定量方法
Due to delay in reporting, the daily national and statewide COVID-19 incidence counts are often unreliable and need to be estimated from recent data. This process is known in economics as nowcasting. We describe in this paper a simple…
Abortion is one of the biggest causes of maternal deaths, accounting for 15% of maternal deaths in Southeast Asia. The increase in and effectiveness of using contraception are still considered to be the effective method to reduce abortion…
Tuberculosis remains today a major public health issue with a total of 9 million new cases and 2 million deaths annually. The lack of an effective vaccine and the increasing emergence of new strains of Mycobacterium tuberculosis (Mtb)…
Advances in imagery at atomic and near-atomic resolution, such as cryogenic electron microscopy (cryo-EM), have led to an influx of high resolution images of proteins and other macromolecular structures to data banks worldwide. Producing a…
More and more diseases have been found to be strongly correlated with disturbances in the microbiome constitution, e.g., obesity, diabetes, or some cancer types. Thanks to modern high-throughput omics technologies, it becomes possible to…
Infrared thermography (IRT) is a valuable diagnostic tool in equine veterinary medicine however, little is known about its application in donkeys. The aim was to find patterns in thermal images of donkeys and horses, and determine if these…
Presence-only data are a typical occurrence in species distribution modeling. They include the presence locations and no information on the absence. Their modeling usually does not account for detection biases. In this work, we aim to merge…
Network inference is a major field of interest for the ecological community, especially in light of the high cost and difficulty of manual observation, and easy availability of remote, long term monitoring data. In addition, comparing…
Background: Software is an important windows to offer a variety of complex instrument control and data processing for nuclear magnetic resonance (NMR) spectrometer. NMR software should allow researchers to flexibly implement various…
In this manuscript we analyze a data set containing information on children with Hodgkin Lymphoma (HL) enrolled on a clinical trial. Treatments received and survival status were collected together with other covariates such as demographics…
Previously we have developed the concept of the dynamic pathosome, which suggests that individual patterns of phenotype development, i.e., phenotypic trajectories, contain more information than is commonly appreciated and that a phenotype's…
Bone regeneration is a clinical challenge that requires multiple approaches. Sometimes, it also includes the development of new osteogenic and antibacterial biomaterials to treat the occurrence of possible infection processes derived from…
Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several dose-finding studies are conducted, although often with some variation in the administration mode or dose panel. For instance,…
Mesoporous bioactive glasses, MBG, are gaining increasing interest in the design of new biomaterials for bone defects treatment. An important research trend to enhance their biological behavior is the inclusion of moderate amounts of oxides…
B-cell epitopes play a key role in stimulating B-cells, triggering the primary immune response which results in antibody production as well as the establishment of long-term immunity in the form of memory cells. Consequently, being able to…
Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear. Here, we identify a…
Sleep disorders can be a negative factor both for learning as for the mental and physical development of adolescents. It has been shown that, in many populations, adolescents tend to have a poor sleep quality, and a very late chronotype.…
Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we…
Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…
Automatic analysis of bioacoustic signals is a fundamental tool to evaluate the vitality of our planet. Frogs and bees, for instance, may act like biological sensors providing information about environmental changes. This task is…