生物物理
We observe that the time averaged continuous Price equation is identical to the positive momentum virial theorem, and we discuss the applications and implications of this connection.
Intrinsically disordered proteins and regions are increasingly appreciated for their abundance in the proteome and the many functional roles they play in the cell. In this short review, we describe a variety of approaches used to obtain…
Membrane proteins often need to be inserted into or attached on the cell membrane to perform their functions. Understanding their transmembrane topology and conformational dynamics during insertion is crucial for elucidating their roles.…
Single-molecule surface-induced fluorescence attenuation (smSIFA) is a precise method for studying the vertical movement of biological macromolecules using two-dimensional material acceptors. Unlike other methods, smSIFA is not influenced…
As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activity emerges from networks of fine-scale correlations. While modeling these populations is…
This paper attempts to review our studies on the propagation of signals in nerves over the past decade. The need for interdisciplinary studies is stressed that helps to understand the physical mechanisms of coupling the electrical,…
Ultra-high dose-rate (UHDR) radiotherapy, characterized by an extremely high radiation delivery rate, represents one of the most recent and promising frontier in radiotherapy. UHDR radiotherapy, addressed in the field as FLASH radiotherapy,…
Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation. Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific…
Shape transformations of epithelial tissues in three dimensions, which are crucial for embryonic development or in vitro organoid growth, can result from active forces generated within the cytoskeleton of the epithelial cells. How the…
The origins of life is a question that continues to intrigue scientists across disciplines. One theory - the iron-sulphur theory - suggests that reactions essential to the synthesis of biological materials got their catalytic 'spark' from…
Renewable and biodegradable plastics derived from soy protein isolate (SPI) offer a promising alternative to conventional petroleum-based plastics, particularly for film-grade bioplastics applications such as plastic bags. However, even…
Epithelial tissues are continuously exposed to cyclic stretch. Physiological stretching has been found to regulate soft tissue function at the molecular, cellular, and tissue scales, allowing tissues to preserve their homeostasis and adapt…
Endpoint dilution (TCID50) assays cannot count the number of infectious virions (IVs), and instead are limited to counting the number of Specific INfections caused by the sample (SIN). The latter depends not only on whether virions are…
In the present paper we address the general problem of selective electrodynamic interactions between DNA and protein, which is motivated by decades of theoretical study and our very recent experimental findings (M. Lechelon et al,…
Spatial patterns are widely observed in numerous nonequilibrium natural systems, often undergoing complex transitions and bifurcations, thereby exhibiting significant importance in many physical and biological systems such as embryonic…
During wound healing, fish keratocyte cells undergo galvanotaxis where they follow a wound-induced electric field. In addition to their stereotypical persistent motion, keratocytes can develop circular motion without a field or oscillate…
The migration behavior of colliding cells is critically determined by transient contact-interactions. During these interactions, the motility machinery, including the front-rear polarization of the cell, dynamically responds to surface…
The complexity of gene regulatory networks in multicellular organisms makes interpretable low-dimensional models highly desirable. An attractive geometric picture, attributed to Waddington, visualizes the differentiation of a cell into…
To elucidate the mechanism by which THz radiation non-thermally affects living organisms, the lateral diffusion constants of lipid molecules in the cell membranes of HeLa cells were measured using fluorescence recovery after photobleaching…
The use of exogenous pulmonary surfactant (EPS) to deliver other relevant drugs to the lung is a promising strategy for combined therapy. We evaluated the interaction of polymyxin B (PxB) with clinically used EPS, the poractant alfa…