相关论文: Initiation and blocking of the action potential in…
We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…
It is suggested that the propagation of the action potential is accompanied by an axoplasmic pressure pulse propagating in the axoplasm along the axon length. The pressure pulse stretch-modulates voltage-gated Na (Nav) channels embedded in…
We propose a non-thermal mechanism of weak microwave field impact on a nerve fiber. It is shown that in the range of about 30 - 300 GHz there are strongly pronounced resonances associated with the excitation of ultrasonic vibrations in the…
We show that the action potential signals generated inside axons are reaction-diffusion solitons or reaction-diffusion waves, refuting the Hodgkin and Huxley hypothesis that action potentials propagate along axons with an elastic wave…
Axons transmit action potentials with high fidelity and minimal jitter. This unique capability is likely the result of the spatiotemporal arrangement of sodium channels along the axon. Super-resolution microscopy recently revealed that the…
We introduce a method for computing probabilities for spontaneous activity and propagation fail- ure of the action potential in spatially extended, conductance-based neuronal models subject to channel noise, based on statistical properties…
Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the…
This paper presents a short selective review of the non-thermal weak microwave field impact on a nerve fiber. The published results of recent experiments are reviewed and analyzed. The theory of the authors is presented, according to which…
This work proposes a two-dimensional electrophysiological model for describing neuronal responses to external electric stimuli under patch-clamped conditions. Our proposed model successfully captures the key features of the Hodgkin-Huxley…
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic…
We demonstrate that our recently developed theory of electric field wave propagation in anisotropic and inhomogeneous brain tissues, which has been shown to explain a broad range of observed coherent synchronous brain electrical processes,…
In this work we have theoretically investigated how the action potential generation and its associated intrinsic properties are affected in presence of ion channel blockers by adapting Gillepie's stochastic simulation technique on a very…
Noisy saltatory spike propagation along myelinated axons is studied within a stochastic Hodgkin-Huxley model. The intrinsic noise (whose strength is inverse proportional to the nodal membrane size) arising from fluctuations of the number of…
Classical models for predicting current flow in excitable cells such as axons, originally proposed by Hodgkin and Huxley, rely on empirical voltage-gating parameters that quantify ion transport across sodium and potassium ion channels. We…
The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory.…
Here a viable and never before investigated mechanism of propagation of spikes along neurons is proposed. In the following, velocity of propagation of small-amplitude pressure waves through the cytoplasmic interior of myelinated and…
We consider noise-assisted spike propagation in myelinated axons within a multi-compartment stochastic Hodgkin-Huxley model. The noise originates from a finite number of ion channels in each node of Ranvier. For the subthreshold internodal…
Viscous dissipation, as a small perturbative effect about the Bondi flow, shrinks its sonic sphere. An Eulerian perturbation on the steady flow gives a wave equation and the corresponding dispersion relation. The perturbation is a…
The mechanisms underlying how activity in the visual pathway may give rise through neural plasticity to many of the features observed experimentally in the early stages of visual processing was provided by Linkser in a seminal, three-paper…
By extending the crude Goldman-Hodgkin-Katz electrodiffusion model for resting-state membrane potentials in perfused giant axons of squid, we reformulate the Hodgkin-Huxley (HH) phenomenological quantitative model to create a new model…