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Next-generation sequencing technologies now constitute a method of choice to measure gene expression. Data to analyze are read counts, commonly modeled using Negative Binomial distributions. A relevant issue associated with this…

统计方法学 · 统计学 2014-11-10 Elisabetta Bonafede , Franck Picard , Stéphane Robin , Cinzia Viroli

Multi-omic datasets offer opportunities for improved biomarker discovery in cancer research, but their high dimensionality and limited sample sizes make identifying compact and effective biomarker panels challenging. Feature selection in…

基因组学 · 定量生物学 2026-04-02 Luca Cattelani , Vittorio Fortino

Multi-objective evolutionary algorithms (MOEAs) have become essential tools for solving multi-objective optimization problems (MOPs), making their running time analysis crucial for assessing algorithmic efficiency and guiding practical…

神经与进化计算 · 计算机科学 2025-07-04 Han Huang , Tianyu Wang , Chaoda Peng , Tongli He , Zhifeng Hao

Real-world optimization problems often involve stochastic and dynamic components. Evolutionary algorithms are particularly effective in these scenarios, as they can easily adapt to uncertain and changing environments but often uncertainty…

神经与进化计算 · 计算机科学 2024-04-10 Ishara Hewa Pathiranage , Frank Neumann , Denis Antipov , Aneta Neumann

Software quality estimation is a challenging and time-consuming activity, and models are crucial to face the complexity of such activity on modern software applications. In this context, software refactoring is a crucial activity within…

软件工程 · 计算机科学 2024-01-31 Vittorio Cortellessa , Daniele Di Pompeo , Vincenzo Stoico , Michele Tucci

Chance constrained optimization problems allow to model problems where constraints involving stochastic components should only be violated with a small probability. Evolutionary algorithms have been applied to this scenario and shown to…

神经与进化计算 · 计算机科学 2024-08-23 Frank Neumann , Carsten Witt

Efficiency of an optimization process is largely determined by the search algorithm and its fundamental characteristics. In a given optimization, a single type of algorithm is used in most applications. In this paper, we will investigate…

最优化与控制 · 数学 2012-03-30 Xin-She Yang , Suash Deb

Evolutionary Computation algorithms have been used to solve optimization problems in relation with architectural, hyper-parameter or training configuration, forging the field known today as Neural Architecture Search. These algorithms have…

神经与进化计算 · 计算机科学 2024-02-06 Javier Poyatos , Daniel Molina , Aitor Martínez , Javier Del Ser , Francisco Herrera

Many real-world applications require decision-makers to assess the quality of solutions while considering multiple conflicting objectives. Obtaining good approximation sets for highly constrained many-objective problems is often a difficult…

Dynamic multiobjective optimization problems (DMOPs) feature time-varying objectives, which cause the Pareto optimal solution (POS) set to drift over time and make it difficult to maintain both convergence and diversity under limited…

神经与进化计算 · 计算机科学 2026-03-31 Jian Guan , Huolong Wu , Zhenzhong Wang , Gary G. Yen , Min Jiang

We propose the cone epsilon-dominance approach to improve convergence and diversity in multiobjective evolutionary algorithms (MOEAs). A cone-eps-MOEA is presented and compared with MOEAs based on the standard Pareto relation (NSGA-II,…

神经与进化计算 · 计算机科学 2020-08-11 Lucas S. Batista , Felipe Campelo , Frederico G. Guimarães , Jaime A. Ramírez

The research community continues to seek increasingly more advanced synthetic data generators to reliably evaluate the strengths and limitations of machine learning methods. This work aims to increase the availability of datasets…

机器学习 · 计算机科学 2026-01-30 Joanna Komorniczak

Molecular docking is an essential tool for drug design. It helps the scientist to rapidly know if two molecules, respectively called ligand and receptor, can be combined together to obtain a stable complex. We propose a new multi-objective…

定量方法 · 定量生物学 2008-11-05 Jean-Charles Boisson , Laetitia Jourdan , El-Ghazali Talbi , Dragos Horvath

In multi-objective optimization problems, there might exist hidden objectives that are important to the decision-maker but are not being optimized. On the other hand, there might also exist irrelevant objectives that are being optimized but…

最优化与控制 · 数学 2022-06-06 Seyed Mahdi Shavarani , Manuel López-Ibáñez , Richard Allmendinger

Site-specific weather forecasts are essential to accurate prediction of power demand and are consequently of great interest to energy operators. However, weather forecasts from current numerical weather prediction (NWP) models lack the…

大气与海洋物理 · 物理学 2024-08-02 MengMeng Han , Tennessee Leeuwenburg , Brad Murphy

Food production is a complex process which can benefit from many optimisation approaches. However, there is growing interest in methods that support customisation of food properties to satisfy individual consumer preferences. This paper…

神经与进化计算 · 计算机科学 2022-04-14 Mohammad Majid al-Rifaie , Marc Cavazza

This paper concerns the modeling and numerical simulation of the process of speciation. In particular, given conditions for which one or more speciation events within an ecosystem occur, our aim is to develop the necessary modeling and…

种群与进化 · 定量生物学 2021-10-08 Mats K. Brun , Elyes Ahmed , Jan Martin Nordbotten , Nils Christian Stenseth

The incentive for using Evolutionary Algorithms (EAs) for the automated optimization and training of deep neural networks (DNNs), a process referred to as neuroevolution, has gained momentum in recent years. The configuration and training…

神经与进化计算 · 计算机科学 2022-05-09 Fergal Stapleton , Edgar Galván , Ganesh Sistu , Senthil Yogamani

Data-driven evolutionary multi-objective optimization (EMO) has been recognized as an effective approach for multi-objective optimization problems with expensive objective functions. The current research is mainly developed for problems…

神经与进化计算 · 计算机科学 2022-05-31 Renzhi Chen , Ke Li

As evolutionary algorithms (EAs) are general-purpose optimization algorithms, recent theoretical studies have tried to analyze their performance for solving general problem classes, with the goal of providing a general theoretical…

神经与进化计算 · 计算机科学 2022-11-29 Chao Qian