchmark Doses…

Analysis of lifetime data from epidemiological studies or destructive testing often involves current status censoring, wherein individuals are examined only once and their event status is recorded only at that specific time point. In…

Missing values exist in nearly all clinical studies because data for a variable or question are not collected or not available. Inadequate handling of missing values can lead to biased results and loss of statistical power in analysis.…

Current data augmentation techniques and transformations are well suited for improving the size and quality of natural image datasets but are not yet optimized for medical imaging. We hypothesize that sub-optimal data augmentations can…

Model-assisted interval designs such as the Keyboard design are transparent and easy to implement in phase I oncology trials. However, interim decisions based solely on data from the current dose may overlook informative signals from…

Model-assisted designs have garnered significant attention in recent years due to their high accuracy in identifying the maximum tolerated dose (MTD) and their operational simplicity. To identify the MTD, they employ estimated dose limiting…

Advances in data collecting technologies in genomics have significantly increased the need for tools designed to study the genetic basis of many diseases. Effective statistical methods should excel in both prediction accuracy and biomarker…

Up-and-Down (U&D) is a popular sequential design for estimating threshold percentiles in binary experiments. However, U&D application practices have stagnated, and significant gaps in understanding its properties persist. The first part of…

Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly hard in an…

Accurate trend forecasting in healthcare time series is essential for planning and resource allocation. This paper proposes a Bayesian framework for predicting oncology demand trends, modeling weekly appointments as a Poisson process with a…

Data Augmentation (DA) -- enriching training data by adding synthetic samples -- is a technique widely adopted in Computer Vision (CV) and Natural Language Processing (NLP) tasks to improve models performance. Yet, DA has struggled to gain…

Combination of several anti-cancer treatments has typically been presumed to have enhanced drug activity. Motivated by a real clinical trial, this paper considers phase I-II dose finding designs for dual-agent combinations, where one main…

Data augmentation is essential when applying Machine Learning in small-data regimes. It generates new samples following the observed data distribution while increasing their diversity and variability to help researchers and practitioners…

Most conventional risk analysis methods rely on a single best estimate of exposure per person which does not allow for adjustment for exposure-related uncertainty. Here, we propose a Bayesian model averaging method to properly quantify the…

Given the joint chances of a pair of random variables one can compute quantities of interest, like the mutual information. The Bayesian treatment of unknown chances involves computing, from a second order prior distribution and the data…

An accurate estimation of the dose-response relationship is important to determine the optimal dose. For this purpose, a dose finding trial in which subjects are randomized to a few fixed dose levels is the most commonly used design. Often,…

Clinical decision support using data mining techniques offers more intelligent way to reduce the decision error in the last few years. However, clinical datasets often suffer from high missingness, which adversely impacts the quality of…

We present a novel data augmentation method to address the challenge of data scarcity in modeling longitudinal patterns in Electronic Health Records (EHR) of patients using natural language processing (NLP) algorithms. The proposed method…

Existing automatic data augmentation (DA) methods either ignore updating DA's parameters according to the target model's state during training or adopt update strategies that are not effective enough. In this work, we design a novel data…

Deep learning has performed remarkably well on many tasks recently. However, the superior performance of deep models relies heavily on the availability of a large number of training data, which limits the wide adaptation of deep models on…