相关论文: On the tradeoff between treatment time and plan qu…

We propose a novel optimization model for volumetric modulated arc therapy (VMAT) planning that directly optimizes deliverable leaf trajectories in the treatment plan optimization problem, and eliminates the need for a separate…

In recent years, volumetric modulated arc therapy (VMAT) has been becoming a more and more important radiation technique widely used in clinical application for cancer treatment. One of the key problems in VMAT is treatment plan…

The purpose of this study is to give an exact formulation of optimization of volumetric-modulated arc therapy (VMAT) with sliding-window delivery, and to investigate the plan quality effects of decreasing the number of sliding-window sweeps…

Stereotactic body radiotherapy (SBRT) is characterized by delivering a high amount of dose in a short period of time. In SBRT the dose is delivered using open fields (e.g., beam's-eye-view) known as "apertures". Mathematical methods can be…

In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment delivery methods, such as IMRT, VMAT, tomotherapy, LDR/HDR…

In this article we provide a method to generate the trade-off between delivery time and fluence map matching quality for volumetric modulated arc therapy (VMAT). At the heart of our method lies a mathematical programming model that, for a…

In this first paper of a two-paper series, we present a method for optimizing the dynamic delivery of fluence maps in radiation therapy. For a given fluence map and a given delivery time, the optimization of the leaf trajectories of a…

This report presents a design of a gantry for proton therapy based on the concept of adiabatic transition. The use of fixed-field alternating gradient magnets allows a large momentum acceptance and supports fast energy modulation. The…

The physical and clinical benefits of charged particle therapy (CPT) are well recognised and recent developments have led to the rapid emergence of facilities, resulting in wider adoption worldwide. Nonetheless, the availability of CPT and…

Within the setting of intensity modulated radiation therapy (IMRT) and the fully continuous version of IMRT called volumetric modulated radiation therapy (VMAT), we consider the problem of matching a given fluence map as well as possible in…

A central problem in the field of radiation therapy (RT) is how to optimally deliver dose to a patient in a way that fully accounts for anatomical position changes over time. As current RT is a static process, where beam intensities are…

In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem…

Background: Proton arc therapy is an emerging radiation therapy technique where either the gantry or the patient continuously rotates during the irradiation treatment. One of the perceived advantages of proton arc therapy is the reduced…

A new strategy for radiation therapy dosimetry planning (RTDP) used to reduce dose estimation errors due to respiratory motion in breast treatment was illustrated and evaluated in this study. On CT data set acquired for breast treatment,…

Intensity-modulated proton therapy (IMPT) offers superior dose conformity with reduced exposure to surrounding healthy tissues compared to conventional photon therapy. Improving IMPT delivery efficiency reduces motion-related uncertainties,…

In robotic radiation therapy, high-energy photon beams from different directions are directed at a target within the patient. Target motion can be tracked by robotic ultrasound and then compensated by synchronous beam motion. However,…

Radiotherapy is a crucial cancer treatment that demands precise planning to balance tumor eradication and preservation of healthy tissue. Traditional treatment planning (TP) is iterative, time-consuming, and reliant on human expertise,…

Background and Purpose: Increasing the number of arcs in volumetric modulated arc therapy (VMAT) allows for better intensity modulation and may improve plan quality. However, this leads to longer delivery times, which may cause patient…

Traditional VMAT optimization often ignores dynamic machine limits, treating delivery time as an emergent property rather than a steerable parameter. This work introduces Dynamic Modulated Arc Therapy (DMAT), an intent-driven framework that…

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…