定量生物学
Protein design has the potential to revolutionize biotechnology and medicine. While most efforts have focused on proteins with well-defined structures, increased recognition of the functional significance of intrinsically disordered…
Summary: Microbiome HiFi Amplicon Sequence Simulator (MHASS) creates realistic synthetic PacBio HiFi amplicon sequencing datasets for microbiome studies, by integrating genome-aware abundance modeling, realistic dual-barcoding strategies,…
Antiterminators are essential components of bacterial transcriptional regulation, allowing the control of gene expression in response to fluctuating environmental conditions. Among them, RNA-binding antiterminator proteins play a major role…
This paper investigates a behavioral-feedback SIR model in which the infection rate adapts dynamically based on the fractions of susceptible and infected individuals. We introduce an invariant of motion and we characterize the peak of…
Reproducibility of computational research is critical for ensuring transparency, reliability and reusability. Challenges with computational reproducibility have been documented in several fields, but healthcare discrete-event simulation…
We derive a charge conserving phase space cable equation for the propagating action potential, expressing ionic, capacitive and axoplasmic currents as functions of membrane potential. The new equation prediction of ionic current crossing…
The macroscopic (population-level) dynamics of chemotactic cell movement -- arising from underlying microscopic (individual-based) models -- are often described by parabolic partial differential equations (PDEs) governing the…
This study presents a mathematical model formulated as a system of first-order non-linear ordinary differential equations, aimed at examining the effects of different factors, classified as local and systemic factors on a wound healing…
Epidemic control frequently relies on adjusting interventions based on prevalence. But designing such policies is a highly non-trivial problem due to uncertain intervention effects, costs and the difficulty of quantifying key transmission…
Background: Outdoor navigation poses significant challenges for people with blindness or low vision, yet the role of gaze behavior in supporting mobility remains underexplored. Fully sighted individuals typically adopt consistent scanning…
PF708 teriparatide, manufactured by Alvogen, was approved through the 505(B)(2) application after the expiration of Forteo market exclusivity in October 2019. The 505(B)(2) application allows safety and efficacy information to come from…
Moving animal groups consist of many distinct individuals but can operate and function as one unit when performing different tasks. Effectively evading unexpected predator attacks is one primary task for many moving groups. The current…
Tumor-immune interactions are shaped by both antigenic heterogeneity and stochastic perturbations in the tumor microenvironment, yet the mathematical mechanisms underlying immune phase transitions remain poorly understood. We propose a…
Complex patterns emerge across a wide range of biological systems. While such patterns often exhibit remarkable robustness, variation and irregularity exist at multiple scales and can carry important information about the underlying agent…
Consciousness spans macroscopic experience and microscopic neuronal activity, yet linking these scales remains challenging. Prevailing theories, such as Integrated Information Theory, focus on a single scale, overlooking how causal power…
Human social life is shaped by repeated interactions, where past experiences guide future behavior. In evolutionary game theory, a key challenge is to identify strategies that harness such memory to succeed in repeated encounters. Decades…
Dengue, a mosquito-borne viral disease common in tropical areas, is spread by Aedes aegypti and Aedes albopictus. Temperature changes driven by climate affect vector ecology and expand regions of species coexistence. The combined effect of…
The gene set analysis (GSA) is a foundational approach for uncovering the molecular functions associated with a group of genes. Recently, LLM-powered methods have emerged to annotate gene sets with biological functions together with…
Video-based assessment of motor symptoms in conditions such as Parkinson's disease (PD) offers a scalable alternative to in-clinic evaluations, but home-recorded videos introduce significant challenges, including visual degradation,…
As a lightweight and non-invasive imaging technique, lung ultrasound (LUS) has gained importance for assessing lung pathologies. The use of Artificial intelligence (AI) in medical decision support systems is promising due to the time- and…