有限浓度下红细胞聚集物的输送
摘要
红细胞(RBC)负责将氧气和各种代谢物输送至组织和器官，同时负责排除废物。Several cardiovascular diseases can impair these functions. For instance, in diabetes, increased RBC aggregation can lead to blood occlusion, thereby depriving tissues of efficient oxygen delivery. Interestingly, RBC adhesion occurs not only in disease states but also under physiological conditions, with the key difference being that adhesion is reversible in healthy situations. This paper focuses on numerical simulations in 2D, exploring different adhesion energies (both physiological and pathological) alongside varying flow strengths and hematocrit levels. A systematic analysis of RBC flux and viscosity is conducted. A remarkable finding is that moderate adhesion energy (within the physiological range) enhances RBC transport, thereby improving oxygen delivery to tissues. This provides insight into why RBC adhesion is present under normal conditions. Conversely, increasing adhesion energy beyond a certain point causes a collapse in RBC flux, thus reducing oxygen transport. We provide a basic explanation for the non-monotonic effect of adhesion energy on blood flow efficiency. This finding serves as an initial step in understanding the impact (both positive and negative) of RBC adhesion before addressing this issue in complex networks inspired by realistic microvasculatures.
引用
@article{arxiv.2501.03860,
title = {Red blood cells aggregates transport for finite concentration},
author = {Mehdi Abbasi and Chaouqi Misbah},
journal= {arXiv preprint arXiv:2501.03860},
year = {2025}
}