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Biological systems represent time from microseconds to years. An important gap in our knowledge concerns the mechanisms for encoding time intervals of hundreds of milliseconds to minutes that matter for tasks like navigation, communication,…

神经元与认知 · 定量生物学 2025-05-22 Raphaël Lafond-Mercier , Leonard Maler , Avner Wallach , André Longtin

The integration of neural representations in the two hemispheres is an important problem in neuroscience. Recent experiments revealed that odor responses in cortical neurons driven by separate stimulation of the two nostrils are highly…

神经元与认知 · 定量生物学 2024-12-17 Bo Liu , Shanshan Qin , Venkatesh Murthy , Yuhai Tu

At the single-neuron level, precisely timed spikes can either constitute firing-rate codes or spike-pattern codes that utilize the relative timing between consecutive spikes. There has been little experimental support for the hypothesis…

神经元与认知 · 定量生物学 2009-12-18 Hugo Gabriel Eyherabide , Ariel Rokem , Andreas V. M. Herz , Ines Samengo

The spiking neural network (SNN) mimics the information processing operation in the human brain, represents and transmits information in spike trains containing wealthy spatial and temporal information, and shows superior performance on…

神经与进化计算 · 计算机科学 2021-10-25 Guobin Shen , Dongcheng Zhao , Yi Zeng

Biological circuits have evolved to incorporate multiple modules that perform similar functions. In the fly olfactory circuit, both lateral inhibition (LI) and neuronal spike frequency adaptation (SFA) are thought to enhance pattern…

神经与进化计算 · 计算机科学 2025-10-27 Haiyang Li , Liao Yu , Qiang Yu , Yunliang Zang

Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant…

神经元与认知 · 定量生物学 2007-05-23 Ilya Nemenman , Geoffrey D. Lewen , William Bialek , Rob R. de Ruyter van Steveninck

Neurons in the nervous system convey information to higher brain regions by the generation of spike trains. An important question in the field of computational neuroscience is how these sensory neurons encode environmental information in a…

神经元与认知 · 定量生物学 2013-09-13 Alex Susemihl , Ron Meir , Manfred Opper

In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We propose a novel strategy for encoding intensity-invariant stimuli identity that is based on…

神经元与认知 · 定量生物学 2016-09-09 Daniel Kepple , Hamza Giaffar , Dmitry Rinberg , Alexei Koulakov

The computation performed by a neuron can be formulated as a combination of dimensional reduction in stimulus space and the nonlinearity inherent in a spiking output. White noise stimulus and reverse correlation (the spike-triggered average…

生物物理 · 物理学 2007-05-23 Blaise Aguera y Arcas , Adrienne Fairhall

Sensory processing is hard because the variables of interest are encoded in spike trains in a relatively complex way. A major goal in sensory processing is to understand how the brain extracts those variables. Here we revisit a common…

神经元与认知 · 定量生物学 2017-09-06 Sina Tootoonian , Peter Latham

Determining how synaptic coupling within and between regions is modulated during sensory processing is an important topic in neuroscience. Electrophysiological recordings provide detailed information about neural spiking but have…

神经元与认知 · 定量生物学 2018-02-07 Andrea K. Barreiro , Shree Hari Gautam , Woodrow L. Shew , Cheng Ly

Spike sorting refers to the problem of assigning action potentials observed in extra-cellular recordings of neural activity to the neuron(s) from which they originate. We cast this problem as one of learning a convolutional dictionary from…

统计方法学 · 统计学 2018-06-07 Andrew H. Song , Francisco Flores , Demba Ba

Neural noise sets a limit to information transmission in sensory systems. In several areas, the spiking response (to a repeated stimulus) has shown a higher degree of regularity than predicted by a Poisson process. However, a simple model…

神经元与认知 · 定量生物学 2018-01-08 Ulisse Ferrari , Stephane Deny , Olivier Marre , Thierry Mora

Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology, and though experiments that…

神经元与认知 · 定量生物学 2022-10-12 Edward D. Lee , Xiaowen Chen , Bryan C. Daniels

Extracellular recordings of single neurons in primary and secondary somatosensory cortices of monkeys in vivo have shown that their firing rate can increase, decrease, or remain constant in different cells, as the external stimulus…

神经元与认知 · 定量生物学 2012-03-06 Jing Kang , Hugh P. C. Robinson , Jianfeng Feng

Sensory neurons are often described in terms of a receptive field, that is, a linear kernel through which stimuli are filtered before they are further processed. If information transmission is assumed to proceed in a feedforward cascade,…

神经元与认知 · 定量生物学 2015-03-11 Eugenio Urdapilleta , Inés Samengo

Storing memory for molecular recognition is an efficient strategy for responding to external stimuli. Biological processes use different strategies to store memory. In the olfactory cortex, synaptic connections form when stimulated by an…

生物物理 · 物理学 2021-06-07 Oskar H Schnaack , Luca Peliti , Armita Nourmohammad

A synfire chain is a simple neural network model which can propagate stable synchronous spikes called a pulse packet and widely researched. However how synfire chains coexist in one network remains to be elucidated. We have studied the…

神经元与认知 · 定量生物学 2009-11-13 Kazuya Ishibashi , Kosuke Hamaguchi , Masato Okada

Despite rapid adoption and deployment of large language models (LLMs), the internal computations of these models remain opaque and poorly understood. In this work, we seek to understand how high-level human-interpretable features are…

机器学习 · 计算机科学 2023-06-06 Wes Gurnee , Neel Nanda , Matthew Pauly , Katherine Harvey , Dmitrii Troitskii , Dimitris Bertsimas

This study proposes a novel learning paradigm for spiking neural networks (SNNs) that replaces the perceptron-inspired abstraction with biologically grounded neuron models, jointly optimizing synaptic weights and intrinsic neuronal…

神经与进化计算 · 计算机科学 2026-03-03 Zofia Rudnicka , Janusz Szczepanski , Agnieszka Pregowska