其他定量生物学
Achieving complete reproducibility in science, particularly in research fields such as biodiversity, is challenging due to analytical choices, bias and interpretation. Here, we examine examples of reproducibility in biological systematics,…
As humanity prepares for sustained off-world habitation, the development of regolith-based agriculture (RBA) is essential for achieving self-sufficiency in space crop production. However, lunar regolith's alkaline pH, poor water retention,…
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These…
Benchmarking, which involves collecting reference datasets and demonstrating method performances, is a requirement for the development of new computational tools, but also becomes a domain of its own to achieve neutral comparisons of…
This study was carried out to estimate the effect of organic fertilizer and Nano Calcium spray on the growth, yield, and storage of fig fruits cv. Waziri. It was conducted in the village of Kani Sard in the Sharbazhir district near the…
In this study, we used a dataset of approximately 96,000 reported dengue cases from 2015 to 2024 in Recife, the capital of northeastern Brazil, all geocoded by neighborhood. The dataset was enriched with sociodemographic data from the…
This perspective posits that gene-environment interplay (GxE) studies should be developed both theoretically and empirically to be of relevance to policy makers. On the theoretical front, this development is essential because the current…
Traditional Chinese Medicine diagnosis and treatment principles, established through centuries of trial-and-error clinical practice, directly maps patient-specific symptom patterns to personalised herbal therapies. These empirical holistic…
Amateur marathon runners who exercise excessively over time have pathological structural changes in their hearts and aortas. Amateur marathon runners' cardiovascular system adaptations and dangers are discussed in this article. After…
Adaptive therapy improves cancer treatment by controlling the competition between sensitive and resistant cells through treatment holidays. This study highlights the critical role of treatment-holiday thresholds in adaptive therapy for…
Artificial intelligence (AI) is increasingly being explored as a tool to support pharmacometric modeling, particularly in addressing the coding challenges associated with NONMEM. In this study, we evaluated the ability of seven AI agents to…
Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the internal representations of large language models (LLMs), revealing latent latent features with semantical meaning. This interpretability has also…
Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and…
Standards play a crucial role in ensuring consistency, interoperability, and efficiency of communication across various disciplines. In the field of synthetic biology, the Synthetic Biology Open Language (SBOL) Visual standard was…
The present study aimed to investigate the genetic diversity in 42 German chamomile populations using morphological, biochemical, and ssr molecular markers, in both field and laboratory sections. Different populations of German chamomile…
Fieldwork is an essential component not just for organismal biology but also for the expanding umbrella of disciplines that have turned their attention toward the physics of living systems. Observing organisms in nature is a critical…
Petri Nets are an increasingly used modeling framework for the spread of disease across populations or within an individual. For example, the Susceptible-Infectious-Recovered (SIR) compartment model is foundational for population…
This study presents a rigorous assessment of the growth performance of Gmelina arborea (melina) in a 67-hectare plantation located in Chontaduro, Tabiazo Parish, Esmeraldas, Ecuador. The plantation was established in 2017 under a…
First discovered by L. R. Taylor (1961, Nature), Taylor's Power Law (TPL) correlates the mean (M) population abundances and the corresponding variances (V) across a set of insect populations using a power function (V=aM^b). TPL has…
Merely by existing, all physical systems contain information, and physical dynamics transforms and processes that information. This note investigates the information processing power of living systems. Living systems harvest free energy…