Localization of Denaturation Bubbles in Random DNA Sequences
Statistical Mechanics
2016-08-31 v1 Disordered Systems and Neural Networks
Soft Condensed Matter
Biological Physics
Quantitative Methods
Abstract
We study the thermodynamic and dynamic behaviors of twist-induced denaturation bubbles in a long, stretched random sequence of DNA. The small bubbles associated with weak twist are delocalized. Above a threshold torque, the bubbles of several tens of bases or larger become preferentially localized to \AT-rich segments. In the localized regime, the bubbles exhibit ``aging'' and move around sub-diffusively with continuously varying dynamic exponents. These properties are derived using results of large-deviation theory together with scaling arguments, and are verified by Monte-Carlo simulations.
Cite
@article{arxiv.cond-mat/0302603,
title = {Localization of Denaturation Bubbles in Random DNA Sequences},
author = {Terence Hwa and Enzo Marinari and Kim Sneppen and Lei-han Tang},
journal= {arXiv preprint arXiv:cond-mat/0302603},
year = {2016}
}
Comments
TeX file with postscript figures