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Detecting changepoints in a time series of length $N$ entails evaluating up to $2^{N-1}$ possible changepoint models, making exhaustive enumeration computationally infeasible. Genetic algorithms (GAs) provide a stochastic way to identify…

统计计算 · 统计学 2025-09-30 Mo Li , QiQi Lu

We propose an on-chip mid-infrared (MIR) photonic spectroscopy platform for aerosol characterization to obtain highly discriminatory information on the chemistry of aerosol particles. Sensing of aerosols is crucial for various…

应用物理 · 物理学 2020-05-12 Robin Singh , Peter Su , Lionel Kimerling , Anu Agarwal , Brian W Anthony

Deep neural networks demonstrate strong performance under aligned training-test distributions. However, real-world test data often exhibit domain shifts. Test-Time Adaptation (TTA) addresses this challenge by adapting the model to test data…

人工智能 · 计算机科学 2025-08-27 Byung-Joon Lee , Jin-Seop Lee , Jee-Hyong Lee

Increasing the angular resolution of an interferometric array requires placing its elements at large separations. This often leads to sparse coverage and introduces challenges to reconstructing images from interferometric data. We introduce…

天体物理仪器与方法 · 物理学 2024-12-04 Dimitrios Psaltis , Feryal Ozel , Yassine Ben Zineb

Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin…

Antibiotic Resistance (AR) is a critical global health challenge that necessitates the development of cost-effective, efficient, and accurate diagnostic tools. Given the genetic basis of AR, techniques such as Polymerase Chain Reaction…

定量方法 · 定量生物学 2025-02-24 David Hagerman , Anna Johnning , Roman Naeem , Fredrik Kahl , Erik Kristiansson , Lennart Svensson

Motivation: ``Molecular signatures'' or ``gene-expression signatures'' are used to predict patients' characteristics using data from coexpressed genes. Signatures can enhance understanding about biological mechanisms and have diagnostic…

定量方法 · 定量生物学 2007-05-23 Ramon Diaz-Uriarte

Systems biology is an inter-disciplinary field that studies systems of biological components at different scales, which may be molecules, cells or entire organism. In particular, systems biology methods are applied to understand functional…

计算工程、金融与科学 · 计算机科学 2014-12-22 Thomas Cokelaer , Julio Saez-Rodriguez

The BRITE mission is a pioneering space project aimed at the long-term photometric monitoring of the brightest stars in the sky by means of a constellation of nano-satellites. Its main advantage is high photometric accuracy and time…

Functional near-infrared spectroscopy (fNIRS) is a non-invasive optical technique that measures brain activity by estimating blood oxygenation using near-infrared light. Traditionally, PsychoPy is used in many studies to send task-specific…

人机交互 · 计算机科学 2024-11-19 Shayla Sharmin , Md Fahim Abrar , Roghayeh Leila Barmaki

Analyzing array-based computations to determine data dependences is useful for many applications including automatic parallelization, race detection, computation and communication overlap, verification, and shape analysis. For sparse matrix…

Understanding the abundance pattern of metal-poor stars and the production of heavy elements through various nucleosynthesis processes offers crucial insights into the chemical evolution of the Milky Way, revealing primary sites and major…

Interstellar filaments are an important part of star formation. To understand the structure of filaments, cross-section profiles are often fitted with Plummer profiles. This profiling is often done with submm studies, such as Herschel. It…

星系天体物理 · 物理学 2015-06-05 J. Malinen , M. Juvela , M. G. Rawlings , D. Ward-Thompson , P. Palmeirim , Ph. Andre

Hematoxylin and eosin (H&E) staining is the clinical standard for assessing tissue morphology, but it lacks molecular-level diagnostic information. In contrast, immunohistochemistry (IHC) provides crucial insights into biomarker expression,…

图像与视频处理 · 电气工程与系统科学 2025-08-05 Jingsong Liu , Xiaofeng Deng , Han Li , Azar Kazemi , Christian Grashei , Gesa Wilkens , Xin You , Tanja Groll , Nassir Navab , Carolin Mogler , Peter J. Schüffler

Fluorescence microscopy reveals that the contents of many (membrane-free) nuclear "bodies" exchange rapidly with the soluble pool whilst the underlying structure persists; such observations await a satisfactory biophysical explanation. To…

生物物理 · 物理学 2017-04-26 C. A. Brackley , B. Liebchen , D. Michieletto , F. Mouvet , P. R. Cook , D. Marenduzzo

As protein therapeutics play an important role in almost all medical fields, numerous studies have been conducted on proteins using artificial intelligence. Artificial intelligence has enabled data driven predictions without the need for…

定量方法 · 定量生物学 2023-03-30 Myeonghun Lee , Kyoungmin Min

The identification and validation of therapeutic antibodies is critical for developing effective treatments for many diseases. We present a computational approach for identifying antibodies targeting GFRAL-specific receptors, receptors…

This report presents a generic image registration benchmark with automatic evaluation using landmark annotations. The key features of the BIRL framework are: easily extendable, performance evaluation, parallel experimentation, simple…

计算机视觉与模式识别 · 计算机科学 2020-01-22 Jiri Borovec

Accurate whole-cell and nuclear segmentation is essential for precision pathology and spatial omics, yet routine hematoxylin and eosin (H&E) staining provides limited cytoplasmic contrast, restricting analyses to nuclei. Multiplex…

In computational biology and bioinformatics, the manner to understand evolution processes within various related organisms paid a lot of attention these last decades. However, accurate methodologies are still needed to discover genes…

神经与进化计算 · 计算机科学 2016-11-15 Bassam AlKindy , Christophe Guyeux , Jean-François Couchot , Michel Salomon , Jacques M. Bahi