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This paper addresses the challenge of a particular class of noisy state observations in Markov Decision Processes (MDPs), a common issue in various real-world applications. We focus on modeling this uncertainty through a confusion matrix…

机器学习 · 计算机科学 2023-12-15 Amirhossein Afsharrad , Sanjay Lall

This paper explores fluctuations and noise in various facets of cancer development. The three areas of particular focus are the stochastic progression of cells to cancer, fluctuations of the tumor size during treatment, and noise in cancer…

细胞行为 · 定量生物学 2009-11-10 Matthew J. Berryman , Sabrina L. Spencer , Andrew Allison , Derek Abbott

We study detection of random signals corrupted by noise that over time switch their values (states) from a finite set of possible values, where the switchings occur at unknown points in time. We model such signals by means of a random…

信息论 · 计算机科学 2017-12-27 Dragana Bajović , Kanghang He , Lina Stanković , Dejan Vukobratović , Vladimir Stanković

Markovian population models are suitable abstractions to describe well-mixed interacting particle systems in situation where stochastic fluctuations are significant due to the involvement of low copy particles. In molecular biology,…

定量方法 · 定量生物学 2014-01-17 Christoph Zechner , Federico Wadehn , Heinz Koeppl

Measurements are a vital part of any quantum computation, whether as a final step to retrieve results, as an intermediate step to inform subsequent operations, or as part of the computation itself (as in measurement-based quantum…

量子物理 · 物理学 2023-04-14 Stefanie J. Beale , Joel J. Wallman

We consider the problem of signal estimation (denoising) from a statistical mechanical perspective, using a relationship between the minimum mean square error (MMSE), of estimating a signal, and the mutual information between this signal…

信息论 · 计算机科学 2016-11-17 Neri Merhav , Dongning Guo , Shlomo Shamai

Controllers for autonomous systems that operate in safety-critical settings must account for stochastic disturbances. Such disturbances are often modelled as process noise, and common assumptions are that the underlying distributions are…

系统与控制 · 电气工程与系统科学 2022-12-08 Thom S. Badings , Alessandro Abate , Nils Jansen , David Parker , Hasan A. Poonawala , Marielle Stoelinga

Direct simulation of biomolecular dynamics in thermal equilibrium is challenging due to the metastable nature of conformation dynamics and the computational cost of molecular dynamics. Biased or enhanced sampling methods may improve the…

化学物理 · 物理学 2015-06-12 Benjamin Trendelkamp-Schroer , Frank Noe

Tensor models play an increasingly prominent role in many fields, notably in machine learning. In several applications, such as community detection, topic modeling and Gaussian mixture learning, one must estimate a low-rank signal from a…

机器学习 · 统计学 2022-06-16 José Henrique de Morais Goulart , Romain Couillet , Pierre Comon

Resistive Pulse Sensing (RPS) is a key label-free technology to measure particles and single-cell size distribution. As a growing corpus of evidence supports that cancer cells exhibit distinct mechanical phenotypes from healthy cells,…

生物物理 · 物理学 2020-04-01 Antoine Riaud , Anh L. P. Thai , Wei Wang , Valerie Taly

In this article, we will see a new approach to study the impact of a small microscopic population of cancer cells on a macroscopic population of healthy cells, with an example inspired by pathological hematopoiesis. Hematopoiesis is the…

概率论 · 数学 2023-03-14 Céline Bonnet

A novel strategy that combines a given collection of $\pi$-reversible Markov kernels is proposed. At each Markov transition, one of the available kernels is selected via a state-dependent probability distribution. In contrast to random-scan…

统计方法学 · 统计学 2022-03-30 Florian Maire , Pierre Vandekerkhove

We use a stochastic birth-death model for a population of cells to estimate the normal tissue complication probability (NTCP) under a particular radiotherapy protocol. We specifically allow for interaction between cells, via a nonlinear…

种群与进化 · 定量生物学 2018-03-26 Peter G. Hufton , Elizabeth Buckingham-Jeffery , Tobias Galla

In a previous work, we presented a model that integrates cancer cell differentiation and immunotherapy, analysing a particular therapy against cancer stem cells by cytotoxic cell vaccines. As every biological system is exposed to random…

生物物理 · 物理学 2022-12-14 Marcela Reale , David Margarit , Ariel Scagliotti , Lilia Romanelli

We propose a simple model for sample space reducing (SSR) stochastic process, where the dynamical variable denoting the size of the state space is continuous. In general, one can view the model as a multiplicative stochastic process, with a…

统计力学 · 物理学 2025-07-25 Rahul Chhimpa , Avinash Chand Yadav\

A networked system often uses a shared communication network to transmit the measurements to a remotely located estimation center. Due to the limited bandwidth of the channel, a delay may appear while receiving the measurements. This delay…

信号处理 · 电气工程与系统科学 2023-04-05 Ranjeet Kumar Tiwari , Shovan Bhaumik

We establish the convergence rates and asymptotic distributions of the common break change-point estimators, obtained by least squares and maximum likelihood in panel data models and compare their asymptotic variances. Our model assumptions…

统计理论 · 数学 2017-08-22 Monika Bhattacharjee , Moulinath Banerjee , George Michailidis

In compressed sensing one measures sparse signals directly in a compressed form via a linear transform and then reconstructs the original signal. However, it is often the case that the linear transform itself is known only approximately, a…

信息论 · 计算机科学 2013-11-13 Florent Krzakala , Marc Mézard , Lenka Zdeborová

This paper addresses the detection of a stochastic process in noise from irregular samples. We consider two hypotheses. The \emph{noise only} hypothesis amounts to model the observations as a sample of a i.i.d. Gaussian random variables…

信息论 · 计算机科学 2009-09-25 Walid Hachem , Eric Moulines , Francois Roueff

The recently proposed statistical finite element (statFEM) approach synthesises measurement data with finite element models and allows for making predictions about the unknown true system response. We provide a probabilistic error analysis…

统计理论 · 数学 2025-06-17 Toni Karvonen , Fehmi Cirak , Mark Girolami
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