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Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. Most microfluidic biochips are based on the principle of continuous fluid flow…

硬件体系结构 · 计算机科学 2011-11-09 Fei Su , Krishnendu Chakrabarty

At submicron manufacturing technology nodes process variations affect circuit performance significantly. This trend leads to a large timing margin and thus overdesign to maintain yield. To combat this pessimism, post-silicon clock tuning…

硬件体系结构 · 计算机科学 2017-05-16 Grace Li Zhang , Bing Li , Ulf Schlichtmann

Given the ever-increasing advances of digital microfluidic biochips and their application in a wide range of areas including bio-chemistry experiments, diagnostics, and monitoring purposes like air and water quality control and etc.,…

新兴技术 · 计算机科学 2020-01-01 Alireza Abdoli

Design of microfluidic biochips has led to newer challenges to the EDA community due to the availability of various flow-based architectures and the need for catering to diverse applications such as sample preparation, personalized…

新兴技术 · 计算机科学 2021-07-28 Tapalina Banerjee , Sudip Poddar , Tsung-Yi Ho , Bhargab B. Bhattacharya

This paper considers a developing theory on the effects of inevitable process variations during the fabrication of MEMS and other microsystems. The effects on the performance and design yield of the microsystems devices are analyzed and…

其他计算机科学 · 计算机科学 2007-11-29 S. -P. Vudathu , K. -K. Duganapalli , Rainer Laur , D. Kubalinska , A. Bunse-Gerstner

Flow-based microfluidic biochips have attracted much atten- tion in the EDA community due to their miniaturized size and execution efficiency. Previous research, however, still follows the traditional computing model with a dedicated…

新兴技术 · 计算机科学 2017-05-16 Chunfeng Liu , Bing Li , Hailong Yao , Paul Pop , Tsung-Yi Ho , Ulf Schlichtmann

The growing demand for compute-intensive applications has made multi-chiplet architectures a promising alternative to monolithic designs, offering improved scalability and manufacturing flexibility. However, effectively managing the…

硬件体系结构 · 计算机科学 2026-01-27 Zizhen Liu , Fangzhiyi Wang , Mengdi Wang , Jing Ye , Hayden Kwok-Hay So , Cheng Liu , Huawei Li

Microfluidic chips provide unparalleled control over droplets and jets, which have advanced all natural sciences. However, microfluidic applications could be vastly expanded by increasing the per-channel throughput and directly exploiting…

流体动力学 · 物理学 2020-02-06 Claas Willem Visser , Tom Kamperman , Lisanne P. Karbaat , Detlef Lohse , Marcel Karperien

Flow-based microfluidic biochips are widely used in lab- on-a-chip experiments. In these chips, devices such as mixers and detectors connected by micro-channels execute specific operations. Intermediate fluid samples are saved in storage…

新兴技术 · 计算机科学 2017-05-16 Tsun-Ming Tseng , Bing Li , Tsung-Yi Ho , Ulf Schlichtmann

Digital microfluidic (DMF) biochips are now being extensively used to automate several biochemical laboratory protocols such as clinical analysis, point-of-care diagnostics, and polymerase chain reaction (PCR). In many biological assays,…

Constraint-based optimization of microbial strains and model-based bioprocess design have been used extensively to enhance yields in biotechnological processes. However, strain and process optimization are usually carried out in sequential…

最优化与控制 · 数学 2024-07-31 Anita L. Ziegler , Ashutosh Manchanda , Marc-Daniel Stumm , Lars M. Blank , Alexander Mitsos

Microfluidic biochips are replacing the conventional biochemical analysers integrating the necessary functions on-chip. We are interested in Flow-Based Microfluidic Biochips (FBMB), where a continuous flow of liquid is manipulated using…

新兴技术 · 计算机科学 2025-05-07 Alexander Schneider , Jan Madsen , Paul Pop

A hierarchical approach to the construction of compound distributions for process-induced faults in IC manufacture is proposed. Within this framework, the negative binomial distribution and the compound binomial distribution are treated as…

数据分析、统计与概率 · 物理学 2007-05-23 Yu. I. Bogdanov , N. A. Bogdanova , V. L. Dshkhunyan

Growth rates and biomass yields are key descriptors used in microbiology studies to understand how microbial species respond to changes in the environment. Of these, biomass yield estimates are typically obtained using cell counts and…

定量方法 · 定量生物学 2022-05-02 Antonio R. Paiva , Giovanni Pilloni

Abstract: In our paper the new algorithm enhanced multi gradient Dilution Preparation (EMDP) is discussed. This new algorithm is reported with a lab on chip or digital Microfluidic biochip to operate multiple operation on a tiny chip. We…

新兴技术 · 计算机科学 2021-10-04 Meenakshi Sanyal , Somenath Chakraborty

Microfluidic droplet screens serve as an innovative platform for high-throughput biotechnology, enabling significant advancements in discovery, product optimization, and analysis. This review sheds light on the emerging trend of interaction…

定量方法 · 定量生物学 2023-09-11 Carolus Vitalis , Tobias Wenzel

The flexible operation of electrified chemical processes, powered by renewable electricity, offers economic and ecological incentives, paving the way for a more sustainable chemical industry. However, this requires a departure from the…

最优化与控制 · 数学 2023-08-21 Mohammad El Wajeh , Adel Mhamdi , Alexander Mitsos

Digital microfluidic biochips (DMFBs) are revolutionary biomedical devices towards diagnostics and point-of-care applications; the chips provide the capability of performing wide ranges of biochemistry and laboratory procedures, offering…

新兴技术 · 计算机科学 2020-09-01 Alireza Abdoli , Sedigheh Farhadtoosky , Ali Jahanian

Digital Microfluidic Biochips consist of Two Dimensional microarrays that are integrated with different healthcare related cyberphysical systems and expected to be used extensively in near future. Thus, faster and error-free synthesis…

新兴技术 · 计算机科学 2018-04-10 Sarit Chakraborty , Susanta Chakraborty

We present a new methodology for efficient and high-quality patterning of biological reagents for surface-based biological assays. The method relies on hydrodynamically confined nanoliter volumes of reagents to interact with the substrate…

生物大分子 · 定量生物学 2016-04-27 J. Autebert , J. F. Cors , David P. Taylor , G. V. Kaigala
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