生物物理
The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaffolds were fabricated by a foam replica…
Bioceramic porous microspheres are promising substances for dental and orthopedic bone void filling, tissue engineering and drug delivery applications. In this research, the structure and cytocompatibility of bioactive magnesium-calcium…
We investigate connectivity properties of the SARS-CoV2 spike protein-human ACE2-receptor complex employing a protein side chain-based network method that allows us to span a range from atomic to global protein scales. We analyze network…
This paper is devoted to studies of the mechanical deformation of the S. aureus cell wall. The bacterium is modelled as a thin elastic membrane containing cytoplasm, which is treated as an incompressible fluid. Deformation occurs via Van…
Recent advances in the field of active soft matter promise a lot. Both, experimental advances and theoretical understanding point towards new material classes in reach, for example self-healing materials that might switch their properties…
Dynamic soaring allows seabirds to harvest mechanical energy from vertical wind shear, but field trajectories lack a benchmark for comparing flight performances across species. We derive a reduced lower bound on transport effort from a…
Many complex systems, ranging from migrating cells to animal groups, exhibit stochastic dynamics described by the underdamped Langevin equation. Inferring such an equation of motion from experimental data can provide profound insight into…
Membrane wrapping underlies nanoparticle uptake during endocytosis, whereas the reverse process of membrane unwrapping accompanies particle expulsion and membrane fusion events. Existing theoretical descriptions typically focus on adhesion…
We learn parameterized nonlinear elasticity on curved surfaces using a physics-informed neural network that enforces governing equations and boundary conditions directly through the loss function, enabling a single trained model to…
We study here the collective quantum optical effect of superradiance in neuroprotein architectures. This phenomenon arises from the interaction of the electromagnetic field with an organized network of tryptophan chromophores, where each…
Dynamic functional connectivity (dFC) is ubiquitously observed in the brain, but why functional networks should remain dynamic even at rest is unclear. We asked whether temporal reconfiguration becomes advantageous when keeping a functional…
The ubiquitous $3/4$ metabolic scaling exponent, known as Kleiber's law, has long been attributed to the minimization of viscous dissipation within fractal transport networks. In this paper, we invert this standard narrative, demonstrating…
Biological tissues are active materials whose non-equilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of traction forces and junctional tension…
Planktonic organisms such as copepods sense swimming prey and sinking food particles through the hydrodynamic disturbances they generate. However, because these flow fields are often highly symmetric, they provide little directional…
Fluorescence microscopy is essential in biological and medical research, providing critical insights into cellular structures. However, limited by optical diffraction and background noise, a substantial amount of hidden information is still…
Fluorescent nanothermometry has revealed pronounced intracellular temperature heterogeneity, establishing the field of single-cell thermal biology. However, these observations have sparked a controversy known as the "10^5 gap issue",…
Physics perfectly describes neuronal operation, provided that we take into account that biology uses slow, positively charged ions rather than electrons as charge carriers and remove untested ad hoc hypotheses that contradict science's…
Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…
Background Double Kissing (DK) Crush is a two-stent technique for complex coronary bifurcation lesions, yet the biomechanical influence of plaque on its performance remains poorly understood. This study developed a computational…
Immotile microbes inhabit nearly every environment on Earth, from soils and sediments to food matrices -- yet how they disperse through these physically confining environments is poorly understood. Here, we show that immotile microbial…