相关论文: Starr: Simple Tiling Array Analysis of Affymetrix …
Nulling interferometry is a powerful observing technique to reach exoplanets and circumstellar dust at separations too small for direct imaging with single-dish telescopes and too large for indirect methods. With near-future…
Differential co-expression analysis has been widely applied by scientists in understanding the biological mechanisms of diseases. However, the unknown differential patterns are often complicated; thus, models based on simplified parametric…
Stellar population studies provide unique clues to constrain galaxy formation models. So far, detailed studies based on absorption line strengths have mainly focused on the optical spectral range although many diagnostic features are…
Nanopore sequencing is a widely-used high-throughput genome sequencing technology that can sequence long fragments of a genome into raw electrical signals at low cost. Nanopore sequencing requires two computationally-costly processing steps…
The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both…
The surfaces of rotating stars serve as a window into their interiors, magnetic dynamos, and are important in other areas including exoplanet discovery and atmospheric characterization. While indirect techniques such as photometry and…
DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications, since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The…
The chromatin folding and the spatial arrangement of chromosomes in the cell play a crucial role in DNA replication and genes expression. An improper chromatin folding could lead to malfunctions and, over time, diseases. For eukaryotes,…
The integrity of the reconstructed human epidermis generated in vitro could be assessed using histological analyses combined with immunohistochemical staining of keratinocyte differentiation markers. Computer-based analysis of scanned…
Traditional artificial-star tests are widely applied to photometry in crowded stellar fields. However, to obtain reliable binary fractions (and their uncertainties) of remote, dense, and rich star clusters, one needs to recover huge numbers…
Line intensity mapping (LIM) experiments probing the nearby universe can expect a considerable amount of cosmic infrared background (CIB) contiuum emission coming from near and far-infrared galaxies. For the purpose of using the LIM data to…
We investigate the measurement of DNA supercoiling density ($\sigma$) along chromosomes using interaction frequencies between DNA and DNA-anchored clusters of proteins. Specifically, we show how the physics of DNA supercoiling leads, in…
The color appearance of a pathological image is highly related to the imaging protocols, the proportion of different dyes, and the scanning devices. Computer-aided diagnostic systems may deteriorate when facing these color-variant…
Detecting variation in the evolutionary process along chromosomes is increasingly important as whole-genome data becomes more widely available. For example, factors such as incomplete lineage sorting, horizontal gene transfer, and…
Research in bioinformatics is a complex phenomenon as it overlaps two knowledge domains, namely, biological and computer sciences. This paper has tried to introduce an efficient data mining approach for classifying proteins into some useful…
Accurate diagnostic tests are essential for effective screening and treatment. However, individual biomarkers often fail to provide sufficient diagnostic accuracy, as they typically capture only one aspect of the complex disease process.…
Multiplexed, specific and sensitive detection of antigens is critical for the rapid and accurate diagnosis of disease and the informed development of personalized treatment plans. Here, we show that polymer microsphere lasers can be used as…
The STAR experiment at the Relativistic Heavy-Ion Collider at Brookhaven National Laboratory is carrying out a spin physics program in high-energy polarized $\vec{p}+\vec{p}$ collisions at $\sqrt{s}=200-500\,$GeV to gain a deeper insight…
Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…
Tomographic imaging has benefited from advances in X-ray sources, detectors and optics to enable novel observations in science, engineering and medicine. These advances have come with a dramatic increase of input data in the form of faster…