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In this paper, we propose a mean-field model which attempts to bridge the gap between random Boolean networks and more realistic stochastic modeling of genetic regulatory networks. The main idea of the model is to replace all regulatory…

定量方法 · 定量生物学 2009-11-13 M. Andrecut , S. A. Kauffman

We provide the first classification of different types of Random Boolean Networks (RBNs). We study the differences of RBNs depending on the degree of synchronicity and determinism of their updating scheme. For doing so, we first define…

计算复杂性 · 计算机科学 2007-05-23 Carlos Gershenson

The dynamical organization in the presence of noise of a Boolean neural network with random connections is analyzed. For low levels of noise, the system reaches a stationary state in which the majority of its elements acquire the same…

无序系统与神经网络 · 物理学 2007-05-23 Cristian Huepe , Maximino Aldana

Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this…

最优化与控制 · 数学 2016-06-07 Kenji Kashima

Effective control of biological systems can often be achieved through the control of a surprisingly small number of distinct variables. We bring clarity to such results using the formalism of Boolean dynamical networks, analyzing the…

分子网络 · 定量生物学 2021-09-13 Enrico Borriello , Bryan C. Daniels

Continuous-time systems with switch-like behaviour occur in chemical kinetics, gene regulatory networks and neural networks. Networks with hard switching, as a limiting case of smooth sigmoidal switching, retain the richest possible range…

动力系统 · 数学 2019-05-10 Roderick Edwards

We realize autonomous Boolean networks by using logic gates in their autonomous mode-of-operation on a field-programmable gate array. This allows us to implement time-continuous systems with complex dynamical behaviors that can be…

适应与自组织系统 · 物理学 2013-12-16 David P. Rosin , Damien Rontani , Daniel J. Gauthier , Eckehard Schöll

Random Boolean networks (RBNs) are frequently employed for modelling complex systems driven by information processing, e.g. for gene regulatory networks (GRNs). Here we propose a hierarchical adaptive RBN (HARBN) as a system consisting of…

物理与社会 · 物理学 2016-03-23 Piotr J. Gorski , Agnieszka Czaplicka , Janusz A. Holyst

Boolean networks have been widely used to explore aspects of gene regulation, traditionally with a single network. A modified form of the model to explore the effects of increasing the number of gene states has also recently been…

分子网络 · 定量生物学 2024-01-22 Larry Bull

We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a…

分子网络 · 定量生物学 2010-12-07 Volkan Sevim , Per Arne Rikvold

Random Boolean networks, the Kauffman model, are revisited by means of a novel decimation algorithm, which reduces the networks to their dynamical cores. The average size of the removed part, the stable core, grows approximately linearly…

统计力学 · 物理学 2009-11-07 S. Bilke , F. Sjunnesson

The characterization of the "most connected" nodes in static or slowly evolving complex networks has helped in understanding and predicting the behavior of social, biological, and technological networked systems, including their robustness…

物理与社会 · 物理学 2010-10-21 Scott A. Hill , Dan Braha

Different Boolean networks may reveal similar dynamics although their definition differs, then preventing their distinction from the observations. This raises the question about the sufficiency of a particular Boolean network for properly…

离散数学 · 计算机科学 2014-11-25 Franck Delaplace

Despite their apparent simplicity, random Boolean networks display a rich variety of dynamical behaviors. Much work has been focused on the properties and abundance of attractors. We here derive an expression for the number of attractors in…

分子网络 · 定量生物学 2007-05-23 Björn Samuelsson , Carl Troein

The research concerns the dynamics of complex autonomous Kauffman networks. The article defines and shows using simulation experiments half-chaotic networks, which exhibit features much more similar to typically modeled systems like a…

适应与自组织系统 · 物理学 2022-01-14 Andrzej Gecow

This paper is concerned with the problem of stochastic control of gene regulatory networks (GRNs) observed indirectly through noisy measurements and with uncertainty in the intervention inputs. The partial observability of the gene states…

分子网络 · 定量生物学 2017-02-27 Mahdi Imani , Ulisses Braga-Neto

Training neural networks sequentially in time to approximate solution fields of time-dependent partial differential equations can be beneficial for preserving causality and other physics properties; however, the sequential-in-time training…

机器学习 · 计算机科学 2023-10-10 Jules Berman , Benjamin Peherstorfer

Our daily social and political life is more and more impacted by social networks. The functioning of our living bodies is deeply dependent on biological regulation networks such as neural, genetic, and protein networks. And the physical…

离散数学 · 计算机科学 2022-04-25 Jacques Demongeot , Tarek Melliti , Mathilde Noual , Damien Regnault , Sylvain Sené

The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

生物物理 · 物理学 2015-05-13 Sitabhra Sinha

We investigate the effect of noise on Random Boolean Networks. Noise is implemented as a probability $p$ that a node does not obey its deterministic update rule. We define two order parameters, the long-time average of the Hamming distance…

生物物理 · 物理学 2009-11-13 Tiago P. Peixoto , Barbara Drossel