定量方法
Like many scientific fields, new chemistry literature has grown at a staggering pace, with thousands of papers released every month. A large portion of chemistry literature focuses on new molecules and reactions between molecules. Most…
Microdialysis is a well-established method for in vivo neurochemical measurements of small molecules, with implanted concentric-design probes offering minimized tissue damage and good temporal and spatial resolution. However, the large…
Discrete dynamical systems in which model components take on categorical values have been successfully applied to biological networks to study their global dynamic behavior. Boolean models in particular have been used extensively. However,…
In this study, we propose the convolutional recurrent neural network and transfer learning (CRNNTL) for QSAR modelling. The method was inspired by the applications of polyphonic sound detection and electrocardiogram classification. Our…
Prediction of Overall Survival (OS) of brain cancer patients from multi-modal MRI is a challenging field of research. Most of the existing literature on survival prediction is based on Radiomic features, which does not consider either…
Radiomics is an active area of research focusing on high throughput feature extraction from medical images with a wide array of applications in clinical practice, such as clinical decision support in oncology. However, noise in low dose…
This article compares ten recently proposed neural networks and proposes two ensemble neural network-based models for blood glucose prediction. All of them are tested under the same dataset, preprocessing workflow, and tools using the…
Despite popular media interest in uncovering the creative habits of successful people, there is a surprising paucity of empirical research on the diversity of tendencies and preferences people have when engaged in creative work. We…
Many cephalopods such as octopus and squid change their skin color purposefully within a very short time. Furthermore, it is widely known that some octopuses have the ability to change the color and unevenness of the skin and to mimic the…
The study and applications of ferroelectric materials in the biomedical and biotechnological fields is a novel and very promising scientific area that spans roughly one decade. However, some groups have already provided experimental proof…
For several decades optical tweezers have proven to be an invaluable tool in the study and analysis of a myriad biological responses and applications. However, as every tool, it can have undesirable or damaging effects upon the very sample…
Irregularly sampled time series data are common in a variety of fields. Many typical methods for drawing insight from data fail in this case. Here we attempt to generalize methods for clustering trajectories to irregularly and sparsely…
To combat the recent coronavirus disease 2019 (COVID-19), academician and clinician are in search of new approaches to predict the COVID-19 outbreak dynamic trends that may slow down or stop the pandemic. Epidemiological models like…
Estimating animal abundance and density are fundamental goals of many wildlife monitoring programs. Camera trapping has become an increasingly popular tool to achieve these monitoring goals due to recent advances in modeling approaches and…
Understanding primate behavior is a mission-critical goal of both biology and biomedicine. Despite the importance of behavior, our ability to rigorously quantify it has heretofore been limited to low-information measures like preference,…
We propose a novel approach to generate samples from the conditional distribution of patient-specific cardiovascular models given a clinically aquired image volume. A convolutional neural network architecture with dropout layers is first…
Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…
Background: Trypanosoma brucei is the causative agent of human African sleeping sickness and Nagana in cattle. In addition to being an important pathogen T. brucei has developed into a model system in cell biology. Results: Using Stable…
Correlative imaging workflows are now widely used in bioimaging and aims to image the same sample using at least two different and complementary imaging modalities. Part of the workflow relies on finding the transformation linking a source…
Cellular composition prediction, i.e., predicting the presence and counts of different types of cells in the tumor microenvironment from a digitized image of a Hematoxylin and Eosin (H&E) stained tissue section can be used for various tasks…