Lengthscales and Cooperativity in DNA Bubble Formation
Soft Condensed Matter
2007-05-23 v1 Biological Physics
Biomolecules
Abstract
It appears that thermally activated DNA bubbles of different sizes play central roles in important genetic processes. Here we show that the probability for the formation of such bubbles is regulated by the number of soft AT pairs in specific regions with lengths which at physiological temperatures are of the order of (but not equal to) the size of the bubble. The analysis is based on the Peyrard- Bishop-Dauxois model, whose equilibrium statistical properties have been accurately calculated here with a transfer integral approach.
Keywords
Cite
@article{arxiv.cond-mat/0511128,
title = {Lengthscales and Cooperativity in DNA Bubble Formation},
author = {Z. Rapti and A. Smerzi and K. Ø. Rasmussen and A. R. Bishop},
journal= {arXiv preprint arXiv:cond-mat/0511128},
year = {2007}
}