定量方法
Introduction: Quantitative Susceptibility Mapping (QSM) is generally acquired with full brain coverage, even though many QSM brain-iron studies focus on the deep grey matter (DGM) region only. Reducing the spatial coverage to the DGM…
Population-scale drug prescription data linked with adverse drug reaction (ADR) data supports the fitting of models large enough to detect drug use and ADR patterns that are not detectable using traditional methods on smaller datasets.…
The application of microscopy in biomedical research has come a long way since Antonie van Leeuwenhoek discovered unicellular organisms. Countless innovations have positioned light microscopy as a cornerstone of modern biology and a method…
The complex-pole frequency representation (COFRE) is introduced in this paper as a new approach for spectrum modeling in biomedical signals. Our method allows us to estimate the spectral power density at precise frequencies using an array…
Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…
Nature, a synthetic master, creates more than 300,000 natural products (NPs) which are the major constituents of FDA-proved drugs owing to the vast chemical space of NPs. To date, there are fewer than 30,000 validated NPs compounds involved…
Protein engineering seeks to identify protein sequences with optimized properties. When guided by machine learning, protein sequence generation methods can draw on prior knowledge and experimental efforts to improve this process. In this…
The mainstay of canine rabies control is fixed point mass dog vaccination campaigns (MDVC). However, in some regions, ideal vaccination coverage in dogs is not obtained due to low participation in the MDVC. Travel distance to the…
Ordinary differential equation models are nowadays widely used for the mechanistic description of biological processes and their temporal evolution. These models typically have many unknown and non-measurable parameters, which have to be…
Our atmosphere is constantly changing and new pathogens are erupting now and then and the existing pathogens are mutating continuously. Some of these pathogens, such as SARS-CoV-2, become so deadly that they put the whole technological…
Despite substantial potential to transform bioscience, medicine, and bioengineering, whole-cell models remain elusive. One of the biggest challenges to whole-cell models is assembling the large and diverse array of data needed to model an…
Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of biomolecules at near-atomic resolution. As such, it represents one of the most promising imaging techniques in structural biology. However, raw cryo-EM…
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method for the solution of…
Leaf Area index is widely used metric for the assessment of vegetation dynamics and can be used to assess the impact of regional/local climate conditions. The underlying continuity of high resolution spatio-temporal phenological processes…
We develop a spatially dependent generalisation to the Wells-Riley model and its extensions applied to COVID-19, that determines the infection risk due to airborne transmission of viruses. We assume that the concentration of infectious…
Fish swim by undulating their bodies. These propulsive motions require coordinated shape changes of a body that interacts with its fluid environment, but the specific shape coordination that leads to robust turning and swimming motions…
Chimeric antigen receptor T cell therapy has demonstrated innovative therapeutic effectiveness in fighting cancers; however, it is extremely expensive due to the intrinsic patient-to-patient variability in cell manufacturing. We propose in…
This paper applies statistical learning techniques to an observational Quantified-Self (QS) study to build a descriptive model of sleep quality. A total of 472 days of my sleep data was collected with an Oura ring and combined with…
In this study, we develop a methodology for model reduction and selection informed by global sensitivity analysis (GSA) methods. We apply these techniques to a control model that takes systolic blood pressure and thoracic tissue pressure…
Although Zika virus (ZIKV) seems to be prominently neurotropic, there are some reports of involvement of other organs, particularly the heart. Of special concern are those children exposed prenatally to ZIKV and born with no microcephaly or…