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We present a numerical algorithm that allows the approximation of optimal controls for stochastic reaction-diffusion equations with additive noise by first reducing the problem to controls of feedback form and then approximating the…

最优化与控制 · 数学 2023-09-15 Wilhelm Stannat , Alexander Vogler , Lukas Wessels

Optimal designs minimize the number of experimental runs (samples) needed to accurately estimate model parameters, resulting in algorithms that, for instance, efficiently minimize parameter estimate variance. Governed by knowledge of past…

统计方法学 · 统计学 2023-02-03 Nicholas W. Barendregt , Emily G. Webb , Zachary P. Kilpatrick

Stochastic reaction network models are often used to explain and predict the dynamics of gene regulation in single cells. These models usually involve several parameters, such as the kinetic rates of chemical reactions, that are not…

统计计算 · 统计学 2020-01-07 Thomas A. Catanach , Huy D. Vo , Brian Munsky

Motivated by reduction of computational complexity, this work develops sign-error adaptive filtering algorithms for estimating time-varying system parameters. Different from the previous work on sign-error algorithms, the parameters are…

最优化与控制 · 数学 2016-11-17 Araz Hashemi , G. Yin , Le Yi Wang

Markov decision processes (MDPs) are known to be sensitive to parameter specification. Distributionally robust MDPs alleviate this issue by allowing for \emph{ambiguity sets} which give a set of possible distributions over parameter sets.…

最优化与控制 · 数学 2021-05-05 Julien Grand-Clément , Christian Kroer

Stochastic Chemical Reaction Networks are continuous time Markov chain models that describe the time evolution of the molecular counts of species interacting stochastically via discrete reactions. Such models are ubiquitous in systems and…

定量方法 · 定量生物学 2024-02-01 Theodore W. Grunberg , Domitilla Del Vecchio

Estimating parameters of a diffusion process given continuous-time observations of the process via maximum likelihood approaches or, online, via stochastic gradient descent or Kalman filter formulations constitutes a well-established…

统计方法学 · 统计学 2025-03-17 Jan Albrecht , Sebastian Reich

We develop new unbiased estimators of a number of quantities defined for functions of conditional moments, like conditional expectations and variances, of functions of two independent random variables given the first variable, including…

统计计算 · 统计学 2013-10-03 Tomasz Badowski

Stochastic reaction network models arise in intracellular chemical reactions, epidemiological models and other population process models, and are a class of continuous time Markov chains which have the nonnegative integer lattice as state…

数值分析 · 数学 2024-07-26 Muruhan Rathinam , Mingkai Yu

Differential network is an important tool to capture the changes of conditional correlations under two sample cases. In this paper, we introduce a fast iterative algorithm to recover the differential network for high-dimensional data. The…

统计计算 · 统计学 2019-01-23 Zhou Tang , Zhangsheng Yu , Cheng Wang

We develop a hierarchical functional derivative method to investigate the reduced dynamics of a quantum dissipative system within the framework of a stochastic decoupling description. Keeping only the lowest order truncation of the…

量子物理 · 物理学 2018-09-26 Wei Wu

We propose a method to approximate continuous-time, continuous-state stochastic processes by a discrete-time Markov chain defined on a nonuniform grid. Our method provides exact moment matching for processes whose first and second moments…

概率论 · 数学 2025-11-27 Do Hyun Kim , Ahmet Cetinkaya

In this work we derive a second-order approach to bilevel optimization, a type of mathematical programming in which the solution to a parameterized optimization problem (the "lower" problem) is itself to be optimized (in the "upper"…

最优化与控制 · 数学 2022-05-06 Robert Dyro , Edward Schmerling , Nikos Arechiga , Marco Pavone

There exist several methods for simulating biological and physical systems as represented by chemical reaction networks. Systems with low numbers of particles are frequently modelled as discrete-state Markov jump processes and are typically…

定量方法 · 定量生物学 2022-10-24 Joshua C. Kynaston , Christian A Yates , Anna Hekkink , Chris Guiver

In this paper, we propose a distributed stochastic second-order proximal method that enables agents in a network to cooperatively minimize the sum of their local loss functions without any centralized coordination. The proposed algorithm,…

最优化与控制 · 数学 2022-11-22 Chenyang Qiu , Shanying Zhu , Zichong Ou , Jie Lu

Stochastic variational inference for collapsed models has recently been successfully applied to large scale topic modelling. In this paper, we propose a stochastic collapsed variational inference algorithm in the sequential data setting.…

机器学习 · 统计学 2015-12-08 Pengyu Wang , Phil Blunsom

In this paper, we investigate diagonal estimation for large or implicit matrices, aiming to develop a novel and efficient stochastic algorithm that incorporates adaptive parameter selection. We explore the influence of different eigenvalue…

机器学习 · 统计学 2024-10-16 Zongyuan Han , Wenhao Li , Shengxin Zhu

In this paper, an alternative approximation to the innovation method is introduced for the parameter estimation of diffusion processes from partial and noisy observations. This is based on a convergent approximation to the first two…

最优化与控制 · 数学 2013-12-19 J. C. Jimenez

Many real-world systems are characterized by stochastic dynamical rules where a complex network of interactions among individual elements probabilistically determines their state. Even with full knowledge of the network structure and of the…

物理与社会 · 物理学 2018-05-15 Filippo Radicchi , Claudio Castellano

We develop a systematic approach to the linear-noise approximation for stochastic reaction systems with distributed delays. Unlike most existing work our formalism does not rely on a master equation, instead it is based upon a dynamical…

统计力学 · 物理学 2013-12-13 Tobias Brett , Tobias Galla