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In living cells, cycles of formation and dissolution of liquid droplets can mediate biological functions such as DNA repair. However, the minimal physicochemical prerequisite for such droplet oscillations remains elusive. Here, we present a…

软凝聚态物质 · 物理学 2025-03-17 Ivar S. Haugerud , Hidde D. Vuijk , Job Boekhoven , Christoph A. Weber

Building on the striking similarity between the structure of the spindle during mitosis in living cells and nematic textures in confined liquid crystals, we use a continuum model of two-dimensional nematic liquid crystal droplets, to…

软凝聚态物质 · 物理学 2017-02-24 Marco Leoni , Oksana V. Manyuhina , Mark J. Bowick , M. Cristina Marchetti

Recent experiments and numerical studies have drawn attention to the dynamics of active nematics. Two-dimensional active nematics flow spontaneously and exhibit spatiotemporal chaotic flows with proliferation of topological defects in the…

软凝聚态物质 · 物理学 2020-07-08 Farzan Vafa , Mark J. Bowick , M. Cristina Marchetti , Boris I. Shraiman

The spontaneous emergence of collective flows is a generic property of active fluids and often leads to chaotic flow patterns characterised by swirls, jets, and topological disclinations in their orientation field. However, the ability to…

软凝聚态物质 · 物理学 2017-03-07 Tyler N. Shendruk , Amin Doostmohammadi , Kristian Thijssen , Julia M. Yeomans

The translation and shape deformations of a passive viscous Newtonian droplet immersed in an active nematic liquid crystal under circular confinement are analyzed using a linear stability analysis. We focus on the case of a sharply aligned…

软凝聚态物质 · 物理学 2025-07-29 Tanumoy Dhar , Michael J. Shelley , David Saintillan

Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

生物物理 · 物理学 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg

With exquisite precision and reproducibility, cells orchestrate the cooperative action of thousands of nanometer-sized molecular motors to carry out mechanical tasks at much larger length scales, such as cell motility, division and…

软凝聚态物质 · 物理学 2013-01-08 Tim Sanchez , Daniel T. N. Chen , Stephen J. DeCamp , Michael Heymann , Zvonimir Dogic

We present a continuum level analytical model of a droplet of active contractile fluid consisting of filaments and motors. We calculate the steady state flows that result from a splayed polarisation of the filaments. We account for the…

细胞行为 · 定量生物学 2014-02-20 Carl A. Whitfield , Davide Marenduzzo , Raphaël Voituriez , Rhoda J. Hawkins

We study theoretically the hydrodynamics of a fluid drop containing oriented filaments endowed with active contractile or extensile stresses and placed on a solid surface. The active stresses alter qualitatively the wetting properties of…

软凝聚态物质 · 物理学 2015-06-03 Jean-Francois Joanny , Sriram Ramaswamy

Microscopic active droplets are able to swim autonomously in viscous flows: this puzzling feature stems from solute exchanges with the surrounding fluid via surface reactions or their spontaneous solubilisation, and the interfacial flows…

流体动力学 · 物理学 2022-12-01 Sebastien Michelin

We develop a formal analogy between configurational stresses in two distinct physical systems, and study the flows that they induce when the configurations of interest include topological de- fects. The two systems in question are…

软凝聚态物质 · 物理学 2018-03-23 Christopher Conklin , Jorge Vinals , Oriol T. Valls

Chemically active droplets provide simple models for cell-like systems that can grow and divide. Such active droplet systems are driven away from thermodynamic equilibrium and turn over chemically, which corresponds to a simple metabolism.…

生物物理 · 物理学 2022-09-28 Jonathan Bauermann , Christoph A. Weber , Frank Jülicher

In the last years self-motile droplets attracted the attention of scientists from different fields ranging from applied biology to theoretical physics, because of their promising technological applications and important biological…

软凝聚态物质 · 物理学 2023-03-31 L. N. Carenza , G. Gonnella , G. Negro

We numerically study the dynamics of a passive fluid droplet confined within a microchannel whose walls are covered with a thin layer of active gel. The latter represents a fluid of extensile material modelling, for example, a suspension of…

软凝聚态物质 · 物理学 2023-08-10 A. Tiribocchi , M. Durve , M. Lauricella , A. Montessori , S. Succi

We extend the continuum theories of active nematohydrodynamics to model a two-fluid mixture with separate velocity fields for each fluid component, coupled through a viscous drag. The model is used to study an active nematic fluid, mixed…

软凝聚态物质 · 物理学 2023-08-02 Saraswat Bhattacharyya , Julia M. Yeomans

We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we…

软凝聚态物质 · 物理学 2015-08-07 Amin Doostmohammadi , Sumesh P. Thampi , Thuan B. Saw , Chwee T. Lim , Benoit Ladoux , Julia M. Yeomans

Active emulsions and liquid crystalline shells are intriguing and experimentally realisable types of topological matter. Here we numerically study the morphology and spatiotemporal dynamics of a double emulsion, where one or two passive…

Topological defects are distinctive signatures of liquid crystals. They profoundly affect the viscoelastic behavior of the fluid by constraining the orientational structure in a way that inevitably requires global changes not achievable…

软凝聚态物质 · 物理学 2015-06-19 Luca Giomi , Mark J. Bowick , Prashant Mishra , Rastko Sknepnek , M. Cristina Marchetti

Continuum models of active nematic gels have proved successful to describe a number of biological systems consisting of a population of rodlike motile subunits in a fluid environment. However, in order to get a thorough understanding of the…

软凝聚态物质 · 物理学 2023-05-03 Stefano Turzi

Controlling fluidic flows in active droplets is crucial in developing intelligent models to understand and mimic single-celled microorganisms. Typically, these fluidic flows are affected by the interfacial dynamics of chemical agents. We…

软凝聚态物质 · 物理学 2024-05-10 Muhammad Turab Ali Khan , Gaurav Gardi , Ren Hao Soon , Mingchao Zhang , Metin Sitti