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In adaptive radiotherapy, deformable image registration is often conducted between the planning CT and treatment CT (or cone beam CT) to generate a deformation vector field (DVF) for dose accumulation and contour propagation. The auto…

医学物理 · 物理学 2015-06-12 Xuejun Gu , Bin Dong , Jing Wang , John Yordy , Loren Mell , Xun Jia , Steve B. Jiang

Cone-beam CT (CBCT)-based online adaptive radiotherapy calls for accurate auto-segmentation to reduce the time cost for physicians to edit contours. However, deep learning (DL)-based direct segmentation of CBCT images is a challenging task,…

医学物理 · 物理学 2023-02-22 Xiao Liang , Howard Morgan , Ti Bai , Michael Dohopolski , Dan Nguyen , Steve Jiang

Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans essential. Conventional DIR methods are often too slow for…

Background and Purpose: Voxel-based analysis (VBA) helps to identify dose-sensitive regions by aligning individual dose distributions within a common coordinate system (CCS). Accurate deformable image registration (DIR) is essential for…

医学物理 · 物理学 2025-09-26 Xingyue Ruan , Xia Li , Muheng Li , Barbara Bachtiary , Antony Lomax , Zhiling Chen , Ye Zhang

The purpose of this study is to develop a deep learning based method that can automatically generate segmentations on cone-beam CT (CBCT) for head and neck online adaptive radiation therapy (ART), where expert-drawn contours in planning CT…

医学物理 · 物理学 2021-02-02 Xiao Liang , Howard Morgan , Dan Nguyen , Steve Jiang

Deformable image registration (DIR) is a crucial tool in radiotherapy for analyzing anatomical changes and motion patterns. Current DIR implementations rely on discrete volumetric motion representation, which often leads to compromised…

医学物理 · 物理学 2025-07-22 Xia Li , Runzhao Yang , Muheng Li , Xiangtai Li , Antony J. Lomax , Joachim M. Buhmann , Ye Zhang

Online adaptive radiation therapy (ART) promises the ability to deliver an optimal treatment in response to daily patient anatomic variation. A major technical barrier for the clinical implementation of online ART is the requirement of…

Purpose: Deformable image registration (DIR) is critical in adaptive radiation therapy (ART) to account for anatomical changes. Conventional intensity-based DIR methods often fail when image intensities differ. This study evaluates a hybrid…

医学物理 · 物理学 2024-11-27 Keyur D. Shah , James A. Shackleford , Nagarajan Kandasamy , Gregory C. Sharp

Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose accumulation. Approach: We evaluated DIR accuracy in 25…

Various multi-modal imaging sensors are currently involved at different steps of an interventional therapeutic work-flow. Cone beam computed tomography (CBCT), computed tomography (CT) or Magnetic Resonance (MR) images thereby provides…

图像与视频处理 · 电气工程与系统科学 2020-11-25 Luc Lafitte , Rémi Giraud , Cornel Zachiu , Mario Ries , Olivier Sutter , Antoine Petit , Olivier Seror , Clair Poignard , Baudouin Denis de Senneville

Cone-beam CT (CBCT) is installed in the treatment room to facilitate online clinical applications, including image guidance in radiation and surgery. Half-fan and short-can are the commonly used modes in clinical applications to expand the…

医学物理 · 物理学 2022-05-24 Junbo Peng

Digital Breast Tomosynthesis (DBT) provides an insight into the fine details of normal fibroglandular tissues and abnormal lesions by reconstructing a pseudo-3D image of the breast. In this respect, DBT overcomes a major limitation of…

计算机视觉与模式识别 · 计算机科学 2013-07-24 Guang Yang , John H. Hipwell , David J. Hawkes , Simon R. Arridge

Computer-Assisted Interventions enable clinicians to perform precise, minimally invasive procedures, often relying on advanced imaging methods. Cone-beam computed tomography (CBCT) can be used to facilitate computer-assisted interventions,…

图像与视频处理 · 电气工程与系统科学 2024-12-04 Maximilian E. Tschuchnig , Philipp Steininger , Michael Gadermayr

In radiation therapy (RT), the reliance on pre-treatment computed tomography (CT) images encounter challenges due to anatomical changes, necessitating adaptive planning. Daily cone-beam CT (CBCT) imaging, pivotal for therapy adjustment,…

计算机视觉与模式识别 · 计算机科学 2024-09-20 Joonil Hwang , Sangjoon Park , NaHyeon Park , Seungryong Cho , Jin Sung Kim

Cone beam computed tomography (CBCT) images can be used for dose calculation in adaptive radiation therapy (ART). The main challenges are the large artefacts and inaccurate Hounsfield unit (HU) values. Currently, deformed planning CT images…

医学物理 · 物理学 2019-09-04 Xiao Liang , Liyuan Chen , Dan Nguyen , Zhiguo Zhou , Xuejun Gu , Ming Yang , Jing Wang , Steve Jiang

Background: Limited-angle (LA) dual-energy (DE) cone-beam CT (CBCT) is considered as a potential solution to achieve fast and low-dose DE imaging on current CBCT scanners without hardware modification. However, its clinical implementations…

Whole-body Positron Emission Tomography (PET) registration is essential for multi-parametric tumor characterization and assessment of metastatic disease progression. In deep learning-based deformable registration, the dense displacement…

图像与视频处理 · 电气工程与系统科学 2026-04-28 Xiangcen Wu , Ruohua Chen , Sichun Li , Qianye Yang , Sheng Liu , Jianjun Liu , Zhaoheng Xie

CBCTs in image-guided radiotherapy provide crucial anatomy information for patient setup and plan evaluation. Longitudinal CBCT image registration could quantify the inter-fractional anatomic changes. The purpose of this study is to propose…

图像与视频处理 · 电气工程与系统科学 2023-04-26 Huiqiao Xie , Yang Lei , Yabo Fu , Tonghe Wang , Justin Roper , Jeffrey D. Bradley , Pretesh Patel , Tian Liu , Xiaofeng Yang

The accuracy of deformable image registration (DIR) has a significant dosimetric impact in radiation treatment planning. We evaluated accuracy of various DIR algorithms using variations of the deformation point and volume. The reference…

Purpose: This study aims to explore training strategies to improve convolutional neural network-based image-to-image deformable registration for abdominal imaging. Methods: Different training strategies, loss functions, and transfer…

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