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X-ray imaging is a fundamental tool of routine clinical diagnosis. Fluoroscopic imaging can further acquire X-ray images at video frame rates, thus enabling non-invasive in-vivo motion studies of joints, gastrointestinal tract, etc. For…
Today Gadolinium-based contrast agents (GBCA) are indispensable in Magnetic Resonance Imaging (MRI) for diagnosing various diseases. However, GBCAs are expensive and may accumulate in patients with potential side effects, thus…
Photoacoustic tomography is a hybrid biomedical technology, which combines the advantages of acoustic and optical imaging. However, for the conventional image reconstruction method, the image quality is affected obviously by artifacts under…
We treat an image restoration problem with a Poisson noise chan- nel using a Bayesian framework. The Poisson randomness might be appeared in observation of low contrast object in the field of imaging. The noise observation is often hard to…
Computed tomography from a low radiation dose (LDCT) is challenging due to high noise in the projection data. Popular approaches for LDCT image reconstruction are two-stage methods, typically consisting of the filtered backprojection (FBP)…
Low-dose computed tomography (LDCT) reconstruction faces a critical tradeoff between reconstruction quality and resource requirements. While recent deep learning methods achieve state-of-the-art performance, they typically rely on over…
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline. [$^{18}$F]-Fluorodeoxyglucose positron emission tomography ([$^{18}$F]-FDG PET) is used to monitor brain metabolism, aiding in the diagnosis…
Low-dose computed tomography (LDCT) reduces radiation exposure but also introduces substantial noise and structural degradation, making it difficult to suppress noise without erasing subtle anatomical details. In this paper, we present…
Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite…
Images from positron emission tomography (PET) provide metabolic information about the human body. They present, however, a spatial resolution that is limited by physical and instrumental factors often modeled by a blurring function. Since…
Generating synthetic CT (sCT) from MRI or CBCT plays a crucial role in enabling MRI-only and CBCT-based adaptive radiotherapy, improving treatment precision while reducing patient radiation exposure. To address this task, we adopt a fully…
Traditional voxel-level multiple testing procedures in neuroimaging, mostly $p$-value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the…
Assessing coronary artery plaque segments in coronary CT angiography scans is an important task to improve patient management and clinical outcomes, as it can help to decide whether invasive investigation and treatment are necessary. In…
Purpose: Digital phantoms are one of the key components of virtual imaging trials (VITs) that aim to assess and optimize new medical imaging systems and algorithms. However, these phantoms vary in their voxel resolution, appearance, and…
Purpose: Analysis of [18F]-Fluorodeoxyglucose (FDG) kinetics in cancer has been most often limited to the evaluation of the average uptake over relatively large volumes. Nevertheless, tumor lesion almost contains inflammatory infiltrates…
Quantum correlations become formidable tools for beating classical capacities of measurement. Preserving these advantages in practical systems, where experimental imperfections are unavoidable, is a challenge of the utmost importance. Here…
The estimation of grayscale images using their single-bit zero mean Gaussian noise-affected pixels is presented in this paper. The images are assumed to be bandlimited in the Fourier Cosine transform (FCT) domain. The images are oversampled…
Accurate quantification in positron emission tomography (PET) is essential for accurate diagnostic results and effective treatment tracking. A major issue encountered in PET imaging is attenuation. Attenuation refers to the diminution of…
Current 3D photoacoustic tomography (PAT) systems offer either high image quality or high frame rates but are not able to deliver high spatial and temporal resolution simultaneously, which limits their ability to image dynamic processes in…
Background: Spectral shaping is a computed tomography (CT) dose optimization technique that adjusts source voltage and filtration to reduce patient radiation exposure without compromising image quality. Traditionally, radiation dose has…