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In this review article, we focus on emerging nanocantilever based biological sensors and discuss the response of nanocantilevers towards bio-molecules capture. The article guides the reader through various modes of operation (e.g., static…

仪器与探测器 · 物理学 2013-05-30 Ankit Jain , Muhammad Ashraful Alam

In this chapter, silicon nanowires that are compatible with CMOS fabrication processes have been described. It has been shown that these nanowires can be functionalized by conjugating monoclonal antibodies to their surface in order to build…

A technology for recording electrical activity of large neuron populations at arbitrary depth in brain tissues with less than cell spatial and millisecond temporal resolutions was the most craving dream of neuroscientists and a long pursued…

生物物理 · 物理学 2013-09-02 Roman V. Beletskiy

Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the…

应用物理 · 物理学 2017-08-02 Ozlem Yavas , Mikael Svedendahl , Paulina Dobosz , Vanesa Sanz , Romain Quidant

Nanoscale biosensors are devices designed to detect analytes by combining biological components and physicochemical detectors. One of the well known methods of constructing these sensors is by using nanocantilevers. These microscopic…

生物物理 · 物理学 2014-09-16 Patrick Snyder , Amitabh Joshi , Juan D. Serna

Integrated chemical and biological sensors give advantages in cost, size and weight reduction and open new prospects for parallel monitoring and analysis. Biosensors based on nanoelectromechanical systems (NEMS) are the most attractive…

光学 · 物理学 2019-04-29 Dmitry Yu. Fedyanin , Yury V. Stebunov

Nanomechanical systems offer a versatile platform for both fundamental science and industrial applications. Resonating vibration has been demonstrated to enable an ultrasensitive detection of various physical quantities, with emerging…

Cell-based biosensors constitute a fundamental tool in biotechnology, and their relevance has greatly increased in recent years as a result of a surging demand for reduced animal testing and for high-throughput and cost-effective in vitro…

Silicon nanochannel field effect transistor (FET) biosensors are one of the most promising technologies in the development of highly sensitive and label-free analyte detection for cancer diagnostics. With their exceptional electrical…

Biosensors are essential tools which have been traditionally used to monitor environmental pollution, detect the presence of toxic elements and biohazardous bacteria or virus in organic matter and biomolecules for clinical diagnostics. In…

化学物理 · 物理学 2021-01-08 Aishwaryadev Banerjee , Swagata Maity , Carlos H. Mastrangelo

Single-chip CMOS-based biosensors that feature microcantilevers as transducer elements are presented. The cantilevers are functionalized for the capturing of specific analytes, e.g., proteins or DNA. The binding of the analyte changes the…

硬件体系结构 · 计算机科学 2011-11-09 K. -U. Kirstein , Y. Li , M. Zimmermann , C. Vancura , T. Volden , W. H. Song , J. Lichtenberg , A. Hierlemannn

Graphene based nanomaterials have attracted significant attention for their potentials in biomedical and biotechnology applications in recent years, owing to the outstanding physical and chemical properties. However, the interaction…

生物大分子 · 定量生物学 2024-04-09 Jing Ye , Minzhi Fan , Xiaoyu Zhang , Shasha Lu , Mengyao Chai , Yunshan Zhang , Xiaoyu Zhao , Shuang Li , Diming Zhang

We developed a process to fabricate nanoscale metallic gate electrodes on scanning probe cantilevers, including on the irregular surface of protruding cantilever tips. The process includes a floating-layer technique to coat the cantilevers…

仪器与探测器 · 物理学 2022-09-26 Luca Forrer , Aurèle Kamber , Armin Knoll , Martino Poggio , Floris Braakman

Three-dimensional (3D) printing of bioelectronics offers a versatile platform for fabricating personalized and structurally integrated electronic systems within biological scaffolds. Biodegradable electronics, which naturally dissolve after…

We present a method where a bioactive functional layer on an electrically conductive thin film with high sheet resistance can be effectively used for complementary electrochemical impedance spectroscopy biosensing. The functional layer's…

材料科学 · 物理学 2025-04-04 Munis Khan , Ivan Mijakovic , Santosh Pandit , August Yurgens

Silicon-based photonic biosensors, such as microring resonators and Mach-Zehnder interferometers, offer significant potential for the detection of analytes at low concentrations. To enhance response time and improve the limit of detection…

光学 · 物理学 2024-07-01 Anders Henriksson , Peter Neubauer , Mario Birkholz

In electrophysiology, multielectrode array devices (MEA) are the gold standard for the study of large ensambles of electrogenic cells. In the last decades, thanks to the adoption of nanotechnologies, the study of physiological and…

生物物理 · 物理学 2023-01-24 Giulia Bruno

Silicon nanochannel biological field effect transistors have been developed for glucose detection. The device is nanofabricated from a silicon-on-insulator wafer with a top-down approach and surface functionalized with glucose oxidase. The…

生物物理 · 物理学 2008-02-14 Xihua Wang , Yu Chen , Katherine A. Gibney , Shyamsunder Erramilli , Pritiraj Mohanty

Biological systems have been theoretically predicted to support phononic topological wave-modes, similar to the ones existing in meta-materials. The existing methods to measure these modes, however cannot be applied to biological systems;…

生物物理 · 物理学 2023-03-03 Ssu-Ying Chen , Arooj Aslam , David J. Apigo , Sagnik Basuray , Camelia Prodan

Visible and infrared photons can be detected with a broadband response via the internal photoeffect. By using plasmonic nanostructures, i.e. nanoantennas, wavelength selectivity can be introduced to such detectors through geometry-dependent…

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