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Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells. In the context of traffic-like…

生物物理 · 物理学 2009-04-16 Debashish Chowdhury

Molecular motors perform active movements along cytoskeletal filaments and drive the traffic of organelles and other cargo particles in cells. In contrast to the macroscopic traffic of cars, however, the traffic of molecular motors is…

统计力学 · 物理学 2009-12-04 Stefan Klumpp , Melanie J. I. Müller , Reinhard Lipowsky

Intracellular transport along microtubules or actin filaments, powered by molecular motors such as kinesins, dyneins or myosins, has been recently modeled using one-dimensional driven lattice gases. We discuss some generalizations of these…

生物物理 · 物理学 2007-10-09 Paolo Pierobon

Molecular motors transport various cargos along cytoskeletal filaments, analogous to trucks on roads. In contrast to vehicles, however, molecular motors do not work alone but in small teams. We describe a simple model for the transport of a…

统计力学 · 物理学 2008-07-08 Melanie J. I. Müller , Janina Beeg , Rumiana Dimova , Stefan Klumpp , Reinhard Lipowsky

Many cell functions are accomplished thanks to intracellular transport mechanisms of macromolecules along filaments. Molecular motors such as dynein or kinesin are proteins playing a primary role in these processes. The behavior of such…

混沌动力学 · 物理学 2010-12-21 Donatello Materassi , Subhrajit Roychowdhury , Murti V. Salapaka

Processive molecular motors which drive the traffic of organelles in cells move in a directed way along cytoskeletal filaments. On large time scales, they perform motor walks, i.e., peculiar random walks which arise from the repeated…

统计力学 · 物理学 2007-05-23 Stefan Klumpp , Theo M. Nieuwenhuizen , Reinhard Lipowsky

Enzymatic molecules that actively support many cellular processes, including transport, cell division and cell motility, are known as motor proteins or molecular motors. Experimental studies indicate that they interact with each other and…

生物物理 · 物理学 2015-05-20 Daniel Celis-Garza , Hamid Teimouri , Anatoly B. Kolomeisky

Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which…

生物物理 · 物理学 2008-03-07 Debashish Chowdhury

Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials. We investigate the…

统计力学 · 物理学 2015-06-18 Hamid Teimouri , Anatoly B. Kolomeisky , Kareem Mehrabiani

Filament based intracellular transport involves the collective action of molecular motor proteins. Experimental evidences suggest that microtubule (MT) filament bound motor proteins such as {\it kinesins} weakly interact among themselves…

软凝聚态物质 · 物理学 2015-06-23 Sameep Chandel , Abhishek Chaudhuri , Sudipto Muhuri

Cytoskeletal motors known as motor proteins are molecules that drive cellular transport along several parallel cytoskeletal filaments and support many biological processes. Experimental evidences suggest that they interact with the nearest…

统计力学 · 物理学 2017-11-22 Tripti Midha , A. K. Gupta

Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells,…

生物物理 · 物理学 2009-11-11 Debashish Chowdhury , Andreas Schadschneider , Katsuhiro Nishinari

Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells,…

生物物理 · 物理学 2008-01-16 Debashish Chowdhury , Andreas Schadschneider , Katsuhiro Nishinari

Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large. The cytoskeleton,…

生物物理 · 物理学 2017-09-20 Cecile Appert-Rolland , Maximilian Ebbinghaus , Ludger Santen

We review the properties of biological motor proteins which move along linear filaments that are polar and periodic. The physics of the operation of such motors can be described by simple stochastic models which are coupled to a chemical…

生物物理 · 物理学 2009-10-31 Frank Julicher

Motivated by recent experimental results for the step sizes of dynein motor proteins, we develope a cellular automata model for intra-cellular traffic of dynein motors incorporating special features of the hindrance-dependent step size of…

统计力学 · 物理学 2009-11-11 Ambarish Kunwar , Andreas Schadschneider , Debashish Chowdhury

Routinely navigating through an ever-changing and unsteady environment, and utilizing chemical energy, molecular motors transport the cell's crucial components, such as neurotransmitters and organelles. They generate force and pull cargo,…

生物物理 · 物理学 2012-09-28 Bartosz Lisowski , Michał Żabicki

Movements of molecular motors on cytoskeletal filaments are described by directed walks on a line. Detachment from this line is allowed to occur with a small probability. Motion in the surrounding fluid is described by symmetric random…

统计力学 · 物理学 2007-05-23 Theo M. Nieuwenhuizen , Stefan Klumpp , Reinhard Lipowsky

One common feature of a vehicle, an ant and a kinesin motor is that they all convert chemical energy, derived from fuel or food, into mechanical energy required for their forward movement; such objects have been modelled in recent years as…

统计力学 · 物理学 2009-11-10 Debashish Chowdhury

In intracellular transports, motor proteins transport macromolecules as cargos to desired locations by moving on biopolymers such as microtubules. Recent experiments suggest that cargos that can associate motor proteins during their…

生物物理 · 物理学 2023-07-04 Sutapa Mukherji , Dhruvi K. Patel
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