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Understanding the spatial architecture of the tumor microenvironment (TME) is critical to advance precision oncology. We present ProteinPNet, a novel framework based on prototypical part networks that discovers TME motifs from spatial…

机器学习 · 计算机科学 2025-12-03 Louis McConnell , Jieran Sun , Theo Maffei , Raphael Gottardo , Marianna Rapsomaniki

Protein structure prediction has been a grand challenge for over 50 years, owing to its broad scientific and application interests. There are two primary types of modeling algorithms, template-free modeling and template-based modeling. The…

生物物理 · 物理学 2021-06-01 Liangzhen Zheng , Haidong Lan , Tao Shen , Jiaxiang Wu , Sheng Wang , Wei Liu , Junzhou Huang

In this work, we propose a simple but effective channel pruning framework called Progressive Channel Pruning (PCP) to accelerate Convolutional Neural Networks (CNNs). In contrast to the existing channel pruning methods that prune channels…

计算机视觉与模式识别 · 计算机科学 2025-07-08 Jinyang Guo , Weichen Zhang , Wanli Ouyang , Dong Xu

Spectrum sharing allows different protocols of the same standard (e.g., 802.11 family) or different standards (e.g., LTE and DVB) to coexist in overlapping frequency bands. As this paradigm continues to spread, wireless systems must also…

Incorporating individual-level cognitive priors offers an important route to personalizing neural networks, yet accurately eliciting such priors remains challenging: existing methods either fail to uniquely identify them or introduce…

计算机视觉与模式识别 · 计算机科学 2026-02-05 Haijiang Yan , Nick Chater , Adam Sanborn

Cross-Database Micro-Expression Recognition (CDMER) aims to develop the Micro-Expression Recognition (MER) methods with strong domain adaptability, i.e., the ability to recognize the Micro-Expressions (MEs) of different subjects captured by…

计算机视觉与模式识别 · 计算机科学 2022-07-06 Xingxun Jiang , Yuan Zong , Wenming Zheng , Jiateng Liu , Mengting Wei

Undersampling is a common method in Magnetic Resonance Imaging (MRI) to subsample the number of data points in k-space, reducing acquisition times at the cost of decreased image quality. A popular approach is to employ undersampling…

图像与视频处理 · 电气工程与系统科学 2023-08-23 Tobias Weber , Michael Ingrisch , Bernd Bischl , David Rügamer

Motivation: Protein surface roughness is fractal in nature. Mass, hydrophobicity, polarizability distributions of protein interior are fractal too, as are the distributions of dipole moments, aromatic residues, and many other structural…

生物大分子 · 定量生物学 2012-12-11 Charudatta Navare , Anirban Banerji

The binding of a transcription factor (TF) to a DNA operator site can initiate or repress the expression of a gene. Computational prediction of sites recognized by a TF has traditionally relied upon knowledge of several cognate sites,…

生物大分子 · 定量生物学 2008-11-10 Sahand Jamal Rahi , Peter Virnau , Leonid A. Mirny , Mehran Kardar

As the size of accessible compound libraries expands to over 10 billion, the need for more efficient structure-based virtual screening methods is emerging. Different pre-screening methods have been developed for rapid screening, but there…

生物大分子 · 定量生物学 2025-03-07 Seonghwan Seo , Woo Youn Kim

Models of radiative transfer (RT) are important tools for remote sensing of vegetation, as they facilitate forward simulations of remotely sensed data as well as inverse estimation of biophysical and biochemical properties from vegetation…

定量方法 · 定量生物学 2020-03-27 Jean-Baptiste Féret , Katja Berger , Florian de Boissieu , Zbyněk Malenovský

Forecasting complex time series is an important yet challenging problem that involves various industrial applications. Recently, masked time-series modeling has been proposed to effectively model temporal dependencies for forecasting by…

机器学习 · 计算机科学 2025-07-02 Hyunwoo Seo , Chiehyeon Lim

Detecting weak target is an important and challenging problem in many applications such as radar, sonar etc. However, conventional detection methods are often ineffective in this case because of low signal-to-noise ratio (SNR). This paper…

信号处理 · 电气工程与系统科学 2023-09-26 Jin Lu , Guojie Peng , Weichuan Zhang , Changming Sun

We present data preprocessing based on an artificial neural network to estimate the parameters of the X-ray emission spectra of a single-temperature thermal plasma. The method finds appropriate parameters close to the global optimum. The…

天体物理仪器与方法 · 物理学 2018-05-15 Y. Ichinohe , S. Yamada , N. Miyazaki , S. Saito

The objective of this work is to explore how to effectively and efficiently adapt pre-trained visual foundation models to various downstream tasks of semantic segmentation. Previous methods usually fine-tuned the entire networks for each…

计算机视觉与模式识别 · 计算机科学 2022-11-22 Lingbo Liu , Jianlong Chang , Bruce X. B. Yu , Liang Lin , Qi Tian , Chang-Wen Chen

The limits of molecular dynamics (MD) simulations of macromolecules are steadily pushed forward by the relentless developments of computer architectures and algorithms. This explosion in the number and extent (in size and time) of MD…

Face recognition models have made substantial progress due to advances in deep learning and the availability of large-scale datasets. However, reliance on massive annotated datasets introduces challenges related to training computational…

计算机视觉与模式识别 · 计算机科学 2025-05-22 Eduarda Caldeira , Jan Niklas Kolf , Naser Damer , Fadi Boutros

Souper is a powerful enumerative superoptimizer that enhances the runtime performance of programs by optimizing LLVM intermediate representation (IR) code. However, its verification process, which relies on a computationally expensive SMT…

新兴技术 · 计算机科学 2025-09-23 Ange-Thierry Ishimwe , Raghuveer Shivakumar , Heewoo Kim , Tamara Lehman , Joseph Izraelevitz

In the literature, two series of models have been proposed to address prediction problems including classification and regression. Simple models, such as generalized linear models, have ordinary performance but strong interpretability on a…

机器学习 · 计算机科学 2016-11-01 Jingbo Shang , Meng Jiang , Wenzhu Tong , Jinfeng Xiao , Jian Peng , Jiawei Han

An accurate binding affinity prediction between T-cell receptors and epitopes contributes decisively to develop successful immunotherapy strategies. Some state-of-the-art computational methods implement deep learning techniques by…

机器学习 · 计算机科学 2024-01-18 Etienne Goffinet , Raghvendra Mall , Ankita Singh , Rahul Kaushik , Filippo Castiglione