组织与器官
In this study, a computational simulation is employed to place two essential parameters, the permeability of vessels and hydraulic conductivity, under assessment. These parameters impact the movement of drug particles through vessels, and…
UV-cured collagen-based hydrogels hold promise in skeletal muscle regeneration due to their soft elastic properties and porous architecture. However, the complex triple helix conformation of collagen and environmental conditions, i.e.…
Arterial deformations arise in blood flow when surrounding tissue invades the space available for a blood vessel to maintain its circular cross section, the most immediate effects being a reduction in blood flow and redistribution of shear…
The interactions between cells and the extracellular matrix are vital for the self-organisation of tissues. In this paper we present proof-of-concept to use machine learning tools to predict the role of this mechanobiology in the…
Atherosclerotic lesions within carotid and cerebral vessels are likely to influence hemodynamics and manifest into vascular pathologies, including Alzheimers Disease and ischemic stroke. Hemodynamics are influenced by changes in luminal…
A computational anatomy atlas is a set of internal organ geometries. It is based on data of real patients and complemented with virtual cases by using a some numerical approach. Atlases are in demand in computational physiology, especially…
We are keenly interested in finding the limiting behaviors of total tumor size when tumor cells are subject to the periodic repetition of therapy and rest periods, called intermittent cyclic therapy. We hypothesize that each tumor cell can…
The growth of many solid tumors has been found to be driven by chemo- and radiotherapy-resistant cancer stem cells (CSCs). A suitable therapeutic avenue in these cases may involve the use of a differentiating agent (DA) to force the…
Purpose: Critical torque (CT) and work done above it (W') are key predictors of exercise performance associated with neuromuscular fatigue. The aim of the present study was to understand the role of the metabolic cost of exercise in…
Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…
Effects of mechanical stress on the permeability of vascular endothelium are important to normal physiology and may be critical in the development of atherosclerosis, where they can account for the patchy arterial distribution of the…
Objectives: This article sheds light on the different heat stress management strategies, common or innovative, in order to analyze those that would be the most suitable and effective for athletes who have to compete in humid and/or hot…
Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific…
Continuous wound monitoring is one strategy to minimise infection severity and inform prompt variations in therapeutic care following infection diagnosis. However, integration of this functionality in therapeutic wound dressings is still…
During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the…
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and…
A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. We constructed a multiscale mathematical model of the process with three components:…
We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al. 2012 for the spread of a lesion formed though a single…
The increasing availability of wearable electrocardiography (ECG) devices enables the continuous monitoring of individual ECG alterations. This could be beneficial for patients suffering from acute ischemia but with non-standard ECG…
Scroll wave chaos is thought to underlie life-threatening ventricular fibrillation. However, currently there is no direct way to measure action potential wave patterns transmurally throughout the thick ventricular heart muscle.…